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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
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Interactions
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Reactions
Reach

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Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,751–2,800 of 18,558 reactions from Rhea

an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
ReversibleBalance undeterminableRhea 21564
beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O = beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose
Direction not assertedBalancedRhea 21568
3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = N-acetylanthranilate + CO + H(+)
Direction not assertedBalancedRhea 21572
carnitine + H(+) = 2-methylcholine + CO2
Direction not assertedBalancedRhea 21576
(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2
Direction not assertedBalancedRhea 21580
propane-1,2-diol 1-phosphate + NAD(+) = hydroxyacetone phosphate + NADH + H(+)
Direction not assertedBalancedRhea 21584
N-acetyl-L-glutamate 5-semialdehyde + phosphate + NADP(+) = N-acetyl-L-glutamyl 5-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 21588

(2S)-2-[(R)-1-carboxyethylamino]pentanoate + NAD(+) + H2O = L-2-aminopentanoate + pyruvate + NADH + H(+)

Direction not assertedBalancedRhea 21592

L-serine + NADP(+) = 2-aminomalonate semialdehyde + NADPH + H(+)

Direction not assertedBalancedRhea 21596

anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA

Direction not assertedBalancedRhea 21600

styrene oxide = 2-phenylacetaldehyde

Direction not assertedBalancedRhea 21604

isoliquiritigenin + S-adenosyl-L-methionine = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 21608

D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O

Direction not assertedBalancedRhea 21612

a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)

Left to rightBalance undeterminableRhea 21616

FMNH2 + NAD(+) = FMN + NADH + 2 H(+)

Right to leftBalancedRhea 21620

FMNH2 + NADP(+) = FMN + NADPH + 2 H(+)

Right to leftBalancedRhea 21624

17alpha-hydroxyprogesterone + NADPH + O2 = androst-4-ene-3,17-dione + acetate + NADP(+) + H2O

Direction not assertedBalancedRhea 21628

2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O

Direction not assertedBalancedRhea 21632

(E)-4-coumarate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-coumarate + UDP + H(+)

Direction not assertedBalancedRhea 21636

prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH

Direction not assertedBalancedRhea 21640

glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)

Left to rightBalancedRhea 21644

prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O

Direction not assertedBalancedRhea 21648

2-chlorobenzoate + NADH + O2 + H(+) = catechol + chloride + CO2 + NAD(+)

Direction not assertedBalancedRhea 21652

CDP-alpha-D-paratose = CDP-3,6-dideoxy-alpha-D-mannose

Direction not assertedBalancedRhea 21656

benzaldehyde + NADP(+) + H2O = benzoate + NADPH + 2 H(+)

Left to rightBalancedRhea 21660

4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)

Direction not assertedBalancedRhea 21664

sn-glycerol 3-phosphate(out) + ATP + H2O = sn-glycerol 3-phosphate(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 21668

[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 21672

2 dimethylallyl diphosphate = (R)-lavandulyl diphosphate + diphosphate

Direction not assertedBalancedRhea 21676

(2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2

Direction not assertedBalancedRhea 21680

(R)-beta-alanopine + NAD(+) + H2O = beta-alanine + pyruvate + NADH + H(+)

Direction not assertedBalancedRhea 21684

a polyvinyl alcohol + n O2 = an oxidized polyvinyl alcohol + n H2O2

Direction not assertedBalance undeterminableRhea 21688

CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)

Direction not assertedBalancedRhea 21692

N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 21696

5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate

Direction not assertedBalancedRhea 21700

L-tyrosine + H2O = phenol + pyruvate + NH4(+)

Direction not assertedBalancedRhea 21704

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine

Left to rightBalancedRhea 21708

L-threo-3-phenylserine = benzaldehyde + glycine

Left to rightBalancedRhea 21712

(S)-mandelate + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = (S)-4-hydroxymandelate + (6R)-L-erythro-6,7-dihydrobiopterin + H2O

Direction not assertedBalancedRhea 21716

formamide = hydrogen cyanide + H2O

Direction not assertedBalancedRhea 21720

a nitrile + 2 H2O = a carboxylate + NH4(+)

Direction not assertedBalance undeterminableRhea 21724

GDP-alpha-D-mannose + 2 NAD(+) + H2O = GDP-alpha-D-mannuronate + 2 NADH + 3 H(+)

Direction not assertedBalancedRhea 21728

chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)

Direction not assertedBalancedRhea 21732

(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate

Direction not assertedBalancedRhea 21736

2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

Direction not assertedBalance undeterminableRhea 21740

S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalancedRhea 21744

(S)-lactaldehyde + NADP(+) = methylglyoxal + NADPH + H(+)

Direction not assertedBalancedRhea 21748

all-trans-violaxanthin = all-trans-capsorubin

Direction not assertedBalancedRhea 21752

deacetylisoipecoside + H2O = secologanin + dopamine

Direction not assertedBalancedRhea 21756

(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA

Direction not assertedBalancedRhea 21760

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