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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

28,101–28,150 of 31,435, by identifier

3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine = 4',7,8-trihydroxy-3'-methoxyflavone-7-olate + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 73275
L-isoleucine(in) + H(+)(out) = L-isoleucine(out) + H(+)(in)
Direction not assertedBalancedTransportRhea 73283
(2S)-naringenin + S-adenosyl-L-methionine = (2S)-naringenin 4'-methyl ether + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 73287
L-valine(in) + H(+)(out) = L-valine(out) + H(+)(in)
Direction not assertedBalancedTransportRhea 73291
4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 7,8-dihydroxy-4'-methoxyflavone + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 73295
(S)-malate(out) + phosphate(in) + H(+)(in) = (S)-malate(in) + phosphate(out) + H(+)(out)
Direction not assertedBalancedTransport

Rhea 73299

oxaloacetate(out) + phosphate(in) + H(+)(in) = oxaloacetate(in) + phosphate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 73303

L-aspartate(out) + phosphate(in) + H(+)(in) = L-aspartate(in) + phosphate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 73307

L-thyroxine sulfate(out) = L-thyroxine sulfate(in)

Direction not assertedBalancedTransportRhea 73311

1D-chiro-inositol(out) + 2 Na(+)(out) = 1D-chiro-inositol(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 73315

(2R,3S)-piscidate + (E)-4-coumaroyl-CoA = cimicifugate K + CoA

Direction not assertedBalancedRhea 73319

(2R,3S)-piscidate + (E)-caffeoyl-CoA = cimicifugate D + CoA

Direction not assertedBalancedRhea 73323

(2R,3S)-piscidate + (E)-sinapoyl-CoA = cimicifugate J + CoA

Direction not assertedBalancedRhea 73327

(2R,3S)-piscidate + (E)-feruloyl-CoA = cimicifugate E + CoA

Direction not assertedBalancedRhea 73331

tryptamine + beta-alanine + ATP = beta-alanyl-tryptamine + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 73335

beta-alanine + ATP + H(+) = beta-alanyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 73339

beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein] = beta-alanyl-[peptidyl-carrier protein] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 73343

beta-alanyl-[peptidyl-carrier protein] + tryptamine = beta-alanyl-tryptamine + holo-[peptidyl-carrier protein] + H(+)

Direction not assertedBalance undeterminableRhea 73347

histamine + beta-alanine + ATP = carcinine + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 73351

beta-alanyl-[peptidyl-carrier protein] + histamine = carcinine + holo-[peptidyl-carrier protein] + H(+)

Direction not assertedBalance undeterminableRhea 73355

dopamine + beta-alanine + ATP = beta-alanyl-dopamine + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 73359

beta-alanyl-[peptidyl-carrier protein] + dopamine = beta-alanyl-dopamine + holo-[peptidyl-carrier protein] + H(+)

Direction not assertedBalance undeterminableRhea 73363

D-xylose(out) + 2 Na(+)(out) = D-xylose(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 73367

(R)-pantothenate(out) + 2 Na(+)(out) = (R)-pantothenate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 73371

biotin(out) + 2 Na(+)(out) = biotin(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 73375

(R)-lipoate(out) + 2 Na(+)(out) = (R)-lipoate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 73379

thiamine phosphate(out) + thiamine diphosphate(in) = thiamine phosphate(in) + thiamine diphosphate(out)

Direction not assertedBalancedTransportRhea 73383

malonate(out) + phosphate(in) + H(+)(in) = malonate(in) + phosphate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 73387

sulfate(out) + phosphate(in) + H(+)(in) = sulfate(in) + phosphate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 73391

L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 73395

D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 73399

(2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 73403

(S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 73407

sulfate(out) + succinate(in) = sulfate(in) + succinate(out)

Direction not assertedBalancedTransportRhea 73411

(-)-cyclopenine = viridicatin + methyl isocyanate + H(+)

Direction not assertedBalancedRhea 73415

L-glutamine(out) = L-glutamine(in)

ReversibleBalancedTransportRhea 73419

L-asparagine(out) = L-asparagine(in)

Direction not assertedBalancedTransportRhea 73423

genkwanin + reduced [NADPH--hemoprotein reductase] + O2 = scutellarein 7-methyl ether + oxidized [NADPH--hemoprotein reductase] + H2O

Direction not assertedBalance undeterminableRhea 73427

(2S)-sakuranetin + reduced [NADPH--hemoprotein reductase] + O2 = (2S)-7-methylcarthamidin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 73431

apigenin 4',7-dimethyl ether + reduced [NADPH--hemoprotein reductase] + O2 = ladanein + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 73435

(2S)-naringenin 4',7-dimethyl ether + reduced [NADPH--hemoprotein reductase] + O2 = (2S)-carthamidin-4',7-dimethyl ether + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 73439

gardenin B + 2-oxoglutarate + O2 = nevadensin + formaldehyde + succinate + CO2 + H(+)

Direction not assertedBalancedRhea 73443

acetyl-CoA(in) + AMP(out) = acetyl-CoA(out) + AMP(in)

Direction not assertedBalancedTransportRhea 73447

adenosine 3',5'-bisphosphate(in) + AMP(out) = adenosine 3',5'-bisphosphate(out) + AMP(in)

Direction not assertedBalancedTransportRhea 73451

salvigenin + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 8-hydroxysalvigenin + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 73455

protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin] + 2 O2 + 5 H(+) = protochlorophyllide b + 4 oxidized [2Fe-2S]-[ferredoxin] + 3 H2O

Direction not assertedBalance undeterminableRhea 73459

carcinine + H2O = histamine + beta-alanine

Direction not assertedBalancedRhea 73463

beta-alanyl-dopamine + H2O = dopamine + beta-alanine

Direction not assertedBalancedRhea 73467

D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

Direction not assertedBalancedTransportRhea 73471

D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

Direction not assertedBalancedTransportRhea 73475

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