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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
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Reactions
Reach

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Cell types
Organisms
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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

401–450 of 18,558 reactions from Rhea

tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate
Left to rightBalancedRhea 11688
NAD(+) + NADPH = NADH + NADP(+)
Direction not assertedBalancedRhea 11692
3'-demethylstaurosporine + S-adenosyl-L-methionine = staurosporine + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 11696
progesterone + NADPH + O2 + H(+) = testosterone acetate + NADP(+) + H2O
Direction not assertedBalancedRhea 11700
N-(carboxyaminomethyl)urea + 2 H(+) = N-(aminomethyl)urea + CO2
Direction not assertedBalancedRhea 11704
IMP + NAD(+) + H2O = XMP + NADH + H(+)
Direction not assertedBalancedRhea 11708
3-methyl-2-oxobutanoate + 2 oxidized [2Fe-2S]-[ferredoxin] + CoA = 2-methylpropanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 11712

a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH4(+)

Left to rightBalance undeterminableRhea 11716

N-methylhydantoin + ATP + 2 H2O = N-carbamoylsarcosine + ADP + phosphate + 2 H(+)

Direction not assertedBalancedRhea 11720

[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate

Direction not assertedBalance undeterminableRhea 11724

cyclopentanol + NAD(+) = cyclopentanone + NADH + H(+)

Direction not assertedBalancedRhea 11728

sophoraflavanone B + reduced [NADPH--hemoprotein reductase] + O2 = leachianone G + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 11732

2-exo-hydroxy-1,8-cineole + NAD(+) = 6-oxocineole + NADH + H(+)

Direction not assertedBalancedRhea 11736

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)

Direction not assertedBalancedRhea 11740

thiamine triphosphate + H2O = thiamine diphosphate + phosphate + H(+)

Direction not assertedBalancedRhea 11744

fluoroacetaldehyde + L-threonine = 4-fluoro-L-threonine + acetaldehyde

Direction not assertedBalancedRhea 11748

acetylsalicylate + H2O = salicylate + acetate + H(+)

Direction not assertedBalancedRhea 11752

biotin + L-lysyl-[protein] + ATP = N(6)-biotinyl-L-lysyl-[protein] + AMP + diphosphate + H(+)

Left to rightBalance undeterminableRhea 11756

methylguanidine + H2O = urea + methylamine

Direction not assertedBalancedRhea 11764

N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate

Direction not assertedBalancedRhea 11768

6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH + H(+)

Direction not assertedBalancedRhea 11772

octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = (9Z)-octadecenoyl-[ACP] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 11776

3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 11780

L-aspartate + NADP(+) + H2O = oxaloacetate + NH4(+) + NADPH + H(+)

Direction not assertedBalancedRhea 11784

L-aspartate + NAD(+) + H2O = oxaloacetate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 11788

propene + NADH + O2 + H(+) = 1,2-epoxypropane + NAD(+) + H2O

Direction not assertedBalancedRhea 11792

ecdysone + O2 = 3-dehydroecdysone + H2O2

Direction not assertedBalancedRhea 11796

NAD(+) + H2O = beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)

Left to rightBalancedRhea 11800

an aromatic aldehyde + NAD(+) + H2O = an aromatic carboxylate + NADH + 2 H(+)

Direction not assertedBalance undeterminableRhea 11804

bergaptol + S-adenosyl-L-methionine = bergapten + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 11808

methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

Direction not assertedBalancedRhea 11812

alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate

ReversibleBalancedRhea 11816

diphthamide-[translation elongation factor 2] + NAD(+) = N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide + H(+)

Direction not assertedBalance undeterminableRhea 11820

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate

Direction not assertedBalancedRhea 11824

a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)

Left to rightBalance undeterminableRhea 11828

(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) = naphthalene-1,2-diol + NADH + H(+)

Direction not assertedBalancedRhea 11832

N-acetyllactosamine + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine + CMP + H(+)

Direction not assertedBalancedRhea 11836

benzaldehyde + NAD(+) + H2O = benzoate + NADH + 2 H(+)

Left to rightBalancedRhea 11840

formate + acetyl-CoA = pyruvate + CoA

Direction not assertedBalancedRhea 11844

acetyl phosphate + trimethylamine + [thioredoxin]-disulfide + H2O = glycine betaine + [thioredoxin]-dithiol + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 11848

S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine

Left to rightBalancedRhea 11852

1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 11856

L-histidyl-[protein] + ATP = N(tele)-phospho-L-histidyl-[protein] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 11860

trimethylamine + oxidized [electron-transfer flavoprotein] + H2O + H(+) = dimethylamine + reduced [electron-transfer flavoprotein] + formaldehyde

Direction not assertedBalance undeterminableRhea 11864

D-arabinitol + NADP(+) = D-ribulose + NADPH + H(+)

Direction not assertedBalancedRhea 11868

corticosterone + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 18-hydroxycorticosterone + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 11872

prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

Left to rightBalancedRhea 11876

(S)-6-hydroxynicotine + O2 + H2O = 6-hydroxypseudooxynicotine + H2O2

Direction not assertedBalancedRhea 11880

cortisol + 3'-phosphoadenylyl sulfate = cortisol 21-sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 11884

an aldehyde + NADP(+) + H2O = a carboxylate + NADPH + 2 H(+)

Left to rightBalance undeterminableRhea 11888

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