Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,901–2,950 of 18,558 reactions from Rhea

an (R)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)
Direction not assertedBalance undeterminableRhea 22188
(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate
Left to rightBalancedRhea 22192
trans-aconitate + S-adenosyl-L-methionine = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine
Direction not assertedBalancedRhea 22200
3-hydroxyphenylacetate + NADPH + O2 + H(+) = homogentisate + NADP(+) + H2O
Direction not assertedBalancedRhea 22204
3-hydroxyphenylacetate + NADH + O2 + H(+) = homogentisate + NAD(+) + H2O
Direction not assertedBalancedRhea 22208
(2R,3R)-tartrate = (2R,3S)-tartrate
Direction not assertedBalancedRhea 22212

(E)-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)

Direction not assertedBalancedRhea 22216

ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate

Direction not assertedBalancedRhea 22220

N-methylanthraniloyl-CoA + 3 malonyl-CoA + 3 H(+) = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O

Direction not assertedBalancedRhea 22224

presqualene diphosphate + NADH + H(+) = squalene + diphosphate + NAD(+)

Left to rightBalancedRhea 22228

presqualene diphosphate + NADPH + H(+) = squalene + diphosphate + NADP(+)

Left to rightBalancedRhea 22232

2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate

Direction not assertedBalancedRhea 22236

methylenediurea + H2O = N-(carboxyaminomethyl)urea + NH4(+)

Direction not assertedBalancedRhea 22240

kaempferol + UDP-alpha-D-xylose = kaempferol 3-O-beta-D-xyloside + UDP + H(+)

Direction not assertedBalancedRhea 22244

7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + NADH + H(+)

Direction not assertedBalancedRhea 22248

a globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a globoside Gb4Cer (d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 22252

a (3R)-3-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 22256

triacetate lactone + H2O = 3,5-dioxohexanoate + H(+)

Direction not assertedBalancedRhea 22260

3,5,6-trichloropyridin-2-ol + FADH2 + O2 = 3,6-dichloropyridine-2,5-dione + FAD + chloride + H2O + 2 H(+)

Direction not assertedBalancedRhea 22264

streptomycin + ATP = streptomycin 6-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 22268

(20S)-protopanaxadiol + reduced [NADPH--hemoprotein reductase] + O2 = (20S)-protopanaxatriol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 22272

2-oxoaldehyde + NAD(+) + H2O = a 2-oxocarboxylate + NADH + 2 H(+)

Direction not assertedBalance undeterminableRhea 22276

O-demethylpuromycin + S-adenosyl-L-methionine = puromycin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 22280

N-carbamoylputrescine + H2O + 2 H(+) = putrescine + NH4(+) + CO2

Direction not assertedBalancedRhea 22284

an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an oligoglycosyl-(1->4)-D-glucose + an N-acyl-sphingoid base

Direction not assertedBalance undeterminableRhea 22288

benzoyl-CoA + 3 malonyl-CoA + 3 H(+) = biphenyl-3,5-diol + 4 CO2 + 4 CoA

Direction not assertedBalancedRhea 22292

2 (2E,6E,10E)-geranylgeranyl diphosphate = (1R,2R,3R)-prephytoene diphosphate + diphosphate

Direction not assertedBalancedRhea 22296

a flavonol + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalance undeterminableRhea 22300

keto-D-fructose + a ubiquinone = 5-dehydro-D-fructose + a ubiquinol

Direction not assertedBalance undeterminableRhea 22304

xylitol + O2 = D-xylose + H2O2

Direction not assertedBalancedRhea 22308

5-(methylsulfanyl)-D-ribose + ATP = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 22312

13-hydroxydocosanoate + UDP-alpha-D-glucose = 13-(beta-D-glucosyloxy)docosanoate + UDP + H(+)

Direction not assertedBalancedRhea 22316

2 alpha-D-glucose 1-phosphate + H2O = D-maltose + 2 phosphate

Direction not assertedBalancedRhea 22320

leukotriene A4 + H2O = leukotriene B4

Left to rightBalancedRhea 22324

4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate

Direction not assertedBalancedRhea 22328

(3R)-citramalate = 2-methylmaleate + H2O

Direction not assertedBalancedRhea 22332

L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine

Left to rightBalancedRhea 22336

3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + NADPH + H(+)

Direction not assertedBalancedRhea 22340

(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA = (R)-rosmarinate + CoA

Direction not assertedBalancedRhea 22344

4-aminoimidazole + H2O + H(+) = imidazol-4-one + NH4(+)

Direction not assertedBalancedRhea 22348

L-lysine + H(+) = cadaverine + CO2

Direction not assertedBalancedRhea 22352

oxaloacetate + diphosphate = phosphoenolpyruvate + CO2 + phosphate

Direction not assertedBalancedRhea 22356

D-glutamate = 5-oxo-D-proline + H2O

Direction not assertedBalancedRhea 22360

L-quinate + NAD(+) = 3-dehydroquinate + NADH + H(+)

Direction not assertedBalancedRhea 22364

L-ribulose 5-phosphate = D-xylulose 5-phosphate

Direction not assertedBalancedRhea 22368

propionate 3-nitronate + O2 + H2O = 3-oxopropanoate + nitrite + H2O2 + H(+)

Direction not assertedBalancedRhea 22372

uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA

Left to rightBalancedRhea 22376

[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1->4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)

Direction not assertedBalance undeterminableRhea 22380

5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)

Left to rightBalancedRhea 22384

N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA

Direction not assertedBalancedRhea 22388

Page 59 of 372