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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

4,351–4,400 of 18,558 reactions from Rhea

ubiquinone-8 + H2 + 2 H(+)(in) = ubiquinol-8 + 2 H(+)(out)
Direction not assertedBalancedTransportRhea 29059
a menaquinone + formate + H(+) = a menaquinol + CO2
Direction not assertedBalance undeterminableRhea 29063
menaquinone-8 + formate + H(+) = menaquinol-8 + CO2
Direction not assertedBalancedRhea 29067
a ubiquinone + formate + H(+) = a ubiquinol + CO2
Direction not assertedBalance undeterminableRhea 29071
ubiquinone-8 + formate(out) + 2 H(+)(in) = ubiquinol-8 + CO2(out) + H(+)(out)
Direction not assertedBalancedTransportRhea 29075
ubiquinone-8 + (R)-lactate = ubiquinol-8 + pyruvate
Direction not assertedBalancedRhea 29079
ubiquinone-8 + (S)-malate = ubiquinol-8 + oxaloacetate

Direction not assertedBalancedRhea 29083

menaquinone-8 + (S)-malate = menaquinol-8 + oxaloacetate

Direction not assertedBalancedRhea 29087

a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)

Left to rightBalance undeterminableTransportRhea 29091

ubiquinone-8 + NADH + 5 H(+)(in) = ubiquinol-8 + NAD(+) + 4 H(+)(out)

Direction not assertedBalancedTransportRhea 29095

a menaquinone + NADH + 5 H(+)(in) = a menaquinol + NAD(+) + 4 H(+)(out)

Direction not assertedBalance undeterminableTransportRhea 29099

menaquinone-8 + NADH + 5 H(+)(in) = menaquinol-8 + NAD(+) + 4 H(+)(out)

Direction not assertedBalancedTransportRhea 29103

ubiquinone-8 + NADH + H(+) = ubiquinol-8 + NAD(+)

Direction not assertedBalancedRhea 29107

ubiquinone-8 + NADPH + H(+) = ubiquinol-8 + NADP(+)

Direction not assertedBalancedRhea 29111

menaquinone-8 + NADPH + H(+) = menaquinol-8 + NADP(+)

Direction not assertedBalancedRhea 29115

a ubiquinol + nitrate = a ubiquinone + nitrite + H2O

Direction not assertedBalance undeterminableRhea 29119

ubiquinol-8(in) + nitrate(out) = ubiquinone-8(in) + nitrite(out) + H2O(out)

Direction not assertedBalancedRhea 29123

a menaquinol + nitrate = a menaquinone + nitrite + H2O

Direction not assertedBalance undeterminableRhea 29127

menaquinol-8 + nitrate = menaquinone-8 + nitrite + H2O

Direction not assertedBalancedRhea 29131

a menaquinol + nitrate + 2 H(+)(in) = a menaquinone + nitrite + H2O + 2 H(+)(out)

Direction not assertedBalance undeterminableTransportRhea 29135

menaquinol-8 + nitrate + 2 H(+)(in) = menaquinone-8 + nitrite + H2O + 2 H(+)(out)

Direction not assertedBalancedTransportRhea 29139

a ubiquinol + nitrate + 2 H(+)(in) = a ubiquinone + nitrite + H2O + 2 H(+)(out)

Direction not assertedBalance undeterminableTransportRhea 29143

ubiquinol-8 + nitrate + 2 H(+)(in) = ubiquinone-8 + nitrite + H2O + 2 H(+)(out)

Direction not assertedBalancedTransportRhea 29147

3 a ubiquinol(in) + nitrite(out) + 2 H(+)(out) = 3 a ubiquinone(in) + NH4(+)(out) + 2 H2O(out)

Direction not assertedBalance undeterminableRhea 29151

3 ubiquinol-8(in) + nitrite(out) + 2 H(+)(out) = 3 ubiquinone-8(in) + NH4(+)(out) + 2 H2O(out)

Direction not assertedBalancedRhea 29155

3 a menaquinol(in) + nitrite(out) + 2 H(+)(out) = 3 a menaquinone(in) + NH4(+)(out) + 2 H2O(out)

Direction not assertedBalance undeterminableRhea 29159

3 menaquinol-8(in) + nitrite(out) + 2 H(+)(out) = 3 menaquinone-8(in) + NH4(+)(out) + 2 H2O(out)

Direction not assertedBalancedRhea 29163

a ubiquinol + 2 O2 = 2 superoxide + a ubiquinone + 2 H(+)

Direction not assertedBalance undeterminableRhea 29171

ubiquinol-8 + 2 O2 = 2 superoxide + ubiquinone-8 + 2 H(+)

Direction not assertedBalancedRhea 29175

a menaquinol + 2 O2 = 2 superoxide + a menaquinone + 2 H(+)

Direction not assertedBalance undeterminableRhea 29179

menaquinol-8 + 2 O2 = 2 superoxide + menaquinone-8 + 2 H(+)

Direction not assertedBalancedRhea 29183

ubiquinone-8 + succinate = ubiquinol-8 + fumarate

Direction not assertedBalancedRhea 29187

menaquinone-8 + L-aspartate = iminosuccinate + menaquinol-8

Direction not assertedBalancedRhea 29191

(S)-dihydroorotate + a menaquinone = orotate + a menaquinol

Direction not assertedBalance undeterminableRhea 29195

(S)-dihydroorotate + menaquinone-8 = orotate + menaquinol-8

Direction not assertedBalancedRhea 29199

dimethyl sulfoxide + menaquinol-8 = dimethyl sulfide + menaquinone-8 + H2O

Direction not assertedBalancedRhea 29203

dimethyl sulfoxide(out) + a menaquinol(in) = dimethyl sulfide(out) + a menaquinone(in) + H2O(out)

Direction not assertedBalance undeterminableRhea 29207

inosine(in) + H(+)(out) = inosine(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 29211

menaquinol-8 + fumarate = menaquinone-8 + succinate

Direction not assertedBalancedRhea 29215

a menaquinone + sn-glycerol 3-phosphate = a menaquinol + dihydroxyacetone phosphate

Direction not assertedBalance undeterminableRhea 29219

menaquinone-8 + sn-glycerol 3-phosphate = menaquinol-8 + dihydroxyacetone phosphate

Direction not assertedBalancedRhea 29223

indole(in) + H(+)(in) = indole(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 29227

cyanate(in) = cyanate(out)

Direction not assertedBalancedTransportRhea 29231

a menaquinone + NADH + H(+) = a menaquinol + NAD(+)

Direction not assertedBalance undeterminableRhea 29235

uracil(in) + H(+)(in) = uracil(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 29239

menaquinone-8 + NADH + H(+) = menaquinol-8 + NAD(+)

Direction not assertedBalancedRhea 29243

2 Na(+)(in) + 3 H(+)(out) = 2 Na(+)(out) + 3 H(+)(in)

Direction not assertedBalancedTransportRhea 29247

Na(+)(in) + 2 H(+)(out) = Na(+)(out) + 2 H(+)(in)

Direction not assertedBalancedTransportRhea 29251

Ca(2+)(in) + Na(+)(out) = Ca(2+)(out) + Na(+)(in)

Direction not assertedBalancedTransportRhea 29255

(2R,3R)-tartrate(out) + succinate(in) = (2R,3R)-tartrate(in) + succinate(out)

Direction not assertedBalancedTransportRhea 29259

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