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Subsystem: Drug metabolism Remove
301–350 of 572 reactions in Drug metabolism
6'-beta-hydroxy-lovastatin-acid form[c] = 3'-hydroxy-iso-delta-4',5'-hydroxy acid form of lovastatin[c]
Left to rightBalancedHuman-GEM MAR12753
ATP[c] + H2O[c] + 3'-hydroxy-iso-delta-4',5'-hydroxy acid form of lovastatin[c] = ADP[c] + H+[c] + Pi[c] + 3'-hydroxy-iso-delta-4',5'-hydroxy acid form of lovastatin[e]
Left to rightBalancedTransportHuman-GEM MAR12754
Losartan-E3174/ losartan-M6[e] = Losartan-E3174/ losartan-M6[c]
ReversibleBalancedTransportHuman-GEM MAR12755
O2[r] + Losartan[r] = H+[r] + H2O[r] + Losartan-E3174/ losartan-M6[r]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12756
chloride[c] + Losartan-E3174/ losartan-M6[e] = chloride[e] + Losartan-E3174/ losartan-M6[c]
UDP-glucuronate[r] + Losartan[r] = UDP[r] + Losartan-N1-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR12758
Losartan-N1-glucuronide[c] = Losartan-N1-glucuronide[e]
ReversibleBalancedTransportHuman-GEM MAR12759
ATP[c] + H2O[c] + Losartan[c] = ADP[c] + H+[c] + Pi[c] + Losartan[e]
Left to rightBalancedTransportEC 7.6.2.2Human-GEM MAR12760
H+[r] + NADPH[r] + O2[r] + Losartan[r] = H2O[r] + NADP+[r] + Losartan-M1[r]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12761
Losartan-M1[c] = Losartan-M1[e]
ReversibleBalancedTransportHuman-GEM MAR12762
H+[r] + NADPH[r] + O2[r] + Losartan[r] = H2O[r] + NADP+[r] + Losartan-M2[r]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12763
Losartan-M2[c] = Losartan-M2[e]
ReversibleBalancedTransportHuman-GEM MAR12764
UDP-glucuronate[r] + Losartan-E3174/ losartan-M6[r] = UDP[r] + Losartan-M4 (glucuronide derivative)[r]
Left to rightBalancedHuman-GEM MAR12765
Losartan-M4 (glucuronide derivative)[c] = Losartan-M4 (glucuronide derivative)[e]
ReversibleBalancedTransportHuman-GEM MAR12766
H+[r] + NADPH[r] + O2[r] + Losartan[r] = H2O[r] + NADP+[r] + Losartan-M5[r]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12767
Losartan-M5[c] = Losartan-M5[e]
ReversibleBalancedTransportHuman-GEM MAR12768
Losartan-N2-glucuronide / Losartan-M7[e] = Losartan-N2-glucuronide / Losartan-M7[c]
ReversibleBalancedTransportHuman-GEM MAR12769
UDP-glucuronate[r] + Losartan[r] = UDP[r] + Losartan-N2-glucuronide / Losartan-M7[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR12770
chloride[c] + Losartan-N2-glucuronide / Losartan-M7[e] = chloride[e] + Losartan-N2-glucuronide / Losartan-M7[c]
ReversibleBalancedTransportHuman-GEM MAR12771
chloride[c] + Losartan[e] = chloride[e] + Losartan[c]
ReversibleBalancedTransportHuman-GEM MAR12772
Losartan[e] = Losartan[c]
ReversibleBalancedTransportHuman-GEM MAR12773
ATP[c] + lovastatin-hydroxyacid form[c] = AMP[c] + PPi[c] + lovastatin lactone form[c]
Left to rightBalancedHuman-GEM MAR12774
H2O[c] + lovastatin lactone form[c] = H+[c] + lovastatin-hydroxyacid form[c]
Left to rightBalancedEC 3.1.1.2Human-GEM MAR12775
ATP[c] + H2O[c] + lovastatin-hydroxyacid form[c] = ADP[c] + H+[c] + Pi[c] + lovastatin-hydroxyacid form[e]
Left to rightBalancedTransportEC 7.6.2.2Human-GEM MAR12776
H+[r] + NADPH[r] + O2[r] + lovastatin-hydroxyacid form[r] = H2O[r] + NADP+[r] + 6'-beta-hydroxy-lovastatin-acid form[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12777
H+[r] + NADPH[r] + O2[r] + lovastatin-hydroxyacid form[r] = 2 H2O[r] + NADP+[r] + 6'-exomethylene-lovastatin-acid form[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12778
H+[r] + NADPH[r] + O2[r] + lovastatin lactone form[r] = H2O[r] + NADP+[r] + 3''-hydroxy-lovastatin lactone form[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12779
H+[r] + NADPH[r] + O2[r] + lovastatin lactone form[r] = H2O[r] + NADP+[r] + 6'-beta-hydroxy-lovastatin lactone form[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12780
H+[r] + NADPH[r] + O2[r] + lovastatin lactone form[r] = 2 H2O[r] + NADP+[r] + 6'-exomethylene-lovastatin lactone form[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12781
ATP[c] + H2O[c] + lovastatin lactone form[c] = ADP[c] + H+[c] + Pi[c] + lovastatin lactone form[e]
Left to rightBalancedTransportEC 7.6.2.2Human-GEM MAR12782
lovastatin lactone form[e] = lovastatin lactone form[c]
ReversibleBalancedTransportHuman-GEM MAR12783
Midazolam-glucuronide[c] = Midazolam-glucuronide[e]
ReversibleBalancedTransportHuman-GEM MAR12784
Midazolam[e] = Midazolam[c]
ReversibleBalancedTransportHuman-GEM MAR12785
ATP[c] + H2O[c] + Midazolam[c] = ADP[c] + H+[c] + Pi[c] + Midazolam[e]
Left to rightBalancedTransportEC 7.6.2.2Human-GEM MAR12786
ATP[c] + H2O[c] + acetaminophen-mercapturate-conjugate/N-acetyl-cysteine-acetaminophen[c] = ADP[c] + H+[c] + Pi[c] + acetaminophen-mercapturate-conjugate/N-acetyl-cysteine-acetaminophen[e]
Left to rightBalancedTransportHuman-GEM MAR12787
ATP[c] + H2O[c] + acetaminophen-mercapturate-conjugate/N-acetyl-cysteine-acetaminophen[e] = ADP[c] + H+[c] + Pi[c] + acetaminophen-mercapturate-conjugate/N-acetyl-cysteine-acetaminophen[c]
Left to rightBalancedTransportHuman-GEM MAR12788
ATP[c] + H2O[c] + Methyl-hydroxy-gliclazide[c] = ADP[c] + H+[c] + Pi[c] + Methyl-hydroxy-gliclazide[e]
Left to rightBalancedTransportHuman-GEM MAR12789
H+[r] + NADPH[r] + O2[r] + Gliclazide[r] = H2O[r] + NADP+[r] + Methyl-hydroxy-gliclazide[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12790
Methyl-hydroxy-gliclazide[c] = Methyl-hydroxy-gliclazide[e]
ReversibleBalancedTransportHuman-GEM MAR12791
H+[r] + NADPH[r] + O2[r] + 2 SAH[r] + rosuvastatin[r] = H2O2[r] + NADP+[r] + 2 SAM[r] + N-desmethyl-rosuvastatin[r]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12792
ATP[c] + H2O[c] + N-desmethyl-rosuvastatin[c] = ADP[c] + H+[c] + Pi[c] + N-desmethyl-rosuvastatin[e]
Left to rightBalancedTransportEC 7.6.2.2Human-GEM MAR12793
H+[r] + NADPH[r] + O2[r] + acid metabolite of nifedipine[r] = H2O[r] + NADP+[r] + hydroxy metabolite of nifedipine[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12794
acid metabolite of nifedipine[c] = acid metabolite of nifedipine[e]
ReversibleBalancedTransportHuman-GEM MAR12795
SAH[r] + Nitropyridine metabolite of nifedipine[r] = SAM[r] + acid metabolite of nifedipine[r]
Left to rightBalancedHuman-GEM MAR12796
H+[c] + hydroxy metabolite of nifedipine[c] = H2O[c] + lactone form of nifedipine[c]
ReversibleBalancedHuman-GEM MAR12797
lactone form of nifedipine[c] = lactone form of nifedipine[e]
ReversibleBalancedTransportHuman-GEM MAR12798
Nitropyridine metabolite of nifedipine[c] = Nitropyridine metabolite of nifedipine[e]
ReversibleBalancedTransportHuman-GEM MAR12799
hydroxy metabolite of nifedipine[c] = hydroxy metabolite of nifedipine[e]
ReversibleBalancedTransportHuman-GEM MAR12800
NADP+[c] + nifedipine[c] = H+[c] + NADPH[c] + Nitropyridine metabolite of nifedipine[c]
Left to rightBalancedHuman-GEM MAR12801
oxypurinol[c] + udp-ribose[c] = H+[c] + UDP[c] + oxypurinol-1-riboside[c]
Left to rightBalancedHuman-GEM MAR12802