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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Processes
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Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

4,251–4,300 of 18,558 reactions from Rhea

glutathione S,S-dioxide + H2O = sulfite + glutathione + H(+)
Direction not assertedBalancedRhea 28655
beta-lactose + H2O = beta-D-galactose + beta-D-glucose
Direction not assertedBalancedRhea 28659
melibiose + H2O = D-galactose + D-glucose
Direction not assertedBalancedRhea 28663
hydroxyacetone + NADH + H(+) = (S)-propane-1,2-diol + NAD(+)
Direction not assertedBalancedRhea 28667
2 cob(II)alamin + reduced [electron-transfer flavoprotein] + 2 ATP = 2 adenosylcob(III)alamin + 2 triphosphate + oxidized [electron-transfer flavoprotein] + 3 H(+)
Direction not assertedBalance undeterminableRhea 28671
alpha-D-galactose = beta-D-galactose
Right to leftBalancedRhea 28675
3-demethylubiquinol-8 + S-adenosyl-L-methionine = ubiquinol-8 + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 28679

ubiquinone-8 + L-aspartate = iminosuccinate + ubiquinol-8

Direction not assertedBalancedRhea 28683

(S)-dihydroorotate + ubiquinone-8 = ubiquinol-8 + orotate

Direction not assertedBalancedRhea 28687

(S)-dihydroorotate + a ubiquinone = orotate + a ubiquinol

Direction not assertedBalance undeterminableRhea 28691

hydrogencarbonate(in) = hydrogencarbonate(out)

Right to leftBalancedTransportRhea 28695

Mn(2+)(in) = Mn(2+)(out)

Direction not assertedBalancedTransportRhea 28699

Cu(2+)(in) = Cu(2+)(out)

Right to leftBalancedTransportRhea 28703

Cd(2+)(in) = Cd(2+)(out)

Direction not assertedBalancedTransportRhea 28707

N-(4-aminobenzoyl)-L-glutamate(in) + H(+)(in) = N-(4-aminobenzoyl)-L-glutamate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 28711

(R)-malate(in) + 2 H(+)(in) = (R)-malate(out) + 2 H(+)(out)

Direction not assertedBalancedTransportRhea 28715

adenine(in) + H(+)(in) = adenine(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 28719

(S)-allantoin(in) + H(+)(in) = (S)-allantoin(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 28723

Cu(2+)(in) + H(+)(in) = Cu(2+)(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 28727

L-leucine(in) + H(+)(out) = L-leucine(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 28731

spermidine(out) + H(+)(in) = spermidine(in) + H(+)(out)

Direction not assertedBalancedTransportRhea 28735

Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 28739

nitrate(in) + nitrite(out) = nitrate(out) + nitrite(in)

Direction not assertedBalancedTransportRhea 28743

NH4(+)(in) = NH4(+)(out)

ReversibleBalancedTransportRhea 28747

ubiquinone-8 + sn-glycerol 3-phosphate = ubiquinol-8 + dihydroxyacetone phosphate

Direction not assertedBalancedRhea 28751

a ubiquinone + sn-glycerol 3-phosphate = a ubiquinol + dihydroxyacetone phosphate

Direction not assertedBalance undeterminableRhea 28755

beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose = alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)

Direction not assertedBalancedRhea 28759

ethylnitronate + O2 = chemical entity + acetaldehyde + nitrite + H(+)

Direction not assertedBalance undeterminableRhea 28767

(2E)-hexadecenoyl-CoA = (9Z)-hexadecenoyl-CoA

Direction not assertedBalancedRhea 28771

dinoflagellate luciferin + O2 = oxidized dinoflagellate luciferin + hnu + H2O + H(+)

Direction not assertedBalance undeterminableRhea 28775

4-hydroxy-L-threonine = glycolaldehyde + glycine

Direction not assertedBalancedRhea 28779

L-cysteinylglycine + H2O = L-cysteine + glycine

Left to rightBalancedRhea 28783

4-hydroxy-L-threonine + ATP = 4-(phosphooxy)-L-threonine + ADP + H(+)

Direction not assertedBalancedRhea 28787

5,6-dihydrothymine + NAD(+) = thymine + NADH + H(+)

Direction not assertedBalancedRhea 28791

2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH

Direction not assertedBalancedRhea 28795

L-prolinylglycine + H2O = L-proline + glycine

Direction not assertedBalancedRhea 28799

L-ascorbate 6-phosphate + H2O = 3-dehydro-L-gulonate 6-phosphate

Direction not assertedBalancedRhea 28803

glutathione + H2O = L-cysteinylglycine + L-glutamate

Left to rightBalancedRhea 28807

2,3-dioxo-L-gulonate(in) + Na(+)(in) = 2,3-dioxo-L-gulonate(out) + Na(+)(out)

Direction not assertedBalancedTransportRhea 28811

4-hydroxybenzoate(in) + H(+)(out) = 4-hydroxybenzoate(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 28815

5-dehydro-D-gluconate(in) + H(+)(in) = 5-dehydro-D-gluconate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 28819

L-galactonate(in) + H(+)(in) = L-galactonate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 28823

putrescine(in) + L-ornithine(out) = putrescine(out) + L-ornithine(in)

Direction not assertedBalancedTransportRhea 28827

D-gluconate(in) + H(+)(in) = D-gluconate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 28831

citrate(out) + succinate(in) = citrate(in) + succinate(out)

Direction not assertedBalancedTransportRhea 28835

Zn(2+)(in) + H(+)(out) = Zn(2+)(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 28839

choline(in) + H(+)(in) = choline(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 28843

melibiose(in) + Li(+)(in) = melibiose(out) + Li(+)(out)

Direction not assertedBalancedTransportRhea 28847

melibiose(in) + Na(+)(in) = melibiose(out) + Na(+)(out)

Direction not assertedBalancedTransportRhea 28851

melibiose(in) + H(+)(in) = melibiose(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 28855

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