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Subsystem: Drug metabolism Remove
251–300 of 572 reactions in Drug metabolism
UDP-glucuronate[r] + cerivastatin-M23[r] = H+[r] + UDP[r] + cerivastatin-M23-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR12558
acetyl-CoA[c] + cysteine-conjugate-acetaminophen[c] = CoA[c] + H+[c] + acetaminophen-mercapturate-conjugate/N-acetyl-cysteine-acetaminophen[c]
Left to rightBalancedHuman-GEM MAR12559
ATP[c] + H2O[c] + cysteine-conjugate-acetaminophen[c] = ADP[c] + H+[c] + Pi[c] + cysteine-conjugate-acetaminophen[e]
Left to rightBalancedTransportHuman-GEM MAR12560
H+[c] + H2O[c] + SAH[c] + cerivastatin-M31[c] = SAM[c] + cerivastatin-M23[c]
Left to rightBalancedHuman-GEM MAR12561
CoA[x] + H2O[x] + NAD+[x] + fluvastatin[x] = acetyl-CoA[x] + H+[x] + H2O2[x] + NADH[x] + deoxy-fluvastatin-dinor[x]
deoxy-fluvastatin-dinor[c] = deoxy-fluvastatin-dinor[e]
ReversibleBalancedTransportHuman-GEM MAR12563
4 H+[r] + NADPH[r] + O2[r] + 3 SAH[r] + fluvastatin[r] = H2O2[r] + NADP+[r] + 3 SAM[r] + N-desisopropyl-fluvastatin[r]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12564
ATP[c] + H2O[c] + N-desisopropyl-fluvastatin[c] = ADP[c] + H+[c] + Pi[c] + N-desisopropyl-fluvastatin[e]
Left to rightBalancedTransportHuman-GEM MAR12565
ATP[c] + H2O[c] + dehydro-gliclazide[c] = ADP[c] + H+[c] + Pi[c] + dehydro-gliclazide[e]
Left to rightBalancedTransportHuman-GEM MAR12566
NADP+[c] + Gliclazide[c] = H+[c] + NADPH[c] + dehydro-gliclazide[c]
Left to rightBalancedHuman-GEM MAR12567
dehydro-gliclazide[c] = dehydro-gliclazide[e]
ReversibleBalancedTransportHuman-GEM MAR12568
6 H+[r] + NADPH[r] + 5 SAH[r] + pravastatin[r] = 2 H2O[r] + NADP+[r] + 5 SAM[r] + desacyl dehydro-pravastatin[r]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12569
ATP[c] + H2O[c] + desacyl dehydro-pravastatin[c] = ADP[c] + H+[c] + Pi[c] + desacyl dehydro-pravastatin[e]
Left to rightBalancedTransportHuman-GEM MAR12570
desacyl dehydro-pravastatin[c] = desacyl dehydro-pravastatin[e]
ReversibleBalancedTransportHuman-GEM MAR12571
3 H+[r] + O2[r] + 3 SAH[r] + Tacrolimus[r] = 3 SAM[r] + 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus[r]
Left to rightBalancedHuman-GEM MAR12572
ATP[c] + H2O[c] + 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus[c] = ADP[c] + H+[c] + Pi[c] + 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus[e]
Left to rightBalancedTransportHuman-GEM MAR12573
31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus[c] = 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus[e]
Left to rightBalancedTransportHuman-GEM MAR12574
UDP-glucuronate[r] + fluvastatin[r] = H+[r] + UDP[r] + fluvstatin-glucuronide[r]
Left to rightBalancedHuman-GEM MAR12720
UDP-glucuronate[r] + des-isopropyl-dihydro-fluvastatin-tetranor[r] = H+[r] + UDP[r] + des-isopropyl-dihydro-fluvastatin-tetranor-glucuronide[r]
Left to rightBalancedHuman-GEM MAR12721
des-isopropyl-dihydro-fluvastatin-tetranor-glucuronide[c] = des-isopropyl-dihydro-fluvastatin-tetranor-glucuronide[e]
ReversibleBalancedTransportHuman-GEM MAR12722
des-isopropyl-dihydro-fluvastatin-tetranor[c] = des-isopropyl-dihydro-fluvastatin-tetranor[e]
ReversibleBalancedTransportHuman-GEM MAR12723
H2O[r] + trans-lactone-fluvastatin[r] = fluvastatin[r]
Left to rightBalancedHuman-GEM MAR12724
ATP[c] + H2O[c] + fluvastatin[c] = ADP[c] + H+[c] + Pi[c] + fluvastatin[e]
Left to rightBalancedTransportHuman-GEM MAR12725
fluvastatin[c] = fluvastatin[e]
ReversibleBalancedTransportHuman-GEM MAR12726
HCO3-[c] + fluvastatin[e] = HCO3-[e] + fluvastatin[c]
ReversibleBalancedTransportHuman-GEM MAR12727
SAH[r] + UDP-glucuronate[r] + 3-methoxy-acetaminophen[r] = SAM[r] + UDP[r] + glucuronide-conjugate of 3-methoxy-acetaminophen[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR12728
ATP[c] + H2O[c] + glucuronide-conjugate of 3-methoxy-acetaminophen[c] = ADP[c] + H+[c] + Pi[c] + glucuronide-conjugate of 3-methoxy-acetaminophen[e]
Left to rightBalancedTransportHuman-GEM MAR12729
ATP[c] + H2O[c] + Gliclazide[c] = ADP[c] + H+[c] + Pi[c] + Gliclazide[e]
Left to rightBalancedTransportHuman-GEM MAR12730
Gliclazide[e] = Gliclazide[c]
ReversibleBalancedTransportHuman-GEM MAR12731
UDP-glucuronate[r] + thiomethyl-conjugate-acetaminophen[r] = H+[r] + UDP[r] + glucuronide-thiomethyl-acetaminophen conjugate[r]
Left to rightBalancedHuman-GEM MAR12732
ATP[c] + H2O[c] + glucuronide-thiomethyl-acetaminophen conjugate[c] = ADP[c] + H+[c] + Pi[c] + glucuronide-thiomethyl-acetaminophen conjugate[e]
Left to rightBalancedTransportHuman-GEM MAR12733
ibuprofen acyl glucuronide[e] = ibuprofen acyl glucuronide[c]
ReversibleBalancedTransportHuman-GEM MAR12734
ATP[c] + H2O[c] + ibuprofen acyl glucuronide[c] = ADP[c] + H+[c] + Pi[c] + ibuprofen acyl glucuronide[e]
Left to rightBalancedTransportHuman-GEM MAR12735
UDP-glucuronate[r] + ibuprofen-S[r] = UDP[r] + ibuprofen acyl glucuronide[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR12736
ATP[c] + CoA[c] + ibuprofen-R[c] = AMP[c] + PPi[c] + ibuprofen-CoA-R form[c]
Left to rightBalancedEC 6.2.1.3Human-GEM MAR12737
H+[r] + NADPH[r] + O2[r] + ibuprofen-R[r] = H2O[r] + NADP+[r] + 2-hydroxy-R-ibuprofen[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12738
H+[r] + NADPH[r] + O2[r] + ibuprofen-R[r] = H2O[r] + NADP+[r] + 3-hydroxy R-ibuprofen[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12739
O2[c] + 3-hydroxy R-ibuprofen[c] = H+[c] + H2O[c] + R-carboxy ibuprofen[c]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12740
ibuprofen-CoA-R form[c] = ibuprofen-CoA-S form[c]
ReversibleBalancedEC 5.1.99.4Human-GEM MAR12741
urate[c] + ibuprofen-R[e] = urate[e] + ibuprofen-R[c]
ReversibleBalancedTransportHuman-GEM MAR12742
ibuprofen-R[e] = ibuprofen-R[c]
ReversibleBalancedTransportHuman-GEM MAR12743
H2O[c] + ibuprofen-CoA-S form[c] = CoA[c] + H+[c] + ibuprofen-S[c]
Left to rightBalancedEC 3.1.2.2, 3.1.2.27, 3.1.2.-Human-GEM MAR12744
taurine[c] + ibuprofen-CoA-S form[c] = CoA[c] + H+[c] + taurine conjugate of S-ibuprofen[c]
Left to rightBalancedHuman-GEM MAR12745
H+[r] + NADPH[r] + O2[r] + ibuprofen-S[r] = 1-hydroxy S-ibuprofen[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12746
H+[r] + NADPH[r] + O2[r] + ibuprofen-S[r] = H2O[r] + NADP+[r] + 2-hydroxy-S-ibuprofen[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12747
H+[r] + NADPH[r] + O2[r] + ibuprofen-S[r] = H2O[r] + NADP+[r] + 3-hydroxy S-ibuprofen[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12748
O2[c] + 3-hydroxy S-ibuprofen[c] = H+[c] + H2O[c] + S-carboxy ibuprofen[c]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12749
ATP[c] + H2O[c] + ibuprofen-S[c] = ADP[c] + H+[c] + Pi[c] + ibuprofen-S[e]
Left to rightBalancedTransportHuman-GEM MAR12750
urate[c] + ibuprofen-S[e] = urate[e] + ibuprofen-S[c]
ReversibleBalancedTransportHuman-GEM MAR12751
ibuprofen-S[e] = ibuprofen-S[c]
ReversibleBalancedTransportHuman-GEM MAR12752