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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

3,001–3,050 of 18,558 reactions from Rhea

N-succinyl-(2S,6S)-2,6-diaminopimelate + H2O = (2S,6S)-2,6-diaminopimelate + succinate
Direction not assertedBalancedRhea 22608
(3S)-citramalyl-CoA = pyruvate + acetyl-CoA
Direction not assertedBalancedRhea 22612
2 sulochrin + O2 + 2 H(+) = 2 (2R)-bisdechlorogeodin + 2 H2O
Direction not assertedBalancedRhea 22616
L-tryptophan + O2 + H(+) = 3-indoleglycolaldehyde + NH4(+) + CO2
Direction not assertedBalancedRhea 22620
(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate
Direction not assertedBalancedRhea 22624
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+)
Left to rightBalancedRhea 22628
dCTP + H2O = dCMP + diphosphate + H(+)

Direction not assertedBalancedRhea 22636

sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)

Right to leftBalancedRhea 22640

protopine + reduced [NADPH--hemoprotein reductase] + O2 = 6-hydroxyprotopine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 22644

holo-[cytochrome c] = apo-[cytochrome c] + heme b

Right to leftBalance undeterminableRhea 22648

2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate

Direction not assertedBalancedRhea 22652

CDP-ethanolamine + L-serine = L-serine-phosphoethanolamine + CMP + H(+)

Direction not assertedBalancedRhea 22656

holo-[ACP] + a fatty acid + ATP = a fatty acyl-[ACP] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 22660

2 1-O-(trans-sinapoyl)-beta-D-glucose = 1,2-di-O-sinapoyl beta-D-glucose + D-glucose

Direction not assertedBalancedRhea 22664

2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = lipid A disaccharide (E. coli) + UDP + H(+)

Direction not assertedBalancedRhea 22668

2 (2E,6E)-farnesyl diphosphate = presqualene diphosphate + diphosphate

Left to rightBalancedRhea 22672

chlorophyllide a + NADPH + O2 + H(+) = 7(1)-hydroxychlorophyllide a + NADP(+) + H2O

Direction not assertedBalancedRhea 22676

dCTP + H2O + H(+) = dUTP + NH4(+)

Left to rightBalancedRhea 22680

4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 = (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O

Direction not assertedBalance undeterminableRhea 22684

D-alanine + O2 + H2O = pyruvate + H2O2 + NH4(+)

Left to rightBalancedRhea 22688

3-hydroxybenzoate + NADH + O2 + H(+) = 2,5-dihydroxybenzoate + NAD(+) + H2O

Direction not assertedBalancedRhea 22692

androst-4-ene-3,17-dione + AH2 + O2 = testololactone + A + H2O

Direction not assertedBalancedRhea 22696

gibberellin A12 aldehyde + reduced [NADPH--hemoprotein reductase] + O2 = gibberellin A12 + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 22700

ricinine + 2 H2O = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)

Direction not assertedBalancedRhea 22704

an S-acylglutathione + H2O = a carboxylate + glutathione + H(+)

Direction not assertedBalance undeterminableRhea 22708

adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate

Direction not assertedBalancedRhea 22712

cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 22716

L-histidyl-[protein] + ATP = N(pros)-phospho-L-histidyl-[protein] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 22720

a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)

Left to rightBalance undeterminableRhea 22724

L-seryl-tRNA(Sec) + selenophosphate + H(+) = L-selenocysteinyl-tRNA(Sec) + phosphate

Direction not assertedBalancedRhea 22728

4-hydroxyphenylacetate + H(+) = 4-methylphenol + CO2

Direction not assertedBalancedRhea 22732

5-formimidoyltetrahydrofolate + 2 H(+) = (6R)-5,10-methenyltetrahydrofolate + NH4(+)

Left to rightBalancedRhea 22736

a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)

Left to rightBalancedRhea 22740

a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 22744

4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate

Direction not assertedBalancedRhea 22748

uracil + A + H2O = barbiturate + AH2 + H(+)

Direction not assertedBalancedRhea 22752

a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2

Direction not assertedBalance undeterminableRhea 22756

Cypridina luciferin + O2 = oxidized Cypridina luciferin + hnu + CO2

Direction not assertedBalance undeterminableRhea 22760

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate

Left to rightBalance undeterminableRhea 22764

4-nitrophenyl-3-ketovalidamine = 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + 4-nitroaniline

Direction not assertedBalancedRhea 22768

L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O

Direction not assertedBalancedRhea 22772

2 Mn(2+) + H2O2 + 2 H(+) = 2 Mn(3+) + 2 H2O

Direction not assertedBalancedRhea 22776

(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate

Left to rightBalancedRhea 22780

(2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite + H(+)

Direction not assertedBalancedRhea 22784

dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + L-methionine + H(+)

Direction not assertedBalancedRhea 22788

isonocardicin A = nocardicin A

Direction not assertedBalancedRhea 22792

D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 22796

cycloeucalenol = obtusifoliol

Direction not assertedBalancedRhea 22800

(6S,9R)-vomifoliol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + NADH + H(+)

Direction not assertedBalancedRhea 22804

6-hydroxynicotinate + O2 + H2O = 2,6-dihydroxynicotinate + H2O2

Direction not assertedBalancedRhea 22808

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