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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
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PathwaysReactions grouped under one name
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Reference

Evidence

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Outcomes
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Interactions
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Reactions
Reach

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Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,801–2,850 of 18,558 reactions from Rhea

heme b + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = biliverdin IXalpha + CO + Fe(2+) + 3 oxidized [NADPH--hemoprotein reductase] + 3 H2O + H(+)
Left to rightBalance undeterminableRhea 21764
N-methyl-L-alanine + NADP(+) + H2O = methylamine + pyruvate + NADPH + H(+)
Direction not assertedBalancedRhea 21768
cytidine(6666) in apoB mRNA + H2O + H(+) = uridine(6666) in apoB mRNA + NH4(+)
Left to rightBalancedRhea 21772
(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate
Direction not assertedBalancedRhea 21776
cyclohexanone + A = cyclohex-2-enone + AH2
Direction not assertedBalancedRhea 21780
N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2-oxoglutarate + O2 = N(6)-methyl-L-lysyl(36)-[histone H3] + formaldehyde + succinate + CO2
Left to rightBalance undeterminableRhea

21788

propan-2-ol + NADP(+) = acetone + NADPH + H(+)

Direction not assertedBalancedRhea 21792

dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + NADPH + H(+)

Direction not assertedBalancedRhea 21796

all-trans-antheraxanthin + L-ascorbate = all-trans-zeaxanthin + L-dehydroascorbate + H2O

Direction not assertedBalancedRhea 21800

myo-inositol + ATP = 1D-myo-inositol 3-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 21804

2,5-dioxopiperazine + H2O = glycylglycine

Direction not assertedBalancedRhea 21808

cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 21812

a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)

Left to rightBalance undeterminableRhea 21816

L-homocysteine + S-adenosyl-L-methionine = L-methionine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 21820

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Left to rightBalancedRhea 21824

nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = nitrate + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 21828

3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 21832

D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O

Direction not assertedBalancedRhea 21836

N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 21840

phenylacetyl-CoA + L-glutamine = N(2)-phenylacetyl-L-glutamine + CoA + H(+)

Direction not assertedBalancedRhea 21844

(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide

Direction not assertedBalancedRhea 21848

(R)-10-hydroxyoctadecanoate = (9Z)-octadecenoate + H2O

Direction not assertedBalancedRhea 21852

cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA

Direction not assertedBalancedRhea 21856

quercetin 3,3'-bissulfate + 3'-phosphoadenylyl sulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 21860

an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)

Left to rightBalance undeterminableRhea 21864

2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O + H(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)

Direction not assertedBalancedRhea 21868

(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + NADH + 2 H(+)

Direction not assertedBalancedRhea 21876

oxalate + O2 + 2 H(+) = H2O2 + 2 CO2

Direction not assertedBalancedRhea 21880

trithionate + H2O = thiosulfate + sulfate + H(+)

Direction not assertedBalancedRhea 21884

(1S,2S)-OPC-8 + NADP(+) = (9S,13S,15Z)-12-oxophyto-10,15-dienoate + NADPH + H(+)

Direction not assertedBalancedRhea 21888

D-arabinose + NADP(+) = D-arabinono-1,4-lactone + NADPH + H(+)

Direction not assertedBalancedRhea 21892

(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide phosphate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 21896

scytalone + NADP(+) = naphthalene-1,3,6,8-tetrol + NADPH + H(+)

Direction not assertedBalancedRhea 21908

pyruvate + CoA + O2 + H(+) = acetyl-CoA + H2O2 + CO2

Direction not assertedBalancedRhea 21912

2 Fe(III)-[cytochrome c550] + an aliphatic amine + H2O = 2 Fe(II)-[cytochrome c550] + an aldehyde + NH4(+) + 2 H(+)

Direction not assertedBalance undeterminableRhea 21916

UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine + di-trans,octa-cis-undecaprenyl phosphate = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP

Direction not assertedBalancedRhea 21920

3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + NADH + H(+)

Direction not assertedBalancedRhea 21924

3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + NADPH + H(+)

Direction not assertedBalancedRhea 21928

S-adenosyl-L-methionine = L-homoserine lactone + S-methyl-5'-thioadenosine

Direction not assertedBalancedRhea 21932

carbamoyl phosphate + putrescine = N-carbamoylputrescine + phosphate + H(+)

Direction not assertedBalancedRhea 21936

D-cellobiose + ATP = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)

Direction not assertedBalancedRhea 21944

formamide + H2O = formate + NH4(+)

Direction not assertedBalancedRhea 21948

5alpha-pregnane-3,20-dione + NADP(+) = progesterone + NADPH + H(+)

Right to leftBalancedRhea 21952

vitexin + UDP-alpha-D-glucose = vitexin 2''-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 21956

an acylcholine + H2O = a carboxylate + choline + H(+)

Direction not assertedBalance undeterminableRhea 21964

7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate

Direction not assertedBalancedRhea 21968

precorrin-1 + S-adenosyl-L-methionine = precorrin-2 + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 21972

[thioredoxin]-disulfide + sulfite + AMP + 2 H(+) = adenosine 5'-phosphosulfate + [thioredoxin]-dithiol

Direction not assertedBalance undeterminableRhea 21976

alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + 2 H(+)

Left to rightBalance undeterminableRhea 21980

choline + 3'-phosphoadenylyl sulfate = choline sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 21984

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