Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,101–3,150 of 18,558 reactions from Rhea

a fatty acid + S-adenosyl-L-methionine = a fatty acid methyl ester + S-adenosyl-L-homocysteine
Direction not assertedBalance undeterminableRhea 23012
(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) = (2R,3R)-dihydrokaempferol + NADPH + H(+)
Direction not assertedBalancedRhea 23016
[(1->4)-beta-D-glucosyl](n) + phosphate = [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
Direction not assertedBalance undeterminableRhea 23024
N(6)-biotinyl-L-lysyl-[protein] + malonyl-[ACP] = N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-[ACP]
Direction not assertedBalance undeterminableRhea 23028
2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)
Left to rightBalancedRhea 23032
2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O
Direction not assertedBalancedRhea 23036

2-oxobutanoate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H(+)

Direction not assertedBalancedRhea 23040

N,N-dihydroxy-L-tyrosine + H(+) = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O

Direction not assertedBalancedRhea 23044

(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate

Direction not assertedBalancedRhea 23048

L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 23052

urea = cyanamide + H2O

Direction not assertedBalancedRhea 23056

a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP = a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 23060

an alkanesulfonate + FMNH2 + O2 = an aldehyde + FMN + sulfite + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 23064

6 (S)-methylmalonyl-CoA + propanoyl-CoA + 6 NADPH + 12 H(+) = 6-deoxyerythronolide B + 6 CO2 + 6 NADP(+) + 7 CoA + H2O

Direction not assertedBalancedRhea 23068

4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH

Direction not assertedBalancedRhea 23076

L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O

Direction not assertedBalancedRhea 23080

3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate

Direction not assertedBalancedRhea 23084

O-alkylglycerone + ATP = a 1-O-alkylglycerone 3-phosphate + ADP + H(+)

Direction not assertedBalance undeterminableRhea 23088

hydroxyatrazine + H2O + H(+) = N-isopropylammelide + ethylamine

Direction not assertedBalancedRhea 23092

4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)

Direction not assertedBalancedRhea 23096

dAMP + ATP = dADP + ADP

Direction not assertedBalancedRhea 23100

D-arabinose 5-phosphate = D-ribulose 5-phosphate

Direction not assertedBalancedRhea 23104

D-arabinono-1,4-lactone + H2O = D-arabinonate + H(+)

Direction not assertedBalancedRhea 23108

6-methylsalicylate + H(+) = 3-methylphenol + CO2

Direction not assertedBalancedRhea 23112

4-hydroxybenzoate + ATP + CoA = 4-hydroxybenzoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 23116

a dipeptide(out) + ATP + H2O = a dipeptide(in) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableTransportRhea 23120

2 (2R)-3-phosphoglycerate + 2 H(+) = D-ribulose 1,5-bisphosphate + CO2 + H2O

Direction not assertedBalancedRhea 23124

4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 23128

hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] + 3 H2O = sulfite + 6 reduced [2Fe-2S]-[ferredoxin] + 7 H(+)

Direction not assertedBalance undeterminableRhea 23132

a primary amine + S-adenosyl-L-methionine = a methylated primary amine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 23136

beta-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + nicotinamide + H(+)

Direction not assertedBalancedRhea 23140

N-acetyl-alpha-D-glucosamine + NAD(+) + H2O = N-acetyl-D-glucosaminate + NADH + 2 H(+)

Direction not assertedBalancedRhea 23144

propanoate + ATP = propanoyl phosphate + ADP

Direction not assertedBalancedRhea 23148

a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)

Direction not assertedBalance undeterminableRhea 23152

(E)-(indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O

Direction not assertedBalancedRhea 23156

L-rhamnopyranose = L-rhamnulose

Direction not assertedBalancedRhea 23160

a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose = a flavonol 7-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalance undeterminableRhea 23164

coformycin + NADP(+) = 8-oxocoformycin + NADPH + H(+)

Direction not assertedBalancedRhea 23168

L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] + ATP = O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 23172

acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 23176

a secondary alcohol + O2 = a ketone + H2O2

Direction not assertedBalance undeterminableRhea 23180

(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate

Direction not assertedBalancedRhea 23184

propane-1,3-diol + NAD(+) = 3-hydroxypropanal + NADH + H(+)

Direction not assertedBalancedRhea 23188

Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP + H(+)

Direction not assertedBalancedRhea 23192

L-2-aminoadipate + L-valine + L-cysteine + 3 ATP + H2O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 3 H(+)

Direction not assertedBalancedRhea 23196

N(6)-methyl-L-lysine + O2 + H2O = L-lysine + formaldehyde + H2O2

Direction not assertedBalancedRhea 23200

chlorogenate + D-glucarate = 2-O-caffeoylglucarate + L-quinate

Direction not assertedBalancedRhea 23204

trans-glutaconate + acetyl-CoA = (2E)-glutaconyl-CoA + acetate

Direction not assertedBalancedRhea 23208

N-acetyl-beta-alanine + H2O = beta-alanine + acetate

Direction not assertedBalancedRhea 23212

benzoyl-CoA + NADPH + O2 + H(+) = 3-hydroxybenzoyl-CoA + NADP(+) + H2O

Direction not assertedBalancedRhea 23216

Page 63 of 372