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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

251–300 of 18,558 reactions from Rhea

4-aminobenzoate + NADH + O2 + 2 H(+) = 4-aminophenol + CO2 + NAD(+) + H2O
Direction not assertedBalancedRhea 11052
4-aminobenzoate + NADPH + O2 + 2 H(+) = 4-aminophenol + CO2 + NADP(+) + H2O
Direction not assertedBalancedRhea 11056
tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate
Left to rightBalancedRhea 11060
beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate
Direction not assertedBalancedRhea 11064
(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose
Direction not assertedBalance undeterminableRhea 11068
anthranilate + NADPH + O2 + 3 H(+) = catechol + NH4(+) + CO2 + NADP(+)
Direction not assertedBalancedRhea 11072

anthranilate + NADH + O2 + 3 H(+) = catechol + NH4(+) + CO2 + NAD(+)

Direction not assertedBalancedRhea 11076

dTMP + H2O = thymidine + phosphate

Direction not assertedBalancedRhea 11080

3-dehydro-L-gulonate + H(+) = L-xylulose + CO2

Left to rightBalancedRhea 11084

trimetaphosphate + H2O = triphosphate + 2 H(+)

Direction not assertedBalancedRhea 11088

sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)

Left to rightBalancedRhea 11092

sn-glycerol 3-phosphate + NADP(+) = dihydroxyacetone phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 11096

4-hydroxyhexan-3-one = 2 propanal

Direction not assertedBalancedRhea 11100

N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine = hercynine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 11104

chondroitin beta-D-glucuronate + n 3'-phosphoadenylyl sulfate = chondroitin 6'-sulfate + n adenosine 3',5'-bisphosphate + n H(+)

Left to rightBalance undeterminableRhea 11108

isochorismate + H2O = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Direction not assertedBalancedRhea 11112

an alkane-alpha,omega-diamine + acetyl-CoA = an N-acetylalkane-alpha,omega-diamine + CoA + H(+)

Left to rightBalance undeterminableRhea 11116

cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2

Direction not assertedBalancedRhea 11120

(E)-4-coumaroyl-CoA + 3 malonyl-CoA + 3 H(+) = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA

Direction not assertedBalancedRhea 11128

chlorophyllide a + NADP(+) = protochlorophyllide a + NADPH + H(+)

Direction not assertedBalancedRhea 11132

a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)

Left to rightBalance undeterminableRhea 11136

alpha-D-mannose 1-phosphate = D-mannose 6-phosphate

Direction not assertedBalancedRhea 11140

4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O

ReversibleBalancedRhea 11148

5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)

Direction not assertedBalancedRhea 11152

L-valine + NADP(+) + H2O = 3-methyl-2-oxobutanoate + NH4(+) + NADPH + H(+)

Direction not assertedBalancedRhea 11156

L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate

Direction not assertedBalancedRhea 11160

a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 11164

3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) = 3-oxo-6-carboxyhexanoyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 11168

(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine

Left to rightBalancedRhea 11172

kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose

Direction not assertedBalancedRhea 11176

tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 11180

3-(carbamoylamino)propanoate + H2O + 2 H(+) = beta-alanine + NH4(+) + CO2

Left to rightBalancedRhea 11184

3-cyano-L-alanine + 2 H2O = L-aspartate + NH4(+)

Direction not assertedBalancedRhea 11188

an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)

Direction not assertedBalance undeterminableRhea 11192

5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + nicotinate + H(+)

Direction not assertedBalancedRhea 11196

apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + biotin + ATP = holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + AMP + diphosphate + H(+)

Left to rightBalance undeterminableRhea 11204

indole + O2 = 2-formamidobenzaldehyde

Direction not assertedBalancedRhea 11212

a 2'-deoxyribonucleoside 5'-phosphate + ATP = a 2'-deoxyribonucleoside 5'-diphosphate + ADP

Direction not assertedBalance undeterminableRhea 11216

a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 11220

2 D-alanine + ATP = D-alanyl-D-alanine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 11224

(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + NADPH + H(+)

Direction not assertedBalancedRhea 11228

3'-phosphoadenylyl sulfate + H2O = sulfate + adenosine 3',5'-bisphosphate + 2 H(+)

Direction not assertedBalancedRhea 11232

putrescine + spermidine = sym-homospermidine + propane-1,3-diamine

Direction not assertedBalancedRhea 11236

thiamine diphosphate + ATP = thiamine triphosphate + ADP

Direction not assertedBalancedRhea 11240

[(3R)-hydroxybutanoate](n) + H2O = [(3R)-hydroxybutanoate](n-1) + (R)-3-hydroxybutanoate + H(+)

Direction not assertedBalance undeterminableRhea 11248

hydroxylamine + L-asparagine + H(+) = beta-L-aspartylhydroxamate + NH4(+)

Direction not assertedBalancedRhea 11252

limonin + UDP-alpha-D-glucose + H2O = limonin 17-beta-D-glucoside + UDP + 2 H(+)

Direction not assertedBalancedRhea 11256

NADPH + O2 + H(+) = H2O2 + NADP(+)

Left to rightBalancedRhea 11260

NADH + O2 + H(+) = H2O2 + NAD(+)

Direction not assertedBalancedRhea 11264

D-cysteine + H2O = hydrogen sulfide + pyruvate + NH4(+) + H(+)

Direction not assertedBalancedRhea 11268

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