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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,651–2,700 of 18,558 reactions from Rhea

inosine + ATP = IMP + ADP + H(+)
Direction not assertedBalancedRhea 21140
5-methyl-5,6,7,8-tetrahydromethanopterin + oxidized coenzyme F420-(gamma-L-Glu)(n) + H(+) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)
Direction not assertedBalance undeterminableRhea 21144
indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + UDP + H(+)
Direction not assertedBalancedRhea 21148
trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline
Direction not assertedBalancedRhea 21152
(2R)-2-phosphoglycerate + H2O = (R)-glycerate + phosphate
Direction not assertedBalancedRhea 21156
oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA
Right to leftBalancedRhea 21160
a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)

Direction not assertedBalance undeterminableRhea 21164

L-idonate + NAD(+) = 5-dehydro-D-gluconate + NADH + H(+)

Direction not assertedBalancedRhea 21172

L-idonate + NADP(+) = 5-dehydro-D-gluconate + NADPH + H(+)

Direction not assertedBalancedRhea 21176

1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = indole-3-acetyl-1D-myo-inositol + D-glucose

Direction not assertedBalancedRhea 21180

a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP

Left to rightBalance undeterminableRhea 21184

deamido-NAD(+) + NH4(+) + ATP = AMP + diphosphate + NAD(+) + H(+)

Direction not assertedBalancedRhea 21188

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine

Direction not assertedBalancedRhea 21196

L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate

Direction not assertedBalancedRhea 21200

a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

Direction not assertedBalance undeterminableRhea 21204

O-phospho-L-serine + H2O = L-serine + phosphate

Left to rightBalancedRhea 21208

N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] + H2O = 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate

Direction not assertedBalance undeterminableRhea 21212

D-ribose 5-phosphate + ATP = alpha-D-ribose 1,5-bisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 21216

L-dopa + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)

Direction not assertedBalancedRhea 21220

CDP-choline + sphing-4-enine = sphing-4-enine-phosphocholine + CMP + H(+)

Direction not assertedBalancedRhea 21224

alpha-maltose = beta-maltose

Direction not assertedBalancedRhea 21228

L-histidine = trans-urocanate + NH4(+)

Direction not assertedBalancedRhea 21232

anthranilate + NADPH + O2 + 2 H(+) = 2,3-dihydroxybenzoate + NH4(+) + NADP(+)

Direction not assertedBalancedRhea 21236

geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate

Direction not assertedBalance undeterminableRhea 21240

an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine = an 8-methoxyfurocoumarin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 21244

RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate

ReversibleBalance undeterminableRhea 21248

(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

Direction not assertedBalancedRhea 21252

3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate

Direction not assertedBalancedRhea 21256

[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

Direction not assertedBalance undeterminableRhea 21260

glycolate + A = glyoxylate + AH2

Direction not assertedBalancedRhea 21264

(R)-canadine + 2 NADP(+) = berberine + 2 NADPH + H(+)

Direction not assertedBalancedRhea 21268

spermidine + glutathione + ATP = glutathionylspermidine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 21272

D-arabinitol + NADP(+) = D-xylulose + NADPH + H(+)

Direction not assertedBalancedRhea 21276

thiamine + 2 O2 + H2O = thiamine acetate + 2 H2O2 + H(+)

Direction not assertedBalancedRhea 21280

all-trans-retinol + NAD(+) = all-trans-retinal + NADH + H(+)

Left to rightBalancedRhea 21284

sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol

Direction not assertedBalancedRhea 21288

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)

Left to rightBalance undeterminableRhea 21292

D-galactose + NAD(+) = D-galactono-1,4-lactone + NADH + H(+)

Direction not assertedBalancedRhea 21296

an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + H2O = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + sulfate + H(+)

Left to rightBalance undeterminableRhea 21300

ent-kaur-16-en-19-ol + reduced [NADPH--hemoprotein reductase] + O2 = ent-kaur-16-en-19-al + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 21304

(S)-2,3-epoxysqualene = cycloartenol

Direction not assertedBalancedRhea 21308

2,5-dihydroxybenzoate + H(+) = hydroquinone + CO2

Direction not assertedBalancedRhea 21312

phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate + H(+)

Direction not assertedBalancedRhea 21316

D-sorbitol + A = keto-L-sorbose + AH2

Direction not assertedBalancedRhea 21320

reduced [rubredoxin] + superoxide + 2 H(+) = oxidized [rubredoxin] + H2O2

Direction not assertedBalance undeterminableRhea 21324

D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H(+)

Direction not assertedBalancedRhea 21332

pyridoxal + NAD(+) = 4-pyridoxolactone + NADH + H(+)

Direction not assertedBalancedRhea 21336

1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin

Direction not assertedBalancedRhea 21340

10 malonyl-CoA + 8 H(+) = tetracenomycin F2 + 10 CO2 + 10 CoA + 2 H2O

Direction not assertedBalancedRhea 21348

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)

Direction not assertedBalancedRhea 21352

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