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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,551–2,600 of 18,558 reactions from Rhea

erythritol + ATP = D-erythritol 4-phosphate + ADP + H(+)
Direction not assertedBalancedRhea 20708
6-carboxyhexanoyl-CoA + L-alanine + H(+) = (8S)-8-amino-7-oxononanoate + CO2 + CoA
Direction not assertedBalancedRhea 20712
S-adenosyl-L-homocysteine + H2O + H(+) = S-inosyl-L-homocysteine + NH4(+)
Direction not assertedBalancedRhea 20716
isopenicillin N + phenylacetyl-CoA + H2O = penicillin G + L-2-aminoadipate + CoA + H(+)
Direction not assertedBalancedRhea 20720
a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O
Left to rightBalance undeterminableRhea 20724
L-glutamate + O2 + H2O = 2-oxoglutarate + H2O2 + NH4(+)
Direction not assertedBalancedRhea 20728
[protein]-dithiol + [thioredoxin]-disulfide = [protein]-disulfide + [thioredoxin]-dithiol

Direction not assertedBalance undeterminableRhea 20732

glycine + acetyl-CoA = (2S)-2-amino-3-oxobutanoate + CoA

Right to leftBalancedRhea 20736

trans-2,3-epoxysuccinate + H2O = (2R,3S)-tartrate

Direction not assertedBalancedRhea 20740

prostaglandin D2 + NADP(+) = 15-oxoprostaglandin D2 + NADPH + H(+)

Left to rightBalancedRhea 20744

penicillin N + 2-oxoglutarate + O2 = deacetoxycephalosporin C + succinate + CO2 + H2O

Direction not assertedBalancedRhea 20748

2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

Right to leftBalancedRhea 20752

D-threo-isocitrate + (E)-caffeoyl-CoA = 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA

Direction not assertedBalancedRhea 20756

(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate

Direction not assertedBalancedRhea 20764

3-phosphonopyruvate + H(+) = phosphonoacetaldehyde + CO2

Direction not assertedBalancedRhea 20768

2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin

Direction not assertedBalancedRhea 20772

alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose = stachyose + myo-inositol

Direction not assertedBalancedRhea 20776

GMP + ATP = GDP + ADP

Direction not assertedBalancedRhea 20780

N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine

Direction not assertedBalancedRhea 20784

phosphate + NAD(+) = ADP-alpha-D-ribose 1''-phosphate + nicotinamide + H(+)

Direction not assertedBalancedRhea 20788

tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate

Direction not assertedBalancedRhea 20792

aldehydo-D-ribose = D-ribulose

Direction not assertedBalancedRhea 20796

3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 20800

2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)

Left to rightBalancedRhea 20804

(3S)-citryl-CoA = oxaloacetate + acetyl-CoA

Direction not assertedBalancedRhea 20812

3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + NADPH + H(+)

Direction not assertedBalancedRhea 20816

choline sulfate + H2O = choline + sulfate + H(+)

Direction not assertedBalancedRhea 20820

adenosine + ATP = AMP + ADP + H(+)

Left to rightBalancedRhea 20824

a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2

Left to rightBalance undeterminableRhea 20828

guanine(out) + ATP + H2O = guanine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 20832

L-histidine + H(+) = histamine + CO2

Direction not assertedBalancedRhea 20840

hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)

Left to rightBalancedRhea 20844

pyruvate + phosphate + O2 + H(+) = acetyl phosphate + H2O2 + CO2

Direction not assertedBalancedRhea 20848

ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)

Direction not assertedBalancedTransportRhea 20852

an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid

Left to rightBalance undeterminableRhea 20856

(1S,6R)-isopiperitenol + NAD(+) = (6R)-isopiperitenone + NADH + H(+)

Direction not assertedBalancedRhea 20860

alpha,alpha-trehalose 6-phosphate + phosphate = beta-D-glucose 1-phosphate + D-glucose 6-phosphate

Direction not assertedBalancedRhea 20864

(20S)-ginsenoside Rd + UDP-alpha-D-glucose = (20S)-ginsenoside Rb1 + UDP + H(+)

Direction not assertedBalancedRhea 20872

(R)-2-benzylsuccinyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]

Direction not assertedBalance undeterminableRhea 20876

10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + NADH + H(+)

Left to rightBalancedRhea 20880

L-serine + NAD(+) + H2O = 3-hydroxypyruvate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 20884

3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)

Direction not assertedBalancedRhea 20888

butanoyl-CoA + phosphate = butanoyl phosphate + CoA

Direction not assertedBalancedRhea 20892

urea + hydrogencarbonate + ATP = urea-1-carboxylate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 20896

N-benzyloxycarbonylglycine + H2O + H(+) = benzyl alcohol + glycine + CO2

Direction not assertedBalancedRhea 20900

(S)-2-hydroxypropyl-coenzyme M = (S)-1,2-epoxypropane + coenzyme M

Direction not assertedBalancedRhea 20904

3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 20908

(2E,6E,10E)-geranylgeranyl diphosphate = taxa-4(5),11(12)-diene + diphosphate

Direction not assertedBalancedRhea 20912

sulfite + L-cysteine = L-cysteate + hydrogen sulfide

Direction not assertedBalancedRhea 20916

2,4-dichlorophenol + NADPH + O2 + H(+) = 3,5-dichlorocatechol + NADP(+) + H2O

Direction not assertedBalancedRhea 20920

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