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CompoundsSubstances with curated findings
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ReactionsRhea and Human-GEM, by subsystem
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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

26,151–26,200 of 31,435, by identifier

a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine
Direction not assertedBalance undeterminableRhea 65440
hexan-1-ol + butanoyl-CoA = hexyl butanoate + CoA
Direction not assertedBalancedRhea 65444
ethanol + butanoyl-CoA = ethyl butanoate + CoA
Direction not assertedBalancedRhea 65448
hexanoyl-CoA + ethanol = ethyl hexanoate + CoA
Direction not assertedBalancedRhea 65452
2-methylbutan-1-ol + acetyl-CoA = 2-methylbutyl acetate + CoA
Direction not assertedBalancedRhea 65456
hexan-1-ol + acetyl-CoA = hexyl acetate + CoA
Direction not assertedBalancedRhea 65460
2-methylbutan-1-ol + butanoyl-CoA = 2-methylbutyl butanoate + CoA

Direction not assertedBalancedRhea 65464

1-propanol + acetyl-CoA = propyl acetate + CoA

Direction not assertedBalancedRhea 65468

2-methylbutanoyl-CoA + ethanol = ethyl 2-methylbutanoate + CoA

Direction not assertedBalancedRhea 65472

1-propanol + butanoyl-CoA = propyl butanoate + CoA

Direction not assertedBalancedRhea 65476

2-methylbutanoyl-CoA + hexan-1-ol = hexyl 2-methylbutanoate + CoA

Direction not assertedBalancedRhea 65480

hexan-1-ol + hexanoyl-CoA = hexyl hexanoate + CoA

Direction not assertedBalancedRhea 65484

3 ATP = 2',3',3'-c-tri-AMP + 3 diphosphate

Direction not assertedBalancedRhea 65488

[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + 5'-deoxyadenosine + L-methionine + CO2

Direction not assertedBalance undeterminableRhea 65492

3beta-hydroxy-5beta-pregnane-20-one + NADPH + H(+) = 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)

Left to rightBalancedRhea 65496

[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine = [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + 5'-deoxyadenosine + L-methionine + A + H(+)

Direction not assertedBalance undeterminableRhea 65500

[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O = [mycofactocin precursor peptide]-C-terminal glycine + 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one

Direction not assertedBalance undeterminableRhea 65504

3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 + H2O = pre-mycofactocin + H2O2 + NH4(+)

Direction not assertedBalancedRhea 65508

3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 = 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H2O2 + H(+)

Direction not assertedBalancedRhea 65512

5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H2O + H(+) = pre-mycofactocin + NH4(+)

Direction not assertedBalancedRhea 65516

all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 65520

9-cis-retinal + reduced [NADPH--hemoprotein reductase] + O2 = 9-cis-retinoate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 65524

hexan-1-ol + octanoyl-CoA = hexyl octanoate + CoA

Direction not assertedBalancedRhea 65528

2-methylbutan-1-ol + hexanoyl-CoA = 2-methylbutyl hexanoate + CoA

Direction not assertedBalancedRhea 65532

1,3,7-trimethylurate + S-adenosyl-L-methionine = theacrine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 65536

a ganglioside GM3 + H2O = N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose + an N-acyl-sphingoid base

Direction not assertedBalance undeterminableRhea 65540

a ganglioside GM1 + H2O = beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc + an N-acyl-sphingoid base

Direction not assertedBalance undeterminableRhea 65544

a ganglioside Fuc-GM1 + H2O = alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base

Direction not assertedBalance undeterminableRhea 65548

a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = lactose + an N-acyl-sphingoid base

Direction not assertedBalance undeterminableRhea 65552

a globoside GalGb4Cer + H2O = beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc + an N-acyl-sphingoid base

Direction not assertedBalance undeterminableRhea 65556

L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O

Left to rightBalancedRhea 65560

(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Left to rightBalancedRhea 65564

(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Left to rightBalancedRhea 65568

(-)-deoxypodophyllotoxin + reduced [NADPH--hemoprotein reductase] + O2 = (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 65572

a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate = an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP + H(+)

Direction not assertedBalance undeterminableRhea 65576

5-methyl-UTP + H2O = 5-methyl-UDP + phosphate + H(+)

Left to rightBalancedRhea 65580

(-)-casbene + reduced [NADPH--hemoprotein reductase] + O2 = 8-hydroxycasbene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 65584

(-)-casbene + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxycasbene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 65588

8-hydroxycasbene + reduced [NADPH--hemoprotein reductase] + O2 = 4,8-dihydroxycasbene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 65592

4-hydroxycasbene + reduced [NADPH--hemoprotein reductase] + O2 = 4,8-dihydroxycasbene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 65596

4,5,8-trihydroxycasbene + 2 NAD(+) = jolkinol C + 2 NADH + 2 H(+)

Direction not assertedBalancedRhea 65600

(4R)-hydroxysphinganine + eicosanoyl-CoA = N-eicosanoyl-(4R)-hydroxysphinganine + CoA + H(+)

Direction not assertedBalancedRhea 65604

docosanoyl-CoA + (4R)-hydroxysphinganine = N-docosanoyl-(4R)-hydroxysphinganine + CoA + H(+)

Direction not assertedBalancedRhea 65608

a C21-steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C21-steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 65612

cholest-4-en-3-one + A + H2O = 25-hydroxycholest-4-en-3-one + AH2

Direction not assertedBalancedRhea 65616

sphinga-(4E,8E)-dienine + hexadecanoyl-CoA = N-hexadecanoylsphinga-(4E,8E)-dienine + CoA + H(+)

Direction not assertedBalancedRhea 65620

sphinga-(4E,8Z)-dienine + hexadecanoyl-CoA = N-hexadecanoylsphinga-(4E,8Z)-dienine + CoA + H(+)

Direction not assertedBalancedRhea 65624

sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA = N-tetracosanoylsphinga-(4E,8Z)-dienine + CoA + H(+)

Direction not assertedBalancedRhea 65628

a sphingoid base + tetracosanoyl-CoA = an N-tetracosanoyl-sphingoid base + CoA + H(+)

Direction not assertedBalance undeterminableRhea 65632

sphinga-(4E,8E)-dienine + tetracosanoyl-CoA = N-tetracosanoylsphinga-(4E,8E)-dienine + CoA + H(+)

Direction not assertedBalancedRhea 65636

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