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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Interactions
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Reactions
Reach

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Organisms
Materials
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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

4,151–4,200 of 18,558 reactions from Rhea

L-glutamate 5-semialdehyde = (S)-1-pyrroline-5-carboxylate + H2O + H(+)
Direction not assertedBalancedRhea 28234
calycosin + reduced [NADPH--hemoprotein reductase] + O2 = pseudobaptigenin + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 28238
pratensein + reduced [NADPH--hemoprotein reductase] + O2 = 5-hydroxypseudobaptigenin + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 28242
(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)
Direction not assertedBalancedRhea 28246
malonyl-CoA + acetyl-CoA + H(+) = acetoacetyl-CoA + CO2 + CoA
Direction not assertedBalancedRhea 28250
(3Z)-hex-3-en-1-ol + acetyl-CoA = (3Z)-hex-3-en-1-yl acetate + CoA
Direction not assertedBalancedRhea 28254

cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate = cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 28258

3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose = 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + UMP + H(+)

Direction not assertedBalancedRhea 28262

(2E,6E)-farnesyl diphosphate = (S)-beta-bisabolene + diphosphate

Direction not assertedBalancedRhea 28266

spermidine + acetyl-CoA = N(8)-acetylspermidine + CoA + H(+)

Left to rightBalancedRhea 28270

(S)-S-adenosyl-L-methionine = (R)-S-adenosyl-L-methionine

Direction not assertedBalancedRhea 28274

3-sulfino-L-alanine + H2O = sulfite + L-alanine + H(+)

Direction not assertedBalancedRhea 28278

(S)-beta-bisabolene = (S)-beta-macrocarpene

Direction not assertedBalancedRhea 28282

a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 28286

(2E,6E)-farnesyl diphosphate + H2O = (5S,9S,10S)-drim-7-en-11-ol + diphosphate

Direction not assertedBalancedRhea 28290

(2E,6E)-farnesyl diphosphate = (-)-(E)-beta-caryophyllene + diphosphate

Direction not assertedBalancedRhea 28294

(2E,6E)-farnesyl diphosphate = (E)-gamma-bisabolene + diphosphate

Direction not assertedBalancedRhea 28298

(2E,6E)-farnesyl diphosphate = germacrene C + diphosphate

Direction not assertedBalancedRhea 28302

beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)

Direction not assertedBalancedRhea 28306

beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)

Direction not assertedBalancedRhea 28310

baicalein + UDP-alpha-D-glucuronate = baicalin + UDP

Direction not assertedBalancedRhea 28314

scutellarein + UDP-alpha-D-glucuronate = scutellarin + UDP

Direction not assertedBalancedRhea 28318

wogonin + UDP-alpha-D-glucuronate = wogonin 7-O-beta-D-glucuronate + UDP

Direction not assertedBalancedRhea 28322

wogonin 7-O-beta-D-glucuronate + H2O = wogonin + D-glucuronate + H(+)

Direction not assertedBalancedRhea 28326

ITP + H2O = IDP + phosphate + H(+)

Left to rightBalancedRhea 28330

dATP + H2O = dAMP + diphosphate + H(+)

Direction not assertedBalancedRhea 28334

(R)-carnitinyl-CoA = crotonobetainyl-CoA + H2O

Direction not assertedBalancedRhea 28338

dITP + H2O = dIMP + diphosphate + H(+)

Left to rightBalancedRhea 28342

7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate

Direction not assertedBalancedRhea 28346

UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose

Direction not assertedBalancedRhea 28350

decanoyl-CoA + FAD + H(+) = (2E)-decenoyl-CoA + FADH2

Direction not assertedBalancedRhea 28354

tetradecanoyl-CoA + FAD + H(+) = (2E)-tetradecenoyl-CoA + FADH2

Direction not assertedBalancedRhea 28358

dGTP + H2O = dGMP + diphosphate + H(+)

Left to rightBalancedRhea 28362

UDP-N-acetyl-alpha-D-mannosaminouronate + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP + H(+)

Direction not assertedBalancedRhea 28366

oxaloacetate + phosphate = phosphoenolpyruvate + hydrogencarbonate

Direction not assertedBalancedRhea 28370

D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 28374

N(6)-(D-fructosyl)-L-lysine + ATP = N(6)-(6-phospho-D-fructosyl)-L-lysine + ADP + H(+)

Direction not assertedBalancedRhea 28378

N(6)-(6-phospho-D-fructosyl)-L-lysine + H2O = D-glucose 6-phosphate + L-lysine

Direction not assertedBalancedRhea 28382

UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + di-trans,octa-cis-undecaprenyl phosphate = di-trans,octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP

Direction not assertedBalancedRhea 28386

N(6)-(D-psicosyl)-L-lysine = N(6)-(D-fructosyl)-L-lysine

Direction not assertedBalancedRhea 28390

L-alanyl-L-glutamate = L-alanyl-D-glutamate

Direction not assertedBalancedRhea 28394

L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate + H2O = L-alanyl-D-glutamate + meso-2,6-diaminopimelate

Direction not assertedBalancedRhea 28398

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + ADP-L-glycero-beta-D-manno-heptose = L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) + ADP + H(+)

Direction not assertedBalancedRhea 28402

XTP + H2O = XDP + phosphate + H(+)

Direction not assertedBalancedRhea 28406

4-(gamma-L-glutamylamino)butanal + NADP(+) + H2O = 4-(gamma-L-glutamylamino)butanoate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 28410

gamma-L-glutamylputrescine + O2 + H2O = 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)

Direction not assertedBalancedRhea 28414

4-(trimethylamino)butanoyl-CoA + (R)-carnitine = (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate

Direction not assertedBalancedRhea 28418

(1E,2S)-2-methylbutanal oxime + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxy-2-methylbutanenitrile + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 28422

D-allulose 6-phosphate = keto-D-fructose 6-phosphate

Direction not assertedBalancedRhea 28426

D-allose 6-phosphate = D-allulose 6-phosphate

Direction not assertedBalancedRhea 28430

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