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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,801–3,850 of 18,558 reactions from Rhea

Co(I)-[methylamine-specific corrinoid protein] + methylamine + H(+) = methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)
Direction not assertedBalance undeterminableRhea 26059
hygromycin B + ATP = 4-O-phosphohygromycin B + ADP + H(+)
Direction not assertedBalancedRhea 26064
3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O = phosphinomethylmalate + CoA + H(+)
Direction not assertedBalancedRhea 26068
UDP-alpha-D-glucuronate + H2O = D-glucuronate + UDP + H(+)
Direction not assertedBalancedRhea 26073
methanesulfonate + NADH + O2 = sulfite + formaldehyde + NAD(+) + H2O
Direction not assertedBalancedRhea 26077
(2E,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate
Direction not assertedBalancedRhea 26081
(4S)-limonene + NADPH + O2 + H(+) = limonene 1,2-epoxide + NADP(+) + H2O

Direction not assertedBalancedRhea 26085

(4S)-limonene + NADH + O2 + H(+) = limonene 1,2-epoxide + NAD(+) + H2O

Direction not assertedBalancedRhea 26089

(4R)-limonene + NADH + O2 + H(+) = limonene 1,2-epoxide + NAD(+) + H2O

Direction not assertedBalancedRhea 26093

(4R)-limonene + NADPH + O2 + H(+) = limonene 1,2-epoxide + NADP(+) + H2O

Direction not assertedBalancedRhea 26097

(2R)-homocitrate = cis-homoaconitate + H2O

Direction not assertedBalancedRhea 26101

UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O

Direction not assertedBalancedRhea 26111

(2E,6E)-farnesyl diphosphate + H2O = epi-cedrol + diphosphate

Direction not assertedBalancedRhea 26115

(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + 2 reduced [2Fe-2S]-[ferredoxin] + H(+)

Direction not assertedBalance undeterminableRhea 26119

(+)-copalyl diphosphate = isopimara-7,15-diene + diphosphate

Direction not assertedBalancedRhea 26128

2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

Left to rightBalancedRhea 26132

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = ethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate

Left to rightBalancedRhea 26136

2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H2O + H(+) = 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)

Direction not assertedBalancedRhea 26140

(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)

Direction not assertedBalancedRhea 26152

D-mannose + NADP(+) = 2-dehydro-D-glucose + NADPH + H(+)

Direction not assertedBalancedRhea 26156

(S)-2,3-epoxysqualene = thalianol

Direction not assertedBalancedRhea 26160

echinenone + AH2 + O2 = 4'-hydroxyechinenone + A + H2O

Direction not assertedBalancedRhea 26164

3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

Direction not assertedBalancedRhea 26168

1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + CoA + H(+)

Direction not assertedBalancedRhea 26172

1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + L-cysteine + ATP = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 26176

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate

Direction not assertedBalancedRhea 26180

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate

Direction not assertedBalancedRhea 26184

1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP + H(+)

Direction not assertedBalancedRhea 26188

(S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

Direction not assertedBalancedRhea 26193

melamine + H2O = ammeline + NH4(+)

Direction not assertedBalancedRhea 26197

ammeline + H2O + H(+) = ammelide + NH4(+)

Direction not assertedBalancedRhea 26201

4-nitrophenol + NADPH + O2 + H(+) = 4-nitrocatechol + NADP(+) + H2O

Direction not assertedBalancedRhea 26205

L-allo-threonine = acetaldehyde + glycine

Left to rightBalancedRhea 26209

9alpha-copalyl diphosphate + H2O = aphidicolan-16beta-ol + diphosphate

Direction not assertedBalancedRhea 26213

abieta-7,13-diene + reduced [NADPH--hemoprotein reductase] + O2 = abieta-7,13-dien-18-ol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 26217

abieta-7,13-dien-18-ol + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = abieta-7,13-dien-18-oate + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 3 H(+)

Direction not assertedBalance undeterminableRhea 26221

abieta-7,13-dien-18-al + NAD(+) + H2O = abieta-7,13-dien-18-oate + NADH + 2 H(+)

Direction not assertedBalancedRhea 26225

phytyl diphosphate + 3 NADP(+) = geranylgeranyl diphosphate + 3 NADPH + 3 H(+)

Direction not assertedBalancedRhea 26229

(2E,6E,10E)-geranylgeraniol + reduced [NADPH--hemoprotein reductase] + O2 = plaunotol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 26233

(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeraniol + diphosphate

Direction not assertedBalancedRhea 26237

geranylgeranyl diphosphate = elisabethatriene + diphosphate

Direction not assertedBalancedRhea 26241

geranylgeranyl diphosphate = fusicocca-2,10(14)-diene + diphosphate

Direction not assertedBalancedRhea 26245

levopimaradienol + NADPH + O2 + H(+) = levopimaradienal + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 26249

isopimara-7,15-dienol + NADPH + O2 + H(+) = isopimara-7,15-dienal + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 26253

dehydroabietadienol + NADPH + O2 + H(+) = dehydroabietadienal + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 26257

isopimara-7,15-dienal + NADP(+) + H2O = isopimarate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 26261

dehydroabietadienal + NADP(+) + H2O = dehydroabietate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 26265

Co-precorrin-2 + 3 H(+) = precorrin-2 + Co(2+)

Direction not assertedBalancedRhea 26269

Co-precorrin-3 + S-adenosyl-L-methionine = Co-precorrin-4 + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 26273

Co-precorrin-4 + S-adenosyl-L-methionine = Co-precorrin-5A + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 26277

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