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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
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PathwaysReactions grouped under one name
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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

4,651–4,700 of 18,558 reactions from Rhea

a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2
Left to rightBalance undeterminableRhea 30299
(+)-(R)-germacrene A + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = germacra-1(10),4,11(13)-trien-12-oate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
Direction not assertedBalance undeterminableRhea 30303
7-methylxanthine + NADPH + O2 + H(+) = xanthine + formaldehyde + NADP(+) + H2O
Direction not assertedBalancedRhea 30307
7-methylxanthine + NADH + O2 + H(+) = xanthine + formaldehyde + NAD(+) + H2O
Direction not assertedBalancedRhea 30311
1,7-dimethylxanthine + NADH + O2 + H(+) = 7-methylxanthine + formaldehyde + NAD(+) + H2O
Direction not assertedBalancedRhea 30315
theobromine + NADH + O2 + H(+) = 7-methylxanthine + formaldehyde + NAD(+) + H2O
Direction not assertedBalancedRhea

30319

all-trans-beta-carotene + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = beta-cryptoxanthin + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 30323

beta-cryptoxanthin + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = all-trans-zeaxanthin + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 30327

all-trans-beta-carotene + 4 reduced [2Fe-2S]-[ferredoxin] + 2 O2 + 4 H(+) = all-trans-zeaxanthin + 4 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 30331

CTP + H2O + H(+) = UTP + NH4(+)

Left to rightBalancedRhea 30335

L-tryptophan + H(+) = tryptamine + CO2

Direction not assertedBalancedRhea 30339

FAD + succinate + H(+) = fumarate + FADH2

Direction not assertedBalancedRhea 30343

IDP + ATP = ITP + ADP

Left to rightBalancedRhea 30347

pyrrole-2-carboxylate + NADH + O2 + H(+) = 5-hydroxypyrrole-2-carboxylate + NAD(+) + H2O

Direction not assertedBalancedRhea 30351

methane + a quinol + O2 = methanol + a quinone + H2O

Direction not assertedBalance undeterminableRhea 30355

chlorophyllide a + 2 NADPH + 2 O2 + 2 H(+) = chlorophyllide b + 2 NADP(+) + 3 H2O

Direction not assertedBalancedRhea 30359

fumonisin B1 + 2 H2O = (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 tricarballylate + 2 H(+)

Direction not assertedBalancedRhea 30363

adenosylcob(III)alamin 5'-phosphate + H2O = adenosylcob(III)alamin + phosphate

Direction not assertedBalancedRhea 30367

(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone

Direction not assertedBalancedRhea 30371

(2E,6E)-farnesyl diphosphate = (+)-thujopsene + diphosphate

Direction not assertedBalancedRhea 30375

(2E,6E)-farnesyl diphosphate = (+)-beta-chamigrene + diphosphate

Direction not assertedBalancedRhea 30379

(2E,6E)-farnesyl diphosphate = (-)-7-epi-alpha-selinene + diphosphate

Direction not assertedBalancedRhea 30383

GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)

Direction not assertedBalancedRhea 30387

4-methylsulfanyl-2-oxobutanoate + L-glutamine = 2-oxoglutaramate + L-methionine

Direction not assertedBalancedRhea 30391

alpha-carotene + reduced [NADPH--hemoprotein reductase] + O2 = alpha-cryptoxanthin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 30399

Fe(3+)(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + Fe(2+)(out) + H(+)

Left to rightBalancedRhea 30403

reduced [plastocyanin] + hnu + oxidized [2Fe-2S]-[ferredoxin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]

Direction not assertedBalance undeterminableRhea 30407

benzyl alcohol + benzoyl-CoA = benzyl benzoate + CoA

Direction not assertedBalancedRhea 30411

octadecanal + 2 NADPH + O2 + H(+) = heptadecane + formate + 2 NADP(+) + H2O

Direction not assertedBalancedRhea 30415

(2E,6E)-farnesyl diphosphate = (+)-delta-selinene + diphosphate

Direction not assertedBalancedRhea 30423

(2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate

Direction not assertedBalancedRhea 30427

(S)-2,3-epoxysqualene = taraxerol

Direction not assertedBalancedRhea 30431

beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + tRNA(Gly) + H(+)

Direction not assertedBalancedRhea 30435

beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) = MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) + 2 H(+)

Direction not assertedBalancedRhea 30439

MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 glycyl-tRNA(Gly) = MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) + 2 H(+)

Direction not assertedBalancedRhea 30443

3-methylxanthine + NADH + O2 + H(+) = xanthine + formaldehyde + NAD(+) + H2O

Direction not assertedBalancedRhea 30447

(S)-2,3-epoxysqualene = isomultiflorenol

Direction not assertedBalancedRhea 30451

(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O = (-)-geosmin

Direction not assertedBalancedRhea 30455

(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol = (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone

Direction not assertedBalancedRhea 30459

(2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate

Direction not assertedBalancedRhea 30463

(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphate

Direction not assertedBalancedRhea 30467

(2Z,6Z)-farnesyl diphosphate = (1S,5S,6S)-alpha-bergamotene + diphosphate

Direction not assertedBalancedRhea 30471

oroxylin A 7-O-beta-D-glucuronate + H2O = oroxylin A + D-glucuronate + H(+)

Direction not assertedBalancedRhea 30475

L-isoleucine + reduced [NADPH--hemoprotein reductase] + O2 = N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 30479

N-hydroxy-L-isoleucine + reduced [NADPH--hemoprotein reductase] + O2 = N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 30483

N,N-dihydroxy-L-isoleucine + H(+) = (1E,2S)-2-methylbutanal oxime + CO2 + H2O

Direction not assertedBalancedRhea 30487

L-valine + reduced [NADPH--hemoprotein reductase] + O2 = N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 30491

N-hydroxy-L-valine + reduced [NADPH--hemoprotein reductase] + O2 = N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 30495

N,N-dihydroxy-L-valine + H(+) = (E)-2-methylpropanal oxime + CO2 + H2O

Direction not assertedBalancedRhea 30499

N-acetyl-L-glutamate 5-semialdehyde + H2O = L-glutamate 5-semialdehyde + acetate

Direction not assertedBalancedRhea 30503

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