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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,951–4,000 of 18,558 reactions from Rhea

codeine + 2-oxoglutarate + O2 = morphine + formaldehyde + succinate + CO2
Direction not assertedBalancedRhea 27413
2 Fe(III)-[cytochrome] + nicotinate + H2O = 2 Fe(II)-[cytochrome] + 6-hydroxynicotinate + 2 H(+)
Direction not assertedBalance undeterminableRhea 27417
(2E,6E)-farnesyl diphosphate = (3E,6E)-alpha-farnesene + diphosphate
Direction not assertedBalancedRhea 27421
(2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate
Direction not assertedBalancedRhea 27425
a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate
Left to rightBalance undeterminableRhea 27429
2 glutathione amide + NAD(+) = glutathione amide disulfide + NADH + H(+)
Direction not assertedBalancedRhea 27433
2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O

Direction not assertedBalancedRhea 27437

xylitol + NAD(+) = D-xylose + NADH + H(+)

Direction not assertedBalancedRhea 27441

xylitol + NADP(+) = D-xylose + NADPH + H(+)

Direction not assertedBalancedRhea 27445

a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H(+)

Left to rightBalance undeterminableRhea 27449

iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH

Right to leftBalancedRhea 27453

3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + NADPH + H(+)

Right to leftBalancedRhea 27457

D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) = GDP-D-glycero-alpha-D-manno-heptose + diphosphate

Direction not assertedBalancedRhea 27461

D-glycero-beta-D-manno-heptose 1-phosphate + ATP + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate

Direction not assertedBalancedRhea 27465

N,N'-diacetylchitobiose + H2O = N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine + acetate

Direction not assertedBalancedRhea 27469

D-glycero-beta-D-manno-heptose 7-phosphate + ATP = D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 27473

thebaine + 2-oxoglutarate + O2 = neopinone + formaldehyde + succinate + CO2

Direction not assertedBalancedRhea 27477

(S)-columbianetin + reduced [NADPH--hemoprotein reductase] + O2 = angelicin + acetone + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 27481

allantoate + H2O + 2 H(+) = (S)-2-ureidoglycine + NH4(+) + CO2

Direction not assertedBalancedRhea 27485

2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate

Direction not assertedBalancedRhea 27489

tricetin + S-adenosyl-L-methionine = 3'-O-methyltricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 27493

3'-O-methyltricetin + S-adenosyl-L-methionine = 3',5'-di-O-methyltricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 27497

3',5'-di-O-methyltricetin + S-adenosyl-L-methionine = 3',4',5'-O-trimethyltricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 27501

cocaine + H2O = ecgonine methyl ester + benzoate + H(+)

Direction not assertedBalancedRhea 27506

enolpyruvoyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = dehydro coenzyme F420-0 + GMP + H(+)

Direction not assertedBalancedRhea 27510

sphinganine 1-phosphate + H2O = sphinganine + phosphate

Left to rightBalancedRhea 27514

sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate

Left to rightBalancedRhea 27518

2,5-dihydroxypyridine + O2 = N-formylmaleamate + H(+)

Direction not assertedBalancedRhea 27522

(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate

Direction not assertedBalancedRhea 27526

(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate

Direction not assertedBalancedRhea 27530

(2E,6E)-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphate

Direction not assertedBalancedRhea 27534

N,N-dimethyl-4-nitrosoaniline + ethanol = 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde

Direction not assertedBalancedRhea 27538

N,N-dimethyl-4-nitrosoaniline + methanol = 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde

Direction not assertedBalancedRhea 27542

anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H2O + H(+)

Direction not assertedBalancedRhea 27546

8 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate

Direction not assertedBalancedRhea 27551

2 isopentenyl diphosphate + (2E,6E,10E)-geranylgeranyl diphosphate = all-trans-hexaprenyl diphosphate + 2 diphosphate

Direction not assertedBalancedRhea 27555

3 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-hexaprenyl diphosphate + 3 diphosphate

Direction not assertedBalancedRhea 27559

7 isopentenyl diphosphate + (2E)-geranyl diphosphate = all-trans-nonaprenyl diphosphate + 7 diphosphate

Direction not assertedBalancedRhea 27563

D-glycero-alpha-D-manno-heptose 7-phosphate + ATP = D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 27570

(3R)-piperidine-3-carboxamide + H2O = (3R)-piperidine-3-carboxylate + NH4(+)

Direction not assertedBalancedRhea 27574

(R)-N-tert-butylpiperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + tert-butylamine

Direction not assertedBalancedRhea 27578

(S)-2-hydroxymethylglutarate = 2-methyleneglutarate + H2O

Direction not assertedBalancedRhea 27582

L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine

Direction not assertedBalancedRhea 27586

(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 27590

5 isopentenyl diphosphate + (2E,6E,10E)-geranylgeranyl diphosphate = all-trans-nonaprenyl diphosphate + 5 diphosphate

Direction not assertedBalancedRhea 27594

(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate = di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate

Direction not assertedBalancedRhea 27602

a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine

Left to rightBalance undeterminableRhea 27606

formate + H(+) = H2 + CO2

Direction not assertedBalancedRhea 27610

(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate = di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate

Direction not assertedBalancedRhea 27614

(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate = di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate

Direction not assertedBalancedRhea 27618

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