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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,901–3,950 of 18,558 reactions from Rhea

delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP
Direction not assertedBalancedRhea 26498
delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose = ternatin C5 + UDP + 2 H(+)
Direction not assertedBalancedRhea 26502
(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+)
Left to rightBalancedRhea 26506
L-prolinamide + H2O = L-proline + NH4(+)
Direction not assertedBalancedRhea 26510
cyclohexan-1,2-dione + H2O = 6-oxohexanoate + H(+)
Direction not assertedBalancedRhea 26514
3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O
Right to leftBalancedRhea 26518
(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O

Direction not assertedBalancedRhea 26522

a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O

Right to leftBalance undeterminableRhea 26526

4-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O

Direction not assertedBalancedRhea 26530

3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 26534

(R)-piperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + NH4(+)

Direction not assertedBalancedRhea 26542

beta-alaninamide + H2O = beta-alanine + NH4(+)

Direction not assertedBalancedRhea 26546

(S)-piperazine-2-carboxamide + H2O = (S)-piperazine-2-carboxylate + NH4(+)

Direction not assertedBalancedRhea 26550

angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine

Left to rightBalancedRhea 26554

(3S)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O

Right to leftBalancedRhea 26558

2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O

Direction not assertedBalancedRhea 26562

hexadecanal + NADP(+) + CoA = hexadecanoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 27270

2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)

Direction not assertedBalancedRhea 27274

2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 27278

2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)

Direction not assertedBalancedRhea 27282

(S)-acetoin + NAD(+) = diacetyl + NADH + H(+)

Direction not assertedBalancedRhea 27286

formate + A + H(+) = AH2 + CO2

Direction not assertedBalancedRhea 27290

oxidized coenzyme F420-(gamma-L-Glu)(n) + D-glucose 6-phosphate + H(+) = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)

Direction not assertedBalance undeterminableRhea 27294

2-formylbenzoate + NAD(+) + H2O = phthalate + NADH + 2 H(+)

Direction not assertedBalancedRhea 27298

7-chloro-L-tryptophan + O2 = 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2

Direction not assertedBalancedRhea 27302

D-proline + A = 1-pyrroline-2-carboxylate + AH2

Direction not assertedBalancedRhea 27306

naphthalene-1,2-diol + O2 = 2-hydroxychromene-2-carboxylate + H(+)

Direction not assertedBalancedRhea 27310

dichlorochromopyrrolate + 4 NADH + 4 O2 + 6 H(+) = dichloroarcyriaflavin A + 2 CO2 + 4 NAD(+) + 6 H2O

Direction not assertedBalancedRhea 27314

3-epi-6-deoxocathasterone + reduced [NADPH--hemoprotein reductase] + O2 = 6-deoxotyphasterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 27321

(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + reduced [NADPH--hemoprotein reductase] + O2 = 3-dehydro-6-deoxoteasterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 27325

urate + NADH + O2 + H(+) = 5-hydroxyisourate + NAD(+) + H2O

Direction not assertedBalancedRhea 27329

6-hydroxynicotinate + NADH + O2 + 2 H(+) = 2,5-dihydroxypyridine + CO2 + NAD(+) + H2O

Direction not assertedBalancedRhea 27333

reduced 2[4Fe-4S]-[ferredoxin] + progesterone + O2 + 2 H(+) = 15beta-hydroxyprogesterone + oxidized 2[4Fe-4S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 27337

AH2 + NH4(+) + O2 = hydroxylamine + A + H2O + H(+)

Direction not assertedBalancedRhea 27341

FMNH2 + O2 = dialurate + 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + H(+)

Direction not assertedBalancedRhea 27345

mycothiol + arsenate = arseno-mycothiol + H2O

Direction not assertedBalancedRhea 27349

4'-demethylrebeccamycin + S-adenosyl-L-methionine = rebeccamycin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 27353

iodide + S-adenosyl-L-methionine = iodomethane + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 27357

chloride + S-adenosyl-L-methionine = chloromethane + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 27361

bromide + S-adenosyl-L-methionine = bromomethane + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 27365

acetoin + NAD(+) + CoA = acetaldehyde + acetyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 27369

(R)-glycerate + ATP = (2R)-2-phosphoglycerate + ADP + H(+)

Direction not assertedBalancedRhea 27377

(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate

Left to rightBalancedRhea 27381

maleamate + H2O = maleate + NH4(+)

Direction not assertedBalancedRhea 27385

(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O = salicylaldehyde + pyruvate

Direction not assertedBalancedRhea 27389

2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = dichlorochromopyrrolate + NH4(+) + 2 H2O + H(+)

Direction not assertedBalancedRhea 27393

4'-demethylrebeccamycin + H2O = dichloroarcyriaflavin A + beta-D-glucose

Direction not assertedBalancedRhea 27397

2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate

Direction not assertedBalancedRhea 27401

a ubiquinone + pyruvate + H2O = a ubiquinol + acetate + CO2

Direction not assertedBalance undeterminableRhea 27405

protoporphyrinogen IX + 3 a menaquinone = protoporphyrin IX + 3 a menaquinol

Direction not assertedBalance undeterminableRhea 27409

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