Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,151–3,200 of 18,558 reactions from Rhea

4-chlorobenzoate + ATP + CoA = 4-chlorobenzoyl-CoA + AMP + diphosphate
Direction not assertedBalancedRhea 23220
trans-zeatin + UDP-alpha-D-glucose = O-beta-D-glucosyl-trans-zeatin + UDP + H(+)
Direction not assertedBalancedRhea 23224
L-lysine + NADPH + O2 = N(6)-hydroxy-L-lysine + NADP(+) + H2O
Direction not assertedBalancedRhea 23228
hydrazine + 4 Fe(III)-[cytochrome c] = N2 + 4 Fe(II)-[cytochrome c] + 4 H(+)
Direction not assertedBalance undeterminableRhea 23232
[protein]-L-glutamate 5-O-methyl ester + H2O = L-glutamyl-[protein] + methanol + H(+)
Direction not assertedBalance undeterminableRhea 23236
(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate = N-formyl-L-glutamate + (6S)-5,6,7,8-tetrahydrofolate + H(+)
Direction not assertedBalancedRhea 23240
S-adenosyl 3-(methylsulfanyl)propylamine + propane-1,3-diamine = norspermidine + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalancedRhea 23244

myo-inositol + S-adenosyl-L-methionine = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 23248

a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol

Direction not assertedBalance undeterminableRhea 23252

adenosylcob(III)yrinate a,c-diamide + 4 L-glutamine + 4 ATP + 4 H2O = adenosylcob(III)yrate + 4 L-glutamate + 4 ADP + 4 phosphate + 4 H(+)

Direction not assertedBalancedRhea 23256

(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)

Left to rightBalancedRhea 23260

(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADP(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADPH + H(+)

Direction not assertedBalancedRhea 23264

guanidinoacetate + H2O = urea + glycine

Direction not assertedBalancedRhea 23268

an N(6)-alkylaminopurine + UDP-alpha-D-glucose = an N(6)-alkylamino-7-beta-D-glucosylpurine + UDP + H(+)

Direction not assertedBalance undeterminableRhea 23272

2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde

Direction not assertedBalancedRhea 23276

cysteamine + acetyl-CoA = S-acetylcysteamine + CoA

Direction not assertedBalancedRhea 23280

isopentenyl diphosphate = dimethylallyl diphosphate

Direction not assertedBalancedRhea 23284

acetaldehyde + NAD(+) + CoA = acetyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 23288

L-lombricine + ATP = N-phospho-L-lombricine + ADP + H(+)

Direction not assertedBalancedRhea 23292

aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

Direction not assertedBalancedRhea 23296

isopentenyl diphosphate + (2E)-geranyl diphosphate = (2Z,6E)-farnesyl diphosphate + diphosphate

Direction not assertedBalancedRhea 23300

atropine + H2O = tropate + tropine + H(+)

Direction not assertedBalancedRhea 23304

D-glucarate + (E)-sinapoyl-CoA = 2-O-[(E)-sinapoyl]-D-glucarate + CoA

Direction not assertedBalancedRhea 23308

2 sucrose = 1(F)-beta-D-fructosylsucrose + D-glucose

Direction not assertedBalancedRhea 23312

2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + uracil + succinate + CO2

Direction not assertedBalancedRhea 23316

D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H(+)

Direction not assertedBalancedRhea 23320

2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide

Direction not assertedBalance undeterminableRhea 23324

a 9-cis-epoxycarotenoid + O2 = a 12'-apo-carotenal + 2-cis,4-trans-xanthoxin

Direction not assertedBalance undeterminableRhea 23328

(2R)-3-phosphoglycerate + GTP = (2R)-3-phospho-glyceroyl phosphate + GDP

Direction not assertedBalancedRhea 23332

2 iodide + H2O2 + 2 H(+) = diiodine + 2 H2O

Direction not assertedBalancedRhea 23336

3-deoxy-alpha-D-manno-oct-2-ulosonate = D-arabinose + pyruvate

Direction not assertedBalancedRhea 23340

a purine D-ribonucleoside + H2O = a purine nucleobase + D-ribose

Direction not assertedBalance undeterminableRhea 23344

(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2

Direction not assertedBalancedRhea 23348

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

Left to rightBalancedRhea 23352

L-seryl-[rhodopsin] + ATP = O-phospho-L-seryl-[rhodopsin] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 23356

L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)

Left to rightBalance undeterminableRhea 23360

phenylglyoxylate + H(+) = benzaldehyde + CO2

Direction not assertedBalancedRhea 23368

UDP-N-acetyl-alpha-D-muramate + L-alanine + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 23372

L-threonate + NAD(+) = 3-dehydro-D-erythronate + NADH + H(+)

Direction not assertedBalancedRhea 23376

an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)

Left to rightBalance undeterminableRhea 23380

D-cellobiose = beta-D-glucosyl-(1->4)-D-mannopyranose

Direction not assertedBalancedRhea 23384

hygromycin B + ATP = 7''-O-phosphohygromycin B + ADP + H(+)

Direction not assertedBalancedRhea 23388

RNA(n) + (n-1) H2O = n a ribonucleoside 5'-phosphate + n H(+)

Direction not assertedBalance undeterminableRhea 23392

phloretin + H2O = phloretate + 1,3,5-trihydroxybenzene + H(+)

Direction not assertedBalancedRhea 23396

7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)

Direction not assertedBalancedRhea 23400

sn-glycerol 1-phosphate + (2E,6E,10E)-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate

Direction not assertedBalancedRhea 23404

precorrin-6B + NADP(+) = precorrin-6A + NADPH + 2 H(+)

Direction not assertedBalancedRhea 23408

N-acetylputrescine + H2O = putrescine + acetate

Direction not assertedBalancedRhea 23412

(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate

Direction not assertedBalancedRhea 23416

alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate

Direction not assertedBalancedRhea 23420

Page 64 of 372