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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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Reference

Evidence

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Outcomes
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Interactions
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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,251–3,300 of 18,558 reactions from Rhea

a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)
Left to rightBalance undeterminableRhea 23628
D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH
Left to rightBalancedRhea 23632
1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = ethene + L-dehydroascorbate + hydrogen cyanide + CO2 + 2 H2O
Direction not assertedBalancedRhea 23640
lithocholate + reduced [NADPH--hemoprotein reductase] + O2 = hyodeoxycholate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 23644
dTDP-6-deoxy-beta-L-talose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + NADPH + H(+)
Direction not assertedBalancedRhea 23648
N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)
Direction not asserted

Balance undeterminable

Rhea 23652

2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+)

Direction not assertedBalancedRhea 23656

4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate

Direction not assertedBalancedRhea 23660

a (2R)-2-hydroxycarboxylate + A = a 2-oxocarboxylate + AH2

Direction not assertedBalance undeterminableRhea 23664

apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + biotin + ATP = holo-[methylmalonyl-CoA:pyruvate carboxytransferase] + AMP + diphosphate + H(+)

Left to rightBalance undeterminableRhea 23668

L-quinate + a quinone = 3-dehydroquinate + a quinol

Direction not assertedBalance undeterminableRhea 23672

UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6-diaminopimelate + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 23676

a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+)

Left to rightBalance undeterminableRhea 23680

(S)-cis-N-methylcanadine + reduced [NADPH--hemoprotein reductase] + O2 = allocryptopine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 23684

adenine + H2O + H(+) = hypoxanthine + NH4(+)

Direction not assertedBalancedRhea 23688

(R)-malate = maleate + H2O

Direction not assertedBalancedRhea 23692

myo-inositol + O2 = D-glucuronate + H2O + H(+)

Direction not assertedBalancedRhea 23696

(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)

Direction not assertedBalancedRhea 23700

GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)

Direction not assertedBalancedRhea 23704

[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)

Direction not assertedBalance undeterminableRhea 23708

pregnan-21-ol + NADP(+) = pregnan-21-al + NADPH + H(+)

Direction not assertedBalancedRhea 23712

(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA

Left to rightBalancedRhea 23716

propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)

Left to rightBalancedRhea 23720

pyridoxal + O2 + H2O = 4-pyridoxate + H2O2 + H(+)

Direction not assertedBalancedRhea 23724

(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

Left to rightBalancedRhea 23728

(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + CO2 + phosphate

Direction not assertedBalancedRhea 23732

5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)

Direction not assertedBalancedRhea 23736

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

Direction not assertedBalancedRhea 23744

GTP + ATP = pppGp(2'-5')A + diphosphate

Left to rightBalancedRhea 23748

all-trans-undecaprenol + ATP = all-trans-undecaprenyl phosphate + ADP + H(+)

Direction not assertedBalancedRhea 23752

D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)

Direction not assertedBalancedRhea 23756

oxidized coenzyme F420-(gamma-L-Glu)(n) + H2 + H(+) = reduced coenzyme F420-(gamma-L-Glu)(n)

Direction not assertedBalance undeterminableRhea 23760

L-serine + diphosphate = O-phospho-L-serine + phosphate + H(+)

Direction not assertedBalancedRhea 23764

sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)

Left to rightBalance undeterminableRhea 23768

(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + NADH + H(+)

Direction not assertedBalancedRhea 23772

L-aspartate + ATP = 4-phospho-L-aspartate + ADP

Direction not assertedBalancedRhea 23776

propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)

Direction not assertedBalancedRhea 23780

L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

Direction not assertedBalance undeterminableRhea 23784

holo-[citrate lyase ACP] + acetate + ATP = acetyl-[citrate lyase ACP] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 23788

17-O-acetylnorajmaline + H2O = norajmaline + acetate + H(+)

Direction not assertedBalancedRhea 23796

L-methionine + H2O = methanethiol + 2-oxobutanoate + NH4(+)

Direction not assertedBalancedRhea 23800

N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate

Direction not assertedBalancedRhea 23804

(S)-scoulerine + S-adenosyl-L-methionine = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 23808

(+)-neomenthol + NADP(+) = (1R,4S)-menthone + NADPH + H(+)

Direction not assertedBalancedRhea 23812

putrescine + 2-oxoglutarate = 4-aminobutanal + L-glutamate

Direction not assertedBalancedRhea 23816

GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O

Left to rightBalancedRhea 23820

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + NADH + H(+)

Direction not assertedBalancedRhea 23824

2-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + NADPH + H(+)

Direction not assertedBalancedRhea 23828

an N-acyl-D-mannosamine + ATP = an N-acyl-D-mannosamine 6-phosphate + ADP + H(+)

Left to rightBalance undeterminableRhea 23832

D-methionine + pyruvate = 4-methylsulfanyl-2-oxobutanoate + L-alanine

Direction not assertedBalancedRhea 23836

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