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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Interactions
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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

29,051–29,100 of 31,435, by identifier

5-S-cysteinyldopa + L-dopaquinone = 5-S-cysteinyldopaquinone + L-dopa
Direction not assertedBalancedRhea 77095
5-hydroxymethyl-dUMP + H2O = 5-hydroxymethyluracil + 2-deoxy-D-ribose 5-phosphate
Left to rightBalancedRhea 77099
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)
Direction not assertedBalancedRhea 77103
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)
Direction not assertedBalancedRhea 77107
1D-myo-inositol 1,2,3,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,6-tetrakisphosphate + phosphate
Left to rightBalancedRhea 77111
1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate
Left to rightBalancedRhea 77115

1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate

Left to rightBalancedRhea 77119

1D-myo-inositol 1,2,3,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,3-trisphosphate + phosphate

Left to rightBalancedRhea 77123

1D-myo-inositol 1,2,3-trisphosphate + H2O = 1D-myo-inositol 2,3-bisphosphate + phosphate

Left to rightBalancedRhea 77127

1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-bisphosphate + phosphate

Left to rightBalancedRhea 77131

1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate

Left to rightBalancedRhea 77135

1D-myo-inositol 2,3-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate

Left to rightBalancedRhea 77139

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate

Left to rightBalancedRhea 77143

1D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate

Left to rightBalancedRhea 77147

1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 4,5-bisphosphate + phosphate

Direction not assertedBalancedRhea 77151

1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate

Left to rightBalancedRhea 77155

selenophosphate + UDP-N-acetyl-alpha-D-glucosamine + H2O = N-acetyl-1-seleno-beta-D-glucosamine + UDP + phosphate + H(+)

Direction not assertedBalancedRhea 77159

N-acetyl-1-seleno-beta-D-glucosamine + hercynine + O2 + H(+) = hercynyl-SeGlcNAc selenoxide + H2O

Direction not assertedBalancedRhea 77163

hercynyl-SeGlcNAc selenoxide + AH2 = 2-acetamidoglucal + selenoneine + A + H2O

Direction not assertedBalancedRhea 77167

biocytin + H2O = biotin + L-lysine

Direction not assertedBalancedRhea 77171

5-hydroxymethyl-dCMP + H2O + H(+) = 5-hydroxymethyl-dUMP + NH4(+)

Left to rightBalancedRhea 77175

(5'S,6'R)-C-glycyluridine + O2 = uridine-5'-carboxamide + CO2 + H2O

Direction not assertedBalancedRhea 77179

uridine-5'-aldehyde + L-threonine = (5'S,6'S)-C-glycyluridine + acetaldehyde

Direction not assertedBalancedRhea 77183

beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)

Left to rightBalancedRhea 77187

an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)

Left to rightBalance undeterminableRhea 77191

(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA

Left to rightBalancedRhea 77195

3beta-hydroxy-5-cholenate + 3'-phosphoadenylyl sulfate = 3beta-sulfo-5-cholenate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 77199

deoxycholate + 3'-phosphoadenylyl sulfate = deoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 77203

glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 77207

taurodeoxycholate + 3'-phosphoadenylyl sulfate = taurodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 77211

dATP + H2O = 2-deoxyribose 5-triphosphate + adenine

Direction not assertedBalancedRhea 77215

L-tryptophyl-[protein] + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = C-alpha-D-mannosyl-L-tryptophyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)

Left to rightBalance undeterminableRhea 77219

gentamicin X2 + methylcob(III)alamin + S-adenosyl-L-methionine = geneticin + cob(III)alamin + 5'-deoxyadenosine + L-methionine

Direction not assertedBalancedRhea 77223

gentamicin X2 + AH2 + 2 S-adenosyl-L-methionine = geneticin + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 77227

cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + H2O = (S)-2-hydroxypropylphosphonate + CMP + H(+)

Direction not assertedBalancedRhea 77231

salicyl-[ACP] + L-threonyl-[peptidyl-carrier protein] = salicylmethyloxazolinyl-[peptidyl-carrier protein] + holo-[ACP] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 77235

pre-pseudomonine = pseudomonine

Direction not assertedBalancedRhea 77239

hnu + octadecanoate + H(+) = heptadecane + CO2

Direction not assertedBalance undeterminableRhea 77243

O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + H2O = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate

Left to rightBalance undeterminableRhea 77247

[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-3-O-methyl-D-mannose + GDP-alpha-D-mannose = alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-3-O-methyl-D-mannose + GDP + H(+)

Direction not assertedBalance undeterminableRhea 77251

a beta-D-glucosylceramide(in) = a beta-D-glucosylceramide(out)

Direction not assertedBalance undeterminableTransportRhea 77255

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out)

Direction not assertedBalance undeterminableTransportRhea 77259

beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine(in) = beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine(out)

Direction not assertedBalancedTransportRhea 77263

1-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,3-di-(9Z-octadecenoyl)-glycerol + CoA

Left to rightBalancedRhea 77267

2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

Left to rightBalancedRhea 77271

2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

Left to rightBalancedRhea 77275

2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

Left to rightBalancedRhea 77279

2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

Left to rightBalancedRhea 77283

2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

Left to rightBalancedRhea 77287

2-(9Z-octadecenoyl)-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA

Left to rightBalancedRhea 77291

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