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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

301–350 of 18,558 reactions from Rhea

a (2R)-2-hydroxycarboxylate + a quinone = a 2-oxocarboxylate + a quinol
Direction not assertedBalance undeterminableRhea 11272
4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O
Direction not assertedBalancedRhea 11276
dCMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O = 5-hydroxymethyl-dCMP + (6S)-5,6,7,8-tetrahydrofolate
Direction not assertedBalancedRhea 11280
hydroxymalonate + NAD(+) = oxomalonate + NADH + H(+)
Direction not assertedBalancedRhea 11284
dihydromacarpine + O2 + H(+) = macarpine + H2O2
Direction not assertedBalancedRhea 11288
rifamycin B + O2 + 2 H(+) = rifamycin O + H2O2
Direction not assertedBalancedRhea 11292
2,5-dioxopentanoate + NADP(+) + H2O = 2-oxoglutarate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 11296

1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H(+)

Direction not assertedBalancedRhea 11300

(S)-ureidoglycolate = urea + glyoxylate

Direction not assertedBalancedRhea 11304

hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)

Left to rightBalancedRhea 11308

atrazine + H2O = hydroxyatrazine + chloride + H(+)

Direction not assertedBalancedRhea 11312

an aliphatic aldoxime = a nitrile + H2O

Direction not assertedBalance undeterminableRhea 11316

UDP-beta-L-arabinopyranose = UDP-alpha-D-xylose

Direction not assertedBalancedRhea 11320

isopentenyl diphosphate + dimethylallyl diphosphate = neryl diphosphate + diphosphate

Direction not assertedBalancedRhea 11328

RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate

Left to rightBalance undeterminableRhea 11332

(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = deacetoxyvindoline + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 11336

5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO2

Direction not assertedBalancedRhea 11340

an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate

Direction not assertedBalance undeterminableRhea 11344

arsenite(in) + ATP + H2O = arsenite(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 11348

acetate + ATP = acetyl phosphate + ADP

Direction not assertedBalancedRhea 11352

A + NADH + H(+) = AH2 + NAD(+)

Direction not assertedBalancedRhea 11356

pyruvate + ATP + H2O = phosphoenolpyruvate + AMP + phosphate + 2 H(+)

Direction not assertedBalancedRhea 11364

L-aspartate + NH4(+) + ATP = L-asparagine + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 11372

(19E)-geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + NADPH

Direction not assertedBalancedRhea 11376

[2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2

Direction not assertedBalancedRhea 11380

(S)-2-hydroxyoctadecanoate + NAD(+) = 2-oxooctadecanoate + NADH + H(+)

Direction not assertedBalancedRhea 11384

an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH + H(+)

ReversibleBalance undeterminableRhea 11388

1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate

Left to rightBalancedRhea 11392

5-methyldeoxycytidine 5'-phosphate + ATP = 5-methyldeoxycytidine diphosphate + ADP

Direction not assertedBalancedRhea 11396

sordaricin + GDP-6-deoxy-alpha-D-altrose = 4'-O-demethylsordarin + GDP + H(+)

Direction not assertedBalancedRhea 11400

UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate

Direction not assertedBalancedRhea 11404

riboflavin + H2O + H(+) = lumichrome + ribitol

Direction not assertedBalancedRhea 11408

6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)

Direction not assertedBalancedRhea 11412

2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose

Direction not assertedBalancedRhea 11416

senecionine + NADPH + O2 = senecionine N-oxide + NADP(+) + H2O

Direction not assertedBalancedRhea 11420

L-threonyl-[myosin heavy-chain] + ATP = O-phospho-L-threonyl-[myosin heavy-chain] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 11424

beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2

Direction not assertedBalancedRhea 11428

vitexin 2''-O-beta-L-rhamnoside + S-adenosyl-L-methionine = 7-O-methylvitexin 2''-O-beta-L-rhamnoside + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 11432

4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)

Left to rightBalance undeterminableTransportRhea 11436

2,3,5,6-tetrachlorophenol + NADPH + O2 = 2,3,5,6-tetrachlorohydroquinone + NADP(+) + H2O

Direction not assertedBalancedRhea 11440

4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + sulfate + H(+)

Direction not assertedBalancedRhea 11444

pregnan-21-ol + NAD(+) = pregnan-21-al + NADH + H(+)

Direction not assertedBalancedRhea 11448

7-deoxyloganin + reduced [NADPH--hemoprotein reductase] + O2 = loganin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 11452

N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 11456

D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)

Direction not assertedBalancedRhea 11460

L,L-homocystine + 2 glutathione = 2 L-homocysteine + glutathione disulfide

Direction not assertedBalancedRhea 11464

(S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine

Direction not assertedBalancedRhea 11468

an N-methyl-L-amino acid + O2 + H2O = an L-alpha-amino acid + formaldehyde + H2O2

Direction not assertedBalance undeterminableRhea 11472

glycerol 1-phosphate + H2O = glycerol + phosphate

Direction not assertedBalancedRhea 11476

3-hydroxybenzoate + NADPH + O2 + H(+) = 3,4-dihydroxybenzoate + NADP(+) + H2O

Direction not assertedBalancedRhea 11480

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