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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

4,001–4,050 of 18,558 reactions from Rhea

geranylgeranyl diphosphate + 7 isopentenyl diphosphate = tri-trans,hepta-cis-undecaprenyl diphosphate + 7 diphosphate
Direction not assertedBalancedRhea 27622
D-erythrose 4-phosphate + D-xylulose 5-phosphate = beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate
Direction not assertedBalancedRhea 27626
ethylene glycol + NAD(+) = glycolaldehyde + NADH + H(+)
Direction not assertedBalancedRhea 27630
5-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + NADPH + H(+)
Direction not assertedBalancedRhea 27634
xanthosine + phosphate = alpha-D-ribose 1-phosphate + xanthine
Direction not assertedBalancedRhea 27638
adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine
Left to rightBalancedRhea 27642
inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine

Left to rightBalancedRhea 27646

uridine + GTP = UMP + GDP + H(+)

Direction not assertedBalancedRhea 27650

2-oxobutanoate + pyruvate + H(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2

Direction not assertedBalancedRhea 27654

2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate

Direction not assertedBalancedRhea 27658

(S)-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2

Direction not assertedBalancedRhea 27662

(R)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2

Direction not assertedBalancedRhea 27666

1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate

Left to rightBalancedRhea 27670

dADP + ATP = dATP + ADP

Direction not assertedBalancedRhea 27674

dCDP + ATP = dCTP + ADP

ReversibleBalancedRhea 27678

dTDP + ATP = dTTP + ADP

Left to rightBalancedRhea 27682

GDP + ATP = GTP + ADP

Left to rightBalancedRhea 27686

dGDP + ATP = dGTP + ADP

Left to rightBalancedRhea 27690

(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O

Direction not assertedBalancedRhea 27694

GDP-beta-L-galactose + phosphate = beta-L-galactose 1-phosphate + GDP + H(+)

Direction not assertedBalancedRhea 27698

aldehydo-D-galacturonate = keto-D-tagaturonate

Direction not assertedBalancedRhea 27702

D-serine + D-alanine + ATP = D-alanyl-D-serine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 27706

guanosine + ATP = GMP + ADP + H(+)

Direction not assertedBalancedRhea 27710

GMP + H2O = guanosine + phosphate

Left to rightBalancedRhea 27714

IMP + H2O = inosine + phosphate

Left to rightBalancedRhea 27718

UDP-4-deoxy-4-formamido-beta-L-arabinose + di-trans,octa-cis-undecaprenyl phosphate = 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP

Direction not assertedBalancedRhea 27722

5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate

Direction not assertedBalancedRhea 27726

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) = beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate

Direction not assertedBalancedRhea 27730

4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate

Direction not assertedBalancedRhea 27734

2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine

Direction not assertedBalancedRhea 27738

2'-deoxyadenosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + adenine

Direction not assertedBalancedRhea 27742

L-cysteine + H(+) = cysteamine + CO2

Direction not assertedBalancedRhea 27746

2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine

Direction not assertedBalancedRhea 27750

methylglyoxal + H2O = (R)-lactate + H(+)

Direction not assertedBalancedRhea 27754

(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+) + CO2 + NADH

Direction not assertedBalancedRhea 27758

CTP + H2O = CMP + diphosphate + H(+)

Left to rightBalancedRhea 27762

3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 27770

2-methoxy-6-(all-trans-octaprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = 5-methoxy-2-methyl-3-(all-trans-octaprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 27774

4-hydroxy-3-(all-trans-octaprenyl)benzoate + H(+) = 2-all-trans-octaprenylphenol + CO2

Direction not assertedBalancedRhea 27778

all-trans-octaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-octaprenyl)benzoate + diphosphate

Direction not assertedBalancedRhea 27782

2-oxoglutarate + NAD(+) + CoA = succinyl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 27786

2-all-trans-octaprenylphenol + NADPH + O2 + H(+) = 3-(all-trans-octaprenyl)benzene-1,2-diol + NADP(+) + H2O

Direction not assertedBalancedRhea 27790

4 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-heptaprenyl diphosphate + 4 diphosphate

Direction not assertedBalancedRhea 27794

5 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-octaprenyl diphosphate + 5 diphosphate

Direction not assertedBalancedRhea 27798

7 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate

Left to rightBalancedRhea 27802

acetoacetate + acetyl-CoA = acetoacetyl-CoA + acetate

Direction not assertedBalancedRhea 27806

2 isopentenyl diphosphate + dimethylallyl diphosphate = (2Z,6Z)-farnesyl diphosphate + 2 diphosphate

Direction not assertedBalancedRhea 27810

acetate(in) + Na(+)(in) = acetate(out) + Na(+)(out)

Direction not assertedBalancedTransportRhea 27814

L-idonate + NAD(+) = 2-dehydro-L-idonate + NADH + H(+)

Direction not assertedBalancedRhea 27818

O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate

Direction not assertedBalancedRhea 27822

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