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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

4,601–4,650 of 18,558 reactions from Rhea

(S)-2-hydroxyglutarate + FAD + H(+) = FADH2 + 2-oxoglutarate
Direction not assertedBalancedRhea 30087
a ubiquinone + D-alanine + H2O = a ubiquinol + pyruvate + NH4(+)
Direction not assertedBalance undeterminableRhea 30091
a menaquinone + (S)-malate = a menaquinol + oxaloacetate
Direction not assertedBalance undeterminableRhea 30095
all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate
Direction not assertedBalancedRhea 30099
2,5-didehydro-D-gluconate + NADH + H(+) = 5-dehydro-D-gluconate + NAD(+)
Direction not assertedBalancedRhea 30103
D-serine + NADP(+) = 2-aminomalonate semialdehyde + NADPH + H(+)
Direction not assertedBalancedRhea 30107
Fe(III)-enterobactin + 3 H2O + H(+) = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine

Direction not assertedBalancedRhea 30111

decanoyl-[ACP] + H2O = decanoate + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 30115

dodecanoyl-[ACP] + H2O = dodecanoate + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 30119

tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H(+)

Left to rightBalance undeterminableRhea 30123

octanoyl-[ACP] + H2O = octanoate + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 30131

dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)

Left to rightBalancedRhea 30135

octadecanoyl-CoA + H2O = octadecanoate + CoA + H(+)

Left to rightBalancedRhea 30139

octanoyl-CoA + H2O = octanoate + CoA + H(+)

Left to rightBalancedRhea 30143

FADH2 + NAD(+) = FAD + NADH + 2 H(+)

Direction not assertedBalancedRhea 30147

FADH2 + NADP(+) = FAD + NADPH + 2 H(+)

Direction not assertedBalancedRhea 30151

2 Fe(3+) + FADH2 = 2 Fe(2+) + FAD + 3 H(+)

Direction not assertedBalancedRhea 30155

D-erythrose 4-phosphate + dihydroxyacetone phosphate = D-sedoheptulose 1,7-bisphosphate

Direction not assertedBalancedRhea 30167

hexadecanoyl-[ACP] + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]

Direction not assertedBalance undeterminableRhea 30171

2 plastoquinone-9 + 15-cis-phytoene = 2 plastoquinol-9 + 9,9',15-tri-cis-zeta-carotene

Direction not assertedBalancedRhea 30175

oxidized 2[4Fe-4S]-[ferredoxin] + oxalate = reduced 2[4Fe-4S]-[ferredoxin] + 2 CO2

Direction not assertedBalance undeterminableRhea 30179

L-galactonate + NAD(+) = keto-D-tagaturonate + NADH + H(+)

Direction not assertedBalancedRhea 30183

(S)-dihydroorotate + a quinone = orotate + a quinol

Direction not assertedBalance undeterminableRhea 30187

plastoquinone-9 + 15-cis-phytoene = 15,9'-di-cis-phytofluene + plastoquinol-9

Direction not assertedBalancedRhea 30191

plastoquinone-9 + 15,9'-di-cis-phytofluene = plastoquinol-9 + 9,9',15-tri-cis-zeta-carotene

Direction not assertedBalancedRhea 30195

cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 ADP + 2 phosphate = reduced 2[4Fe-4S]-[ferredoxin] + benzoyl-CoA + 2 ATP + 2 H2O

Direction not assertedBalance undeterminableRhea 30199

P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = 2 GDP + 2 H(+)

Direction not assertedBalancedRhea 30203

2 oxidized [amicyanin] + methylamine + H2O = 2 reduced [amicyanin] + formaldehyde + NH4(+) + 2 H(+)

Direction not assertedBalance undeterminableRhea 30207

nitrous oxide + 2 Fe(III)-[cytochrome c] + H2O = 2 nitric oxide + 2 Fe(II)-[cytochrome c] + 2 H(+)

Direction not assertedBalance undeterminableRhea 30211

a menaquinol + 2 nitric oxide = nitrous oxide + a menaquinone + H2O

Direction not assertedBalance undeterminableRhea 30215

dimethyl sulfoxide + NAD(+) + H2O = dimethyl sulfone + NADH + H(+)

Direction not assertedBalancedRhea 30219

hydrogen sulfide + 2 Fe(III)-[cytochrome c] = sulfur + 2 Fe(II)-[cytochrome c] + H(+)

Direction not assertedBalance undeterminableRhea 30223

2 Fe(III)-[cytochrome c2] + dimethyl sulfide + H2O = 2 Fe(II)-[cytochrome c2] + dimethyl sulfoxide + 2 H(+)

Direction not assertedBalance undeterminableRhea 30227

S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2

Left to rightBalancedRhea 30231

L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)

Direction not assertedBalancedRhea 30235

n a quinone + n hydrogen sulfide + n H(+) = polysulfur(n-2) + n a quinol

Direction not assertedBalance undeterminableRhea 30239

4 L-ascorbate + O2 = 4 monodehydro-L-ascorbate radical + 2 H2O

Direction not assertedBalancedRhea 30243

2 plastoquinone-9 + 4 hnu + 2 H2O = 2 plastoquinol-9 + O2

Direction not assertedBalance undeterminableRhea 30247

2 a ubiquinol + O2 + n H(+)(in) = 2 a ubiquinone + 2 H2O + n H(+)(out)

Direction not assertedBalance undeterminableTransportRhea 30251

2 a ubiquinol + O2 = 2 a ubiquinone + 2 H2O

Direction not assertedBalance undeterminableRhea 30255

2 a menaquinol + O2 + n H(+)(in) = 2 a menaquinone + 2 H2O(in) + n H(+)(out)

Direction not assertedBalance undeterminableTransportRhea 30259

2 L-ascorbate + H2O2 = 2 monodehydro-L-ascorbate radical + 2 H2O

Direction not assertedBalancedRhea 30263

2 monodehydro-L-ascorbate radical = L-dehydroascorbate + L-ascorbate

Direction not assertedBalancedRhea 30267

2 (3,4-dimethoxyphenyl)methanol + H2O2 = 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O

Direction not assertedBalancedRhea 30271

H2O2 + AH2 = A + 2 H2O

Left to rightBalancedRhea 30275

2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin] + NAD(+) = 2 reduced [2Fe-2S]-[ferredoxin] + NADH + 3 H(+)

Direction not assertedBalance undeterminableRhea 30279

(-)-trans-permethrin + H2O = (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H(+)

Direction not assertedBalancedRhea 30283

2 a plastoquinone + 15-cis-phytoene = 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol

Direction not assertedBalance undeterminableRhea 30287

(9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate

Direction not assertedBalancedRhea 30291

GTP + pyruvate = phosphoenolpyruvate + GDP + H(+)

Direction not assertedBalancedRhea 30295

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