Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,501–3,550 of 18,558 reactions from Rhea

L-methionyl(44)-[F-actin] + NADPH + O2 + H(+) = L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+) + H2O
Direction not assertedBalance undeterminableRhea 24722
N-demethylindolmycin + S-adenosyl-L-methionine = indolmycin + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 24726
anthranilate + H(+) = aniline + CO2
Direction not assertedBalancedRhea 24730
4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde
Direction not assertedBalancedRhea 24734
(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H(+)
Direction not assertedBalancedRhea 24738
L-methionine = 2-aminobut-2-enoate + methanethiol
Direction not assertedBalancedRhea 24746
primary fluorescent chlorophyll catabolite + 2 oxidized [2Fe-2S]-[ferredoxin] = red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin] + 3 H(+)

Direction not assertedBalance undeterminableRhea 24752

L-dopa + NADH + H(+) = 3-(3,4-dihydroxyphenyl)propanoate + NH4(+) + NAD(+)

Direction not assertedBalancedRhea 24760

UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate

Direction not assertedBalancedRhea 24764

7(1)-hydroxychlorophyllide a + NAD(+) = chlorophyllide b + NADH + H(+)

Direction not assertedBalancedRhea 24768

7(1)-hydroxychlorophyllide a + NADP(+) = chlorophyllide b + NADPH + H(+)

Direction not assertedBalancedRhea 24772

pheophorbide a + H2O = C-13(2)-carboxypyropheophorbide a + methanol

Direction not assertedBalancedRhea 24776

C-13(2)-carboxypyropheophorbide a + H(+) = pyropheophorbide a + CO2

Direction not assertedBalancedRhea 24780

3-(3-hydroxyphenyl)propanoate + NADH + O2 + H(+) = 3-(2,3-dihydroxyphenyl)propanoate + NAD(+) + H2O

Direction not assertedBalancedRhea 24785

(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + succinate + H(+)

Direction not assertedBalancedRhea 24789

5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)

Direction not assertedBalancedRhea 24793

(S)-2,3,4,5-tetrahydrodipicolinate + H2O + H(+) = (S)-2-amino-6-oxoheptanedioate

Direction not assertedBalancedRhea 24797

L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

Left to rightBalancedRhea 24801

(2S)-2-acetolactate + thiamine diphosphate = 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate

Direction not assertedBalancedRhea 24805

(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O

Direction not assertedBalancedRhea 24809

L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate

Left to rightBalancedRhea 24813

dimethylallyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 24825

N(1)-(5-phospho-beta-D-ribosyl)glycinamide + formate + ATP = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 24829

5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + formate + ATP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate

Direction not assertedBalancedRhea 24836

5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + CO + 5'-deoxyadenosine + formate + L-methionine + 3 H(+)

Direction not assertedBalancedRhea 24840

cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O = 2 isomaltose

Direction not assertedBalancedRhea 24844

3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O

Direction not assertedBalancedRhea 24848

pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose = pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 24861

(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 = 4-O-deacetyl-16-O-demethylvindoline + succinate + CO2

Direction not assertedBalancedRhea 24865

5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine

Direction not assertedBalancedRhea 24869

O-phospho-D-serine + H2O = D-serine + phosphate

Left to rightBalancedRhea 24873

L-sorbopyranose + A = 1-dehydro-L-sorbose + AH2

Direction not assertedBalancedRhea 24878

(S)-1-pyrroline-5-carboxylate + NADP(+) + 2 H2O = L-glutamate + NADPH + H(+)

Direction not assertedBalancedRhea 24882

5-hydroxyxanthotoxin + S-adenosyl-L-methionine = isopimpinellin + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 24894

2 GTP = 3',3'-c-di-GMP + 2 diphosphate

Direction not assertedBalancedRhea 24898

3',3'-c-di-GMP + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)

Direction not assertedBalancedRhea 24902

L-tyrosine = (E)-4-coumarate + NH4(+)

Direction not assertedBalancedRhea 24906

L,L-cystathionine = 2-aminobut-2-enoate + L-cysteine

Direction not assertedBalancedRhea 24910

L-homoserine = 2-aminobut-2-enoate + H2O

Direction not assertedBalancedRhea 24919

L-homoserine = 2-oxobutanoate + NH4(+)

Left to rightBalancedRhea 24923

L-cystine + H2O = S-sulfanyl-L-cysteine + pyruvate + NH4(+)

Direction not assertedBalancedRhea 24927

L-cysteine + H2O = hydrogen sulfide + pyruvate + NH4(+) + H(+)

Left to rightBalancedRhea 24931

imidazol-4-one + H2O = N-formimidoylglycine

Direction not assertedBalancedRhea 24935

(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + NADP(+) + 2 H2O = (4S)-4-hydroxy-L-glutamate + NADPH + H(+)

Direction not assertedBalancedRhea 24943

3-hydroxy-3-methylglutarate + malonyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + malonate

Direction not assertedBalancedRhea 24948

1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = N-acetyl-D-muramate 6-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 24952

N-acetyl-beta-D-muramate 6-phosphate + H2O = N-acetyl-beta-D-glucosamine 6-phosphate + (R)-lactate

Direction not assertedBalancedRhea 24956

apo-[aequorin] + coelenterazine + 3 Ca(2+) + O2 = excited state-[aequorin] + CO2

Direction not assertedBalance undeterminableRhea 24960

calcitriol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = calcitetrol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 24964

calcidiol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = secalciferol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 24968

Page 71 of 372