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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

4,051–4,100 of 18,558 reactions from Rhea

O-succinyl-L-homoserine + hydrogen sulfide = L-homocysteine + succinate
Direction not assertedBalancedRhea 27826
neryl diphosphate = beta-phellandrene + diphosphate
Direction not assertedBalancedRhea 27830
a menaquinone + succinate = a menaquinol + fumarate
Direction not assertedBalance undeterminableRhea 27834
9H-carbazole + NADH + O2 + H(+) = 2'-aminobiphenyl-2,3-diol + NAD(+)
Direction not assertedBalancedRhea 27838
9H-carbazole + NADPH + O2 + H(+) = 2'-aminobiphenyl-2,3-diol + NADP(+)
Direction not assertedBalancedRhea 27842
(2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + O2 + H(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NAD(+) + H2O
Direction not assertedBalancedRhea 27846
phenylacetyl-CoA + glycine = phenylacetylglycine + CoA + H(+)

Direction not assertedBalancedRhea 27850

4-hydroxybenzoate + (2E)-geranyl diphosphate = 3-geranyl-4-hydroxybenzoate + diphosphate

Direction not assertedBalancedRhea 27854

2',3'-cyclophospho-GMP + H2O = 3'-GMP + H(+)

Direction not assertedBalancedRhea 27858

3'-GMP + H2O = guanosine + phosphate

Direction not assertedBalancedRhea 27862

(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O = alpha-D-mannose 6-phosphate + (R)-glycerate

Direction not assertedBalancedRhea 27866

(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)

Direction not assertedBalancedRhea 27870

isochorismate = salicylate + pyruvate

Direction not assertedBalancedRhea 27874

2',3'-cyclophospho-UMP + H2O = 3'-UMP + H(+)

Direction not assertedBalancedRhea 27878

2',3'-cyclophospho-CMP + H2O = 3'-CMP + H(+)

Direction not assertedBalancedRhea 27882

2',3'-cyclophospho-AMP + H2O = 3'-AMP + H(+)

Direction not assertedBalancedRhea 27886

3'-UMP + H2O = uridine + phosphate

Direction not assertedBalancedRhea 27890

3'-CMP + H2O = cytidine + phosphate

Direction not assertedBalancedRhea 27894

3'-AMP + H2O = adenosine + phosphate

Direction not assertedBalancedRhea 27898

ubiquinone-0 + caffeine + H2O = ubiquinol-0 + 1,3,7-trimethylurate

Direction not assertedBalancedRhea 27902

butanoyl-CoA + NADP(+) = (2E)-butenoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 27906

4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + phosphate + H(+)

Direction not assertedBalancedRhea 27914

propanal + NADP(+) + H2O = propanoate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 27918

5-methylsulfanyl-2,3-dioxopentyl phosphate + O2 + H2O = 4-methylsulfanyl-2-oxobutanoate + formate + phosphate + 2 H(+)

Direction not assertedBalancedRhea 27922

UMP(in) = UMP(out)

Direction not assertedBalancedTransportRhea 27926

(R)-4-phosphopantoate + beta-alanine + ATP = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 27930

(3S)-3-hydroxy-D-aspartate = glyoxylate + glycine

Direction not assertedBalancedRhea 27934

(3R)-3-hydroxy-D-aspartate = glyoxylate + glycine

Direction not assertedBalancedRhea 27938

(3R)-3-hydroxy-D-aspartate = oxaloacetate + NH4(+)

Direction not assertedBalancedRhea 27942

dopamine + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)

Direction not assertedBalancedRhea 27946

L-phenylalanine(in) = L-phenylalanine(out)

ReversibleBalancedTransportRhea 27950

(2E,6E)-farnesyl diphosphate + H2O = presilphiperfolan-8beta-ol + diphosphate

Direction not assertedBalancedRhea 27954

cytidine + H2O = cytosine + D-ribose

Direction not assertedBalancedRhea 27958

pyrroloquinoline quinone + myo-inositol = pyrroloquinoline quinol + scyllo-inosose + H(+)

Direction not assertedBalancedRhea 27962

7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H(+)

Direction not assertedBalancedRhea 27966

D-maltotriose + H2O = D-maltose + alpha-D-glucose

Left to rightBalancedRhea 27970

6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-carbaguanine + NH4(+)

Direction not assertedBalancedRhea 27974

GDP-alpha-D-mannose + H2O = alpha-D-mannose 1-phosphate + GMP + 2 H(+)

Direction not assertedBalancedRhea 27978

7-carboxy-7-carbaguanine + NH4(+) + 2 ATP = 7-cyano-7-carbaguanine + 2 AMP + 2 diphosphate + 2 H(+)

Direction not assertedBalancedRhea 27982

hydroxyacetone + NADP(+) = methylglyoxal + NADPH + H(+)

Right to leftBalancedRhea 27986

1-deoxy-D-xylulose + ATP = 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 27990

xanthosine + H2O = D-ribose + xanthine

Direction not assertedBalancedRhea 27994

thiamine diphosphate + H2O = thiamine phosphate + phosphate + H(+)

Direction not assertedBalancedRhea 27998

beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate

Direction not assertedBalancedRhea 28002

N(alpha)-methyl-L-tryptophan + O2 + H2O = L-tryptophan + formaldehyde + H2O2

Direction not assertedBalancedRhea 28006

propanoyl-CoA + succinate = propanoate + succinyl-CoA

Direction not assertedBalancedRhea 28010

thiocyanate + S-adenosyl-L-methionine = methyl thiocyanate + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 28014

enterobactin + 3 H2O = 3 N-(2,3-dihydroxybenzoyl)-L-serine + 2 H(+)

Direction not assertedBalancedRhea 28018

octanoate + holo-[ACP] + ATP = octanoyl-[ACP] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 28022

dUDP + [thioredoxin]-disulfide + H2O = [thioredoxin]-dithiol + UDP

Direction not assertedBalance undeterminableRhea 28026

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