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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Interactions
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Chemistry

Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,301–3,350 of 18,558 reactions from Rhea

3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)
Direction not assertedBalancedRhea 23840
sedoheptulose + ATP = D-sedoheptulose 7-phosphate + ADP + H(+)
Direction not assertedBalancedRhea 23844
catechol + O2 = cis,cis-muconate + 2 H(+)
Direction not assertedBalancedRhea 23852
Hg + NADP(+) + H(+) = Hg(2+) + NADPH
Direction not assertedBalancedRhea 23856
deacetylcephalosporin C + acetyl-CoA = cephalosporin C + CoA
Direction not assertedBalancedRhea 23860
4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP
Direction not assertedBalancedRhea 23864
(1-hydroxycyclohexan-1-yl)acetyl-CoA = cyclohexanone + acetyl-CoA

Direction not assertedBalancedRhea 23868

(R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 23872

protoaphin aglucone = xanthoaphin + H2O

Direction not assertedBalancedRhea 23876

L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate

Direction not assertedBalance undeterminableRhea 23880

nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine

Left to rightBalancedRhea 23884

[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + L-arginine + ATP = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 23888

3-nitropropanoate + NADP(+) = 3-nitroacrylate + NADPH + H(+)

Direction not assertedBalancedRhea 23892

5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate

Direction not assertedBalancedRhea 23896

cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin

Left to rightBalancedRhea 23900

an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]

ReversibleBalance undeterminableRhea 23904

2 methylcob(III)alamin-[methionine synthase] + 2 S-adenosyl-L-homocysteine + NADP(+) + H(+) = 2 cob(II)alamin-[methionine synthase] + 2 S-adenosyl-L-methionine + NADPH

Right to leftBalance undeterminableRhea 23908

UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2

Left to rightBalancedRhea 23916

(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate

Direction not assertedBalancedRhea 23920

pppGp(2'-5')A = 2',3'-cGAMP + diphosphate

Left to rightBalancedRhea 23924

N(8)-acetylspermidine + H2O = spermidine + acetate

Direction not assertedBalancedRhea 23928

an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate

Direction not assertedBalance undeterminableRhea 23932

D-gluconate + NADP(+) = 5-dehydro-D-gluconate + NADPH + H(+)

Direction not assertedBalancedRhea 23936

D-gluconate + NAD(+) = 5-dehydro-D-gluconate + NADH + H(+)

Direction not assertedBalancedRhea 23940

(E)-coniferol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-(E)-coniferol + UDP + H(+)

Direction not assertedBalancedRhea 23944

4-hydroxybutanoate + NAD(+) = succinate semialdehyde + NADH + H(+)

Direction not assertedBalancedRhea 23948

N-(2-phenylethyl)acetamide + H2O = 2-phenylethylamine + acetate

Direction not assertedBalancedRhea 23952

L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 23956

hexadecanoate + 2 H2O2 + H(+) = pentadecanal + CO2 + 3 H2O

Direction not assertedBalancedRhea 23960

(E)-coniferaldehyde + NADP(+) + H2O = (E)-ferulate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 23964

(E)-coniferaldehyde + NAD(+) + H2O = (E)-ferulate + NADH + 2 H(+)

Direction not assertedBalancedRhea 23968

(2E)-glutaconyl-CoA + Na(+)(in) + H(+) = (2E)-butenoyl-CoA + Na(+)(out) + CO2

Direction not assertedBalancedTransportRhea 23972

a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 23976

cyclomaltodextrin + H2O = linear maltodextrin

Direction not assertedBalance undeterminableRhea 23980

cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+)

Right to leftBalancedRhea 23984

(2S,6S)-2,6-diaminopimelate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H2O + H(+)

Direction not assertedBalancedRhea 23988

a 1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA

Direction not assertedBalance undeterminableRhea 23992

a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)

Left to rightBalance undeterminableRhea 23996

a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA

Direction not assertedBalance undeterminableRhea 24000

butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 24004

hypotaurocyamine + ATP = N(omega)-phosphohypotaurocyamine + ADP + H(+)

Direction not assertedBalancedRhea 24008

gamma-tocopherol + S-adenosyl-L-methionine = (+)-alpha-tocopherol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 24012

16-epivellosimine + acetyl-CoA = vinorine + CoA

Direction not assertedBalancedRhea 24016

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine

ReversibleBalancedRhea 24020

(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine

Direction not assertedBalancedRhea 24024

4-(trimethylamino)butanoate + 2-oxoglutarate + O2 = carnitine + succinate + CO2

Direction not assertedBalancedRhea 24028

sucrose = 6-O-alpha-D-glucopyranosyl-D-fructose

Direction not assertedBalancedRhea 24032

a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP

Direction not assertedBalance undeterminableRhea 24036

2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)

Direction not assertedBalance undeterminableRhea 24040

3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)

Direction not assertedBalancedRhea 24044

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