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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,701–2,750 of 18,558 reactions from Rhea

L-arabinitol + NAD(+) = L-ribulose + NADH + H(+)
Direction not assertedBalancedRhea 21356
beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)
ReversibleBalancedRhea 21360
N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate
Direction not assertedBalancedRhea 21364
urate + O2 + H2O = 5-hydroxyisourate + H2O2
Direction not assertedBalancedRhea 21368
urethane + H2O + H(+) = ethanol + NH4(+) + CO2
Direction not assertedBalancedRhea 21372
3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2
Left to rightBalancedRhea 21376
3,7,11,15-tetramethylhexadecanoate + ATP + CoA = phytanoyl-CoA + AMP + diphosphate

→ Left to right

Balanced

Rhea 21380

L-phenylalanine = (E)-cinnamate + NH4(+)

Direction not assertedBalancedRhea 21384

L-2-aminohexano-6-lactam + H2O = L-lysine

Direction not assertedBalancedRhea 21388

2-phenylacetaldehyde + NAD(+) + H2O = 2-phenylacetate + NADH + 2 H(+)

Direction not assertedBalancedRhea 21392

(S)-methylmalonyl-CoA + Na(+)(in) + H(+)(out) = propanoyl-CoA + Na(+)(out) + CO2

Direction not assertedBalancedTransportRhea 21396

chloride + O2 = chlorite

Direction not assertedBalancedRhea 21404

L-phenylalanine + NAD(+) + H2O = 3-phenylpyruvate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 21408

sn-glycerol 1-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)

Direction not assertedBalancedRhea 21412

sn-glycerol 1-phosphate + NADP(+) = dihydroxyacetone phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 21416

prostaglandin I2 + NADP(+) = 15-dehydro-prostaglandin I2 + NADPH + H(+)

Direction not assertedBalancedRhea 21420

3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H(+)

Direction not assertedBalancedRhea 21424

(2R)-3-sulfolactate = sulfite + pyruvate + H(+)

Direction not assertedBalancedRhea 21428

(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)

ReversibleBalancedRhea 21432

[translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+)

Direction not assertedBalance undeterminableRhea 21436

a long-chain fatty aldehyde + 2 NADPH + O2 + H(+) = a long-chain alkane + formate + 2 NADP(+) + H2O

Direction not assertedBalance undeterminableRhea 21440

3-(2-hydroxyphenyl)propanoate + NAD(+) = trans-2-coumarate + NADH + H(+)

Direction not assertedBalancedRhea 21444

N2 + 8 reduced [2Fe-2S]-[ferredoxin] + 16 ATP + 16 H2O = H2 + 8 oxidized [2Fe-2S]-[ferredoxin] + 2 NH4(+) + 16 ADP + 16 phosphate + 6 H(+)

Direction not assertedBalance undeterminableRhea 21448

a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Direction not assertedBalance undeterminableRhea 21452

(S)-tetrahydrocolumbamine + reduced [NADPH--hemoprotein reductase] + O2 = (S)-canadine + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 21456

benzoin = 2 benzaldehyde

Direction not assertedBalancedRhea 21460

thiocyanate + H2O + 2 H(+) = carbonyl sulfide + NH4(+)

Direction not assertedBalancedRhea 21464

tylactone + dTDP-alpha-D-mycaminose = 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)

Direction not assertedBalancedRhea 21468

citrate + ATP + CoA = (3S)-citryl-CoA + ADP + phosphate

Direction not assertedBalancedRhea 21472

[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-beta-D-glucosyl](n+1) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 21476

2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH2 + H(+)

Direction not assertedBalancedRhea 21480

dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = dalnigrein + beta-D-apiofuranosyl-(1->6)-D-glucopyranose + H(+)

Direction not assertedBalancedRhea 21488

2,3-dihydroxybenzoate + H(+) = catechol + CO2

Direction not assertedBalancedRhea 21492

dimethylallyl diphosphate + H2O = prenol + diphosphate

Direction not assertedBalancedRhea 21496

UDP-alpha-D-glucose = UDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O

Left to rightBalancedRhea 21500

aldehydo-D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde

Direction not assertedBalancedRhea 21504

all-trans-retinyl hexadecanoate + H2O = retinol + hexadecanoate + H(+)

Direction not assertedBalancedRhea 21508

3,6-anhydro-L-galactonate = 2-dehydro-3-deoxy-L-galactonate

Direction not assertedBalancedRhea 21512

isopiperitenone = piperitenone

Direction not assertedBalancedRhea 21516

2 Fe(III)-[cytochrome b1] + formate = 2 Fe(II)-[cytochrome b1] + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 21520

3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)

Direction not assertedBalancedRhea 21524

[phosphate](n) + H2O = [phosphate](n-1) + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 21528

glutathionylspermidine + glutathione + ATP = trypanothione + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 21532

(3S)-3-hydroxy-3-methylglutaryl-CoA = 3-methyl-(2E)-glutaconyl-CoA + H2O

Right to leftBalancedRhea 21536

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Direction not assertedBalancedRhea 21540

(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP

Left to rightBalancedRhea 21544

N(6)-acetyl-L-lysyl-[alpha-tubulin] + H2O = L-lysyl-[alpha-tubulin] + acetate

Left to rightBalance undeterminableRhea 21548

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP + H(+)

Direction not assertedBalance undeterminableRhea 21552

[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 21556

3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 1,4-dithiothreitol + 2,3-epoxyphylloquinone

Direction not assertedBalancedRhea 21560

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