Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,851–3,900 of 18,558 reactions from Rhea

Co-precorrin-5A + H2O = Co-precorrin-5B + acetaldehyde + H(+)
Direction not assertedBalancedRhea 26281
Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine
Direction not assertedBalancedRhea 26285
cob(II)yrinate + 2 L-glutamine + 2 ATP + 2 H2O = cob(II)yrinate a,c diamide + 2 L-glutamate + 2 ADP + 2 phosphate + 2 H(+)
Direction not assertedBalancedRhea 26289
(1'S,5'S)-averufin + NADPH + O2 = 1'-hydroxyversicolorone + NADP(+) + H2O
Direction not assertedBalancedRhea 26293
[ThiS sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + 2-iminoacetate + 1-deoxy-D-xylulose 5-phosphate = [ThiS sulfur-carrier protein]-C-terminal Gly-Gly + 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 26297
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2
Left to right

Balanced

Rhea 26301

2-aminophenol + O2 = 2-aminomuconate 6-semialdehyde

Direction not assertedBalancedRhea 26305

1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H(+)

Direction not assertedBalancedRhea 26309

2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = L-aspartate 4-semialdehyde + dihydroxyacetone phosphate

Direction not assertedBalancedRhea 26313

2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = 3-amino-4-hydroxybenzoate + phosphate + 2 H2O + H(+)

Direction not assertedBalancedRhea 26317

resorcinol + S-adenosyl-L-methionine = 3-methoxyphenol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 26321

(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine = (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 26325

(8S)-8-amino-7-oxononanoate + L-lysine = (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate

Direction not assertedBalancedRhea 26329

2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)

Left to rightBalance undeterminableRhea 26333

S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

Direction not assertedBalancedRhea 26337

S-methyl-L-methionine + L-selenocysteine = Se-methyl-L-selenocysteine + L-methionine + H(+)

Direction not assertedBalancedRhea 26341

L-galactonate + NADP(+) = aldehydo-D-galacturonate + NADPH + H(+)

Direction not assertedBalancedRhea 26345

beta-L-galactose 1-phosphate + H2O = L-galactose + phosphate

Direction not assertedBalancedRhea 26349

L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)

Direction not assertedBalancedRhea 26361

prostamide F2alpha + [thioredoxin]-disulfide = prostamide H2 + [thioredoxin]-dithiol

Direction not assertedBalance undeterminableRhea 26373

GTP = cyclic pyranopterin phosphate + diphosphate

Direction not assertedBalancedRhea 26377

4-hydroxybutanoate + NADP(+) = succinate semialdehyde + NADPH + H(+)

Direction not assertedBalancedRhea 26381

all-trans-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal

Direction not assertedBalancedRhea 26385

all-trans-beta-carotene + O2 = beta-ionone + all-trans-10'-apo-beta-carotenal

Left to rightBalancedRhea 26389

all-trans-zeaxanthin + 2 O2 = 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + 2 (3R)-hydroxy-beta-ionone

Left to rightBalancedRhea 26393

all-trans-zeaxanthin + 2 O2 = crocetin dialdehyde + 2 3beta-hydroxy-beta-cyclocitral

Direction not assertedBalancedRhea 26397

all-trans-10'-apo-beta-carotenal + O2 = (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone

Direction not assertedBalancedRhea 26401

aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) = pyridoxal 5'-phosphate + phosphate + 4 H2O + H(+)

Direction not assertedBalancedRhea 26405

N-acetyl-D-muramate 6-phosphate + H2O = N-acetyl-D-glucosamine 6-phosphate + (R)-lactate

Direction not assertedBalancedRhea 26410

a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2

Direction not assertedBalance undeterminableRhea 26414

(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal

Direction not assertedBalancedRhea 26418

thyroxine + 3'-phosphoadenylyl sulfate = thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 26422

UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)

Left to rightBalancedRhea 26426

(+)-copalyl diphosphate + H2O = phyllocladan-16alpha-ol + diphosphate

Direction not assertedBalancedRhea 26430

indole + L-serine = L-tryptophan + H2O

Direction not assertedBalancedRhea 26434

3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + NADPH + H(+)

Direction not assertedBalancedRhea 26438

ethanol + a ubiquinone = a ubiquinol + acetaldehyde

Direction not assertedBalance undeterminableRhea 26442

3-oxopropanoate + NADP(+) + CoA = malonyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 26446

succinate semialdehyde + NADP(+) + CoA = succinyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 26450

propanoyl-CoA + NADP(+) = acryloyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 26454

ethylnitronate + FMNH2 + O2 = acetaldehyde + FMN + nitrite + H2O + 2 H(+)

Direction not assertedBalancedRhea 26458

6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine = 2-methoxy-5-methyl-6-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 26462

a 2-demethylmenaquinone + S-adenosyl-L-methionine = a menaquinone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 26466

16-hydroxyhexadecanoate + (E)-feruloyl-CoA = 16-feruloyloxyhexadecanoate + CoA

Direction not assertedBalancedRhea 26470

beta-D-galactosyl-(1->4)-L-rhamnose + phosphate = alpha-D-galactose 1-phosphate + L-rhamnopyranose

Direction not assertedBalancedRhea 26474

an all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate

Direction not assertedBalance undeterminableRhea 26478

adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate

Direction not assertedBalancedRhea 26482

O-phospho-L-serine + sulfite + H(+) = L-cysteate + phosphate

Direction not assertedBalancedRhea 26486

a secondary nitroalkane + O2 + H2O = a ketone + nitrite + H2O2 + H(+)

Direction not assertedBalance undeterminableRhea 26490

L-tryptophan + FADH2 + chloride + O2 = 7-chloro-L-tryptophan + FAD + 2 H2O

Direction not assertedBalancedRhea 26494

Page 78 of 372