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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

4,401–4,450 of 18,558 reactions from Rhea

L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out)
Right to leftBalancedTransportRhea 29263
L-valine(in) + Na(+)(in) = L-valine(out) + Na(+)(out)
Direction not assertedBalancedTransportRhea 29267
trimethylamine N-oxide + a menaquinol + H(+) = trimethylamine + a menaquinone + H2O
Direction not assertedBalance undeterminableRhea 29271
L-isoleucine(in) + Na(+)(in) = L-isoleucine(out) + Na(+)(out)
Direction not assertedBalancedTransportRhea 29275
trimethylamine N-oxide + menaquinol-8 + H(+) = trimethylamine + menaquinone-8 + H2O
Direction not assertedBalancedRhea 29279
L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out)
Right to leftBalancedTransportRhea 29283
L-aspartate(in) + 2 H(+)(in) = L-aspartate(out) + 2 H(+)(out)

Direction not assertedBalancedTransportRhea 29287

(25S)-3-oxocholest-4-en-26-oate + ATP + CoA = (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 29291

aldehydo-D-galacturonate(out) + H(+)(out) = aldehydo-D-galacturonate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 29295

succinate(in) + 2 H(+)(in) = succinate(out) + 2 H(+)(out)

Left to rightBalancedTransportRhea 29303

methanesulfonate + FMNH2 + O2 = FMN + sulfite + formaldehyde + H2O + 2 H(+)

Direction not assertedBalancedRhea 29307

sulfoacetate + FMNH2 + O2 = FMN + sulfite + glyoxylate + H2O + 2 H(+)

Direction not assertedBalancedRhea 29311

alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate

Left to rightBalancedRhea 29315

sn-glycero-3-phosphoethanolamine + H2O = ethanolamine + sn-glycerol 3-phosphate + H(+)

Direction not assertedBalancedRhea 29319

fumarate(in) + succinate(out) = fumarate(out) + succinate(in)

Direction not assertedBalancedTransportRhea 29323

(S)-malate(in) + succinate(out) = (S)-malate(out) + succinate(in)

Direction not assertedBalancedTransportRhea 29327

fumarate(in) + 2 H(+)(in) = fumarate(out) + 2 H(+)(out)

Direction not assertedBalancedTransportRhea 29331

L-alanyl-L-glutamate + H2O = L-alanine + L-glutamate

Direction not assertedBalancedRhea 29335

(S)-malate(in) + 2 H(+)(in) = (S)-malate(out) + 2 H(+)(out)

Direction not assertedBalancedTransportRhea 29339

L-aspartate(in) + succinate(out) = L-aspartate(out) + succinate(in)

Direction not assertedBalancedTransportRhea 29343

orotate(in) + 2 H(+)(in) = orotate(out) + 2 H(+)(out)

Direction not assertedBalancedTransportRhea 29347

Zn(2+)(in) = Zn(2+)(out)

ReversibleBalancedTransportRhea 29351

dUMP + H2O = 2'-deoxyuridine + phosphate

Direction not assertedBalancedRhea 29355

UMP + H2O = uridine + phosphate

Direction not assertedBalancedRhea 29359

dCMP + H2O = 2'-deoxycytidine + phosphate

Direction not assertedBalancedRhea 29363

CMP + H2O = cytidine + phosphate

Direction not assertedBalancedRhea 29367

dAMP + H2O = 2'-deoxyadenosine + phosphate

Direction not assertedBalancedRhea 29371

AMP + H2O = adenosine + phosphate

Left to rightBalancedRhea 29375

dGMP + H2O = 2'-deoxyguanosine + phosphate

Left to rightBalancedRhea 29379

dIMP + H2O = 2'-deoxyinosine + phosphate

Left to rightBalancedRhea 29383

CTP + H2O = CDP + phosphate + H(+)

Left to rightBalancedRhea 29387

GTP + H2O = GMP + diphosphate + H(+)

Left to rightBalancedRhea 29391

UTP + H2O = UMP + diphosphate + H(+)

Left to rightBalancedRhea 29395

ITP + H2O = IMP + diphosphate + H(+)

Left to rightBalancedRhea 29399

5-methoxy-2-methyl-3-(all-trans-octaprenyl)benzene-1,4-diol + AH2 + O2 = 3-demethylubiquinol-8 + A + H2O

Direction not assertedBalancedRhea 29403

2-methoxy-6-(all-trans-octaprenyl)phenol + NADPH + O2 + H(+) = 2-methoxy-6-(all-trans-octaprenyl)benzene-1,4-diol + NADP(+) + H2O

Direction not assertedBalancedRhea 29407

glycolate(in) + H(+)(in) = glycolate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 29411

(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out)

ReversibleBalancedTransportRhea 29415

Na(+)(in) + H(+)(out) = Na(+)(out) + H(+)(in)

ReversibleBalancedTransportRhea 29419

diphosphate + ATP = triphosphate + ADP + H(+)

Direction not assertedBalancedRhea 29423

4-(trimethylamino)butanoate(in) + (R)-carnitine(out) = 4-(trimethylamino)butanoate(out) + (R)-carnitine(in)

Direction not assertedBalancedTransportRhea 29427

phosphate + ATP = ADP + diphosphate

Direction not assertedBalancedRhea 29431

enterobactin(in) + H(+)(out) = enterobactin(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 29435

Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 29439

L-alanine(in) + H(+)(in) = L-alanine(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 29443

glycolate(in) = glycolate(out)

Direction not assertedBalancedTransportRhea 29447

phosphonate + H2O = H2 + phosphate

Direction not assertedBalancedRhea 29451

D-serine(in) = D-serine(out)

Direction not assertedBalancedTransportRhea 29455

beta-alanine(in) + H(+)(in) = beta-alanine(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 29459

K(+)(in) = K(+)(out)

Direction not assertedBalancedTransportRhea 29463

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