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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Processes
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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,951–3,000 of 18,558 reactions from Rhea

1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = guaiacol + vanillin + glycolaldehyde + H2O
Direction not assertedBalancedRhea 22396
androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + NADH + H(+)
Direction not assertedBalancedRhea 22400
beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + NADH + H(+)
Direction not assertedBalancedRhea 22404
isopentenyl diphosphate + dimethylallyl diphosphate = (2E)-geranyl diphosphate + diphosphate
Direction not assertedBalancedRhea 22408
3,4-dihydroxybenzoate + H(+) = catechol + CO2
Direction not assertedBalancedRhea 22416
cis,trans-4-hydroxymuconate semialdehyde + NAD(+) + H2O = maleylacetate + NADH + 2 H(+)
Direction not assertedBalancedRhea 22420
an S-alkyl-L-cysteine + H2O = an alkyl thiol + pyruvate + NH4(+)

Direction not assertedBalance undeterminableRhea 22424

N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O

Direction not assertedBalancedRhea 22428

a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)

ReversibleBalance undeterminableRhea 22432

(2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate

Direction not assertedBalancedRhea 22436

UDP-N-acetyl-alpha-D-glucosamine + UDP-alpha-D-galactose = UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP + H(+)

Direction not assertedBalancedRhea 22440

(E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+)

Direction not assertedBalancedRhea 22444

pseudouridine + ATP = psi-UMP + ADP + H(+)

Direction not assertedBalancedRhea 22448

[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)

Direction not assertedBalance undeterminableRhea 22452

creatine + H2O = sarcosine + urea

Direction not assertedBalancedRhea 22456

a 2,3-saturated acyl-CoA + NADP(+) = a 2,3-dehydroacyl-CoA + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 22460

L-tyrosine + reduced [NADPH--hemoprotein reductase] + O2 = N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 22464

GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate + 2 H(+)

Direction not assertedBalancedRhea 22468

(R)-pantetheine + ATP = (R)-4'-phosphopantetheine + ADP + H(+)

Direction not assertedBalancedRhea 22472

4-(hydroxyamino)quinoline N-oxide + 2 NADP(+) + H2O = 4-nitroquinoline N-oxide + 2 NADPH + 2 H(+)

Direction not assertedBalancedRhea 22476

4-(hydroxyamino)quinoline N-oxide + 2 NAD(+) + H2O = 4-nitroquinoline N-oxide + 2 NADH + 2 H(+)

Direction not assertedBalancedRhea 22480

P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H(+)

Direction not assertedBalancedRhea 22484

S-(hydroxymethyl)glutathione = glutathione + formaldehyde

Direction not assertedBalancedRhea 22488

N-formimidoyl-L-glutamate + H2O = formamide + L-glutamate

Direction not assertedBalancedRhea 22492

(E)-feruloyl-CoA + malonyl-CoA + H(+) = (E)-feruloylacetyl-CoA + CO2 + CoA

Direction not assertedBalancedRhea 22500

quercetin 3-sulfate + 3'-phosphoadenylyl sulfate = quercetin 3,3'-bissulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 22504

DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate

Left to rightBalance undeterminableRhea 22508

precorrin-8X + 3 H(+) = hydrogenobyrinate

Direction not assertedBalancedRhea 22512

taurocyamine + ATP = N-phosphotaurocyamine + ADP + H(+)

Direction not assertedBalancedRhea 22516

all-trans-retinal + O2 + H2O = all-trans-retinoate + H2O2 + H(+)

Direction not assertedBalancedRhea 22520

a carotenoid beta-end derivative + 2 A = a carotenoid phi-end derivative + 2 AH2

Direction not assertedBalance undeterminableRhea 22524

a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 22528

(2E)-octenedioyl-CoA + H2O = (3S)-hydroxyoctanedioyl-CoA

Direction not assertedBalancedRhea 22532

(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine = (S)-tetrahydropalmatine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 22536

5'-dehydroadenosine + O2 + H2O = 9-riburonosyladenine + H2O2 + H(+)

Direction not assertedBalancedRhea 22540

a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine

Direction not assertedBalance undeterminableRhea 22544

L-lysine + O2 + H2O = (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)

Direction not assertedBalancedRhea 22548

an alcohol + 3'-phosphoadenylyl sulfate = an alkyl sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 22552

(3R)-vestitone + NADP(+) = 2'-hydroxyformononetin + NADPH + 2 H(+)

Direction not assertedBalancedRhea 22560

a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)

Right to leftBalance undeterminableRhea 22564

ascopyrone M = ascopyrone P

Direction not assertedBalancedRhea 22568

N-methyl-L-glutamate + A + H2O = formaldehyde + L-glutamate + AH2

Direction not assertedBalancedRhea 22572

an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+)

Direction not assertedBalance undeterminableRhea 22576

(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O

Direction not assertedBalancedRhea 22580

heme b + 2 H(+) = protoporphyrin IX + Fe(2+)

Right to leftBalancedRhea 22584

4-aminobutanal = 1-pyrroline + H2O

Direction not assertedBalancedRhea 22588

(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (9S,13S,15Z)-12-oxophyto-10,15-dienoate

Direction not assertedBalancedRhea 22592

cephalosporin C + H2O = deacetylcephalosporin C + acetate + H(+)

Direction not assertedBalancedRhea 22596

N-acetyl-9-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate + H(+)

Left to rightBalancedRhea 22600

D-mannose = D-fructose

Direction not assertedBalancedRhea 22604

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