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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

4,101–4,150 of 18,558 reactions from Rhea

dGDP + [thioredoxin]-disulfide + H2O = [thioredoxin]-dithiol + GDP
Direction not assertedBalance undeterminableRhea 28030
dADP + [thioredoxin]-disulfide + H2O = [thioredoxin]-dithiol + ADP
Direction not assertedBalance undeterminableRhea 28034
dCDP + [thioredoxin]-disulfide + H2O = CDP + [thioredoxin]-dithiol
Direction not assertedBalance undeterminableRhea 28038
pyruvate + NAD(+) + CoA = acetyl-CoA + CO2 + NADH
Direction not assertedBalancedRhea 28042
propanoyl-CoA + phosphate = propanoyl phosphate + CoA
Direction not assertedBalancedRhea 28046
NADP(+) + H2O = phosphate + NAD(+)
Left to rightBalancedRhea 28050
2-oxobutanoate + CoA = propanoyl-CoA + formate

? Direction not asserted

Balanced

Rhea 28054

L-lyxopyranose = L-xylulose

Direction not assertedBalancedRhea 28058

alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)

Direction not assertedBalancedRhea 28062

lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)

Direction not assertedBalancedRhea 28066

heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate

Direction not assertedBalancedRhea 28070

(2R)-3-sulfopropanediol + 2 NAD(+) + H2O = (2R)-3-sulfolactate + 2 NADH + 3 H(+)

Direction not assertedBalancedRhea 28074

2-hydroxyethylphosphonate + NAD(+) = phosphonoacetaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 28078

(2S)-ethylmalonyl-CoA + NADP(+) = (2E)-butenoyl-CoA + CO2 + NADPH

Direction not assertedBalancedRhea 28082

Reactive Blue 5 + 2 H2O2 = 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + phthalate + 2 H2O + 2 H(+)

Direction not assertedBalancedRhea 28086

di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP

Direction not assertedBalancedRhea 28090

di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + phosphate + H(+)

Direction not assertedBalancedRhea 28094

GDP + ATP = guanosine 3',5'-bis(diphosphate) + AMP

Direction not assertedBalancedRhea 28098

GDP-alpha-D-mannose + H2O = D-mannose + GDP + H(+)

Direction not assertedBalancedRhea 28102

galactitol 1-phosphate + NAD(+) = keto-D-tagatose 6-phosphate + NADH + H(+)

Direction not assertedBalancedRhea 28106

chloride + S-adenosyl-L-methionine = 5'-chloro-5'-deoxyadenosine + L-methionine

Direction not assertedBalancedRhea 28110

di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP

Direction not assertedBalancedRhea 28118

di-trans,octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H(+)

Direction not assertedBalancedRhea 28122

di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP

Direction not assertedBalancedRhea 28126

baicalin + H2O = baicalein + D-glucuronate + H(+)

Direction not assertedBalancedRhea 28130

(2S)-hesperidin + H2O = rutinose + (2S)-hesperetin

Direction not assertedBalancedRhea 28134

streptothricin F + H2O = streptothricin F acid

Direction not assertedBalancedRhea 28138

streptothricin D + H2O = streptothricin D acid

Direction not assertedBalancedRhea 28142

(2E)-geranylhydroquinone + reduced [NADPH--hemoprotein reductase] + O2 = (2Z)-3''-hydroxygeranylhydroquinone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 28146

spermidine + acetyl-CoA = N(1)-acetylspermidine + CoA + H(+)

Left to rightBalancedRhea 28150

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)

Direction not assertedBalancedRhea 28154

alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)

Direction not assertedBalancedRhea 28158

cytidine + GTP = GDP + CMP + H(+)

Direction not assertedBalancedRhea 28162

5-nitroanthranilate + H2O + H(+) = 5-nitrosalicylate + NH4(+)

Direction not assertedBalancedRhea 28166

(2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide

Direction not assertedBalancedRhea 28170

(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = colneleate + H2O

Direction not assertedBalancedRhea 28174

(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate = colnelenate + H2O

Direction not assertedBalancedRhea 28178

(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate = (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate

Direction not assertedBalancedRhea 28182

aminoacetone + O2 + H2O = methylglyoxal + H2O2 + NH4(+)

Direction not assertedBalancedRhea 28186

2'-deoxyadenosine + H2O + H(+) = 2'-deoxyinosine + NH4(+)

Left to rightBalancedRhea 28190

(2S)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + NADH + H(+)

Direction not assertedBalancedRhea 28194

(S)-1-phenylethanol + NAD(+) = acetophenone + NADH + H(+)

Direction not assertedBalancedRhea 28198

chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 ADP + 2 phosphate = protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin] + 2 ATP + 2 H2O

Direction not assertedBalance undeterminableRhea 28202

2'-deoxyuridine + ATP = dUMP + ADP + H(+)

Left to rightBalancedRhea 28206

L-saccharopine + O2 + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + H2O2

Direction not assertedBalancedRhea 28210

prostaglandin H2 + [thioredoxin]-dithiol = prostaglandin F2alpha + [thioredoxin]-disulfide

Direction not assertedBalance undeterminableRhea 28214

chloride + H2O2 + H(+) = hypochlorous acid + H2O

Left to rightBalancedRhea 28218

3-dehydro-L-gulonate + ATP = 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 28222

(+)-5-epi-aristolochene + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = capsidiol + 2 oxidized [NADPH--hemoprotein reductase] + 2 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 28226

germacra-1(10),4,11(13)-trien-12-oate + reduced [NADPH--hemoprotein reductase] + O2 = (+)-costunolide + oxidized [NADPH--hemoprotein reductase] + 2 H2O

Direction not assertedBalance undeterminableRhea 28230

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