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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Processes
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Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,851–2,900 of 18,558 reactions from Rhea

pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside + malonyl-CoA = 4'''-demalonylsalvianin + CoA
Direction not assertedBalancedRhea 21988
L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)
Left to rightBalance undeterminableRhea 21992
a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA
Direction not assertedBalance undeterminableRhea 21996
D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)
Direction not assertedBalancedRhea 22000
L-seryl-[myosin light chain] + ATP = O-phospho-L-seryl-[myosin light chain] + ADP + H(+)
Left to rightBalance undeterminableRhea 22004
L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA
Direction not assertedBalancedRhea 22008
precorrin-4 + S-adenosyl-L-methionine = precorrin-5 + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 22012

[glutaredoxin]-dithiol + arsenate + glutathione + H(+) = glutathionyl-S-S-[glutaredoxin] + arsenite + H2O

Direction not assertedBalance undeterminableRhea 22016

molybdate(out) + ATP + H2O = molybdate(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 22020

trimethylamine + NAD(+) + H2O = trimethylamine N-oxide + NADH + 2 H(+)

Direction not assertedBalancedRhea 22024

taxa-4(20),11-dien-5alpha-ol + acetyl-CoA = taxa-4(20),11-dien-5alpha-yl acetate + CoA

Direction not assertedBalancedRhea 22028

3-oxalomalate = oxaloacetate + glyoxylate

Direction not assertedBalancedRhea 22032

[phosphate](n) + D-glucose = [phosphate](n-1) + D-glucose 6-phosphate + H(+)

Direction not assertedBalance undeterminableRhea 22036

N-formyl-L-aspartate + H2O = L-aspartate + formate

Direction not assertedBalancedRhea 22040

K(+)(out) + ATP + H2O + H(+)(in) = K(+)(in) + ADP + phosphate + 2 H(+)(out)

Left to rightBalancedTransportRhea 22044

7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate + H(+)

Direction not assertedBalancedRhea 22048

A + NH4(+) + H2O = hydroxylamine + AH2 + H(+)

Direction not assertedBalancedRhea 22052

hexadecan-1-ol + NAD(+) = hexadecanal + NADH + H(+)

Direction not assertedBalancedRhea 22056

(4R,5S)-dethiobiotin + (sulfur carrier)-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (sulfur carrier)-H + biotin + 2 5'-deoxyadenosine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]

Direction not assertedBalance undeterminableRhea 22060

5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O

Direction not assertedBalancedRhea 22064

(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)

Direction not assertedBalancedRhea 22068

L-ribulose + ATP = L-ribulose 5-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 22072

[protein] with 2 [4Fe-4S] clusters + sulfite + 6 AH2 + 2 S-adenosyl-L-methionine = [protein] with [8Fe-9S-C] cluster + 5'-deoxyadenosine + L-methionine + 6 A + S-adenosyl-L-homocysteine + 3 H2O + 8 H(+)

Direction not assertedBalance undeterminableRhea 22076

quinolin-2-ol + NADH + O2 + H(+) = quinoline-2,8-diol + NAD(+) + H2O

Direction not assertedBalancedRhea 22080

(S)-2,3-diaminopropanoate + H2O + H(+) = pyruvate + 2 NH4(+)

Direction not assertedBalancedRhea 22084

GTP + ATP = guanosine 3'-diphosphate 5'-triphosphate + AMP

Direction not assertedBalancedRhea 22088

(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] = 15,16-dihydrobiliverdin + reduced 2[4Fe-4S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 22092

RNA(n+1) + phosphate = RNA(n) + a ribonucleoside 5'-diphosphate

Left to rightBalance undeterminableRhea 22096

3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4(+)

Direction not assertedBalancedRhea 22100

nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate

Direction not assertedBalancedRhea 22104

L-threonine = 2-oxobutanoate + NH4(+)

Direction not assertedBalancedRhea 22108

isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)

Direction not assertedBalancedRhea 22112

luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate = luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP + H(+)

Direction not assertedBalancedRhea 22116

GTP + succinate + CoA = succinyl-CoA + GDP + phosphate

Direction not assertedBalancedRhea 22120

17-O-acetylajmaline + H2O = ajmaline + acetate + H(+)

Direction not assertedBalancedRhea 22124

(1S,2R,4S)-borneol + NAD(+) = (1S,4S)-camphor + NADH + H(+)

Direction not assertedBalancedRhea 22128

D-maltose(out) + ATP + H2O = D-maltose(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 22132

7(1)-hydroxychlorophyllide a + NADPH + O2 + H(+) = chlorophyllide b + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 22136

a nucleoside 5'-phosphate + H2O = a nucleoside + phosphate

Direction not assertedBalance undeterminableRhea 22140

cis-aconitate + H2O = D-threo-isocitrate

Direction not assertedBalancedRhea 22144

2 oxidized [plastocyanin] + a plastoquinol + 2 H(+)(in) = 2 reduced [plastocyanin] + a plastoquinone + 4 H(+)(out)

Direction not assertedBalance undeterminableTransportRhea 22148

a ubiquinone + D-glucose = D-glucono-1,5-lactone + a ubiquinol

Direction not assertedBalance undeterminableRhea 22152

GDP + H2O = GMP + phosphate + H(+)

Left to rightBalancedRhea 22156

a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + 4-coumaroyl-CoA = a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA

Direction not assertedBalance undeterminableRhea 22160

a globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a globoside Forssman (d18:1(4E)) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 22164

UDP-alpha-D-glucose = UDP-alpha-D-galactose

Direction not assertedBalancedRhea 22168

beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = sucrose 6(F)-phosphate + UDP + H(+)

Direction not assertedBalancedRhea 22172

leukotriene B4 + reduced [NADPH--hemoprotein reductase] + O2 = 20-hydroxy-leukotriene B4 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 22176

(S)-norreticuline + S-adenosyl-L-methionine = (S)-norcodamine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 22180

(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 NADPH + 2 H(+)

Direction not assertedBalancedRhea 22184

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