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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,551–3,600 of 18,558 reactions from Rhea

calcitetrol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = (1S)-1,25-dihydroxy-24-oxocalciol + 2 oxidized [adrenodoxin] + 2 H2O
Left to rightBalance undeterminableRhea 24972
(1S)-1,25-dihydroxy-24-oxocalciol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = (1S)-1,23,25-trihydroxy-24-oxocalciol + 2 oxidized [adrenodoxin] + H2O
Left to rightBalance undeterminableRhea 24976
3-hydroxy-4-methylanthranilate + ATP + H(+) = 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate
Direction not assertedBalancedRhea 24980
(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 oxidized [adrenodoxin] + 2 H2O
Left to rightBalance undeterminableRhea 24984
(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 reduced [adrenodoxin] + O2 + H(+) = calcitroate + 2 oxidized [adrenodoxin] + H2O
Left to rightBalance undeterminableRhea 24988
L-phenylalanine + reduced [NADPH--hemoprotein reductase] + O2 = N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

? Direction not asserted

Balance undeterminable

Rhea 24992

N-hydroxy-L-phenylalanine + reduced [NADPH--hemoprotein reductase] + O2 = N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 24996

N,N-dihydroxy-L-phenylalanine + H(+) = (E)-phenylacetaldehyde oxime + CO2 + H2O

Direction not assertedBalancedRhea 25000

L-tryptophan + reduced [NADPH--hemoprotein reductase] + O2 = N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 25005

N-hydroxy-L-tryptophan + reduced [NADPH--hemoprotein reductase] + O2 = N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 25009

N,N-dihydroxy-L-tryptophan + H(+) = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O

Direction not assertedBalancedRhea 25013

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate

Left to rightBalance undeterminableRhea 25017

riboflavin + CTP = CDP + FMN + H(+)

Direction not assertedBalancedRhea 25021

S-methyl-5'-thioadenosine + H2O + H(+) = S-methyl-5'-thioinosine + NH4(+)

Direction not assertedBalancedRhea 25025

ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate

Direction not assertedBalancedRhea 25029

all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)

Right to leftBalancedRhea 25033

L-seryl-tRNA(Sec) + ATP = O-phospho-L-seryl-tRNA(Sec) + ADP

Direction not assertedBalancedRhea 25037

O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H2O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate

Direction not assertedBalancedRhea 25041

(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)

Direction not assertedBalancedRhea 25046

(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)

Direction not assertedBalancedRhea 25054

(E)-cinnamate + NADH + O2 + H(+) = (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)

Direction not assertedBalancedRhea 25058

3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + NADH + H(+)

Direction not assertedBalancedRhea 25062

(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H(+)

Direction not assertedBalancedRhea 25066

3-hydroxybenzoate + ATP + CoA = 3-hydroxybenzoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 25070

(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O

Direction not assertedBalancedRhea 25074

(2S)-2-isopropyl-3-oxosuccinate + H(+) = 4-methyl-2-oxopentanoate + CO2

Direction not assertedBalancedRhea 25078

dCMP + ATP = dCDP + ADP

Direction not assertedBalancedRhea 25094

UDP + ATP = UTP + ADP

Left to rightBalancedRhea 25098

pyridoxamine + ATP = pyridoxamine 5'-phosphate + ADP + H(+)

Left to rightBalancedRhea 25104

pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+)

Left to rightBalancedRhea 25108

pyridoxine 5'-phosphate + H2O = pyridoxine + phosphate

Left to rightBalancedRhea 25112

L-lysine + NAD(+) + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 25117

(S)-2-amino-6-oxohexanoate = L-1-piperideine-6-carboxylate + H2O + H(+)

Direction not assertedBalancedRhea 25121

pyridoxamine + phosphate = pyridoxamine 5'-phosphate + H2O

Right to leftBalancedRhea 25135

3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

Direction not assertedBalancedRhea 25143

(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde = quinolinate + H2O + H(+)

Direction not assertedBalancedRhea 25147

L-phenylalanine + 2-oxoglutarate = 3-phenylpyruvate + L-glutamate

Direction not assertedBalancedRhea 25152

(R)-4'-phosphopantothenate + L-cysteine + ATP = N-[(R)-4-phosphopantothenoyl]-L-cysteine + AMP + diphosphate + H(+)

Left to rightBalancedRhea 25156

L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

ReversibleBalancedRhea 25160

butanoyl-CoA + A = (2E)-butenoyl-CoA + AH2

Direction not assertedBalancedRhea 25164

6-hydroxyhexan-6-olide = 6-oxohexanoate + H(+)

Direction not assertedBalancedRhea 25168

N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamine

Left to rightBalancedRhea 25173

4-methyl-2-oxopentanoate + NAD(+) + CoA = 3-methylbutanoyl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 25177

putrescine + acetyl-CoA = N-acetylputrescine + CoA + H(+)

Direction not assertedBalancedRhea 25181

1,2-dichloroethane + H2O = 2-chloroethanol + chloride + H(+)

Direction not assertedBalancedRhea 25185

chloroacetate + H2O = glycolate + chloride + H(+)

Direction not assertedBalancedRhea 25189

(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + NADH + H(+)

Direction not assertedBalancedRhea 25193

5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate

Direction not assertedBalancedRhea 25197

D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose 6-phosphate

Direction not assertedBalancedRhea 25201

UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine + H2O = UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + acetate

Direction not assertedBalancedRhea 25209

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