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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

25,751–25,800 of 31,435, by identifier

vanillin + L-alanine = vanillylamine + pyruvate
Direction not assertedBalancedRhea 63828
vanillylamine + (6E)-8-methylnon-6-enoyl-CoA = capsaicin + CoA + H(+)
Direction not assertedBalancedRhea 63832
hexadecanoate + O2 = (2R)-2-hydroperoxyhexadecanoate
Direction not assertedBalancedRhea 63836
tert-butyl hydroperoxide + [thioredoxin]-dithiol = tert-butanol + [thioredoxin]-disulfide + H2O
Direction not assertedBalance undeterminableRhea 63840
cumene hydroperoxide + [thioredoxin]-dithiol = 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O
Direction not assertedBalance undeterminableRhea 63844
2 2',3,4-trihydroxy-trans-chalcone + O2 + 2 H(+) = 2 3',4'-dihydroxyaurone + 2 H2O
Direction not assertedBalancedRhea 63848
dodecanoate + O2 = (2R)-2-hydroperoxydodecanoate

Direction not assertedBalancedRhea 63852

tetradecanoate + O2 = (2R)-2-hydroperoxytetradecanoate

Direction not assertedBalancedRhea 63856

(9Z,12Z)-octadecadienoate + O2 = (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate

Direction not assertedBalancedRhea 63860

octadecanoate + O2 = (2R)-2-hydroperoxyoctadecanoate

Direction not assertedBalancedRhea 63864

(9Z)-octadecenoate + O2 = (2R,9Z)-2-hydroperoxyoctadecenoate

Direction not assertedBalancedRhea 63868

L-isoleucine + 2-oxoglutarate + O2 = 3(1)-hydroxy-L-isoleucine + succinate + CO2

Direction not assertedBalancedRhea 63872

3(1)-hydroxy-L-isoleucine + 2-oxoglutarate + O2 = (4S)-3(1),4-dihydroxy-L-isoleucine + succinate + CO2

Direction not assertedBalancedRhea 63876

thiocyanate + 2 Fe(III)-[cytochrome c] + H2O = cyanate + sulfur + 2 Fe(II)-[cytochrome c] + 2 H(+)

Direction not assertedBalance undeterminableRhea 63880

L-tyrosine + H2O2 = L-dopa + H2O

Direction not assertedBalancedRhea 63884

sphinga-4E,14Z-dienine + hexadecanoyl-CoA = N-hexadecanoyl-sphinga-4E,14Z-dienine + CoA + H(+)

Left to rightBalancedRhea 63888

L-tryptophan + ATP + H2O = D-tryptophan + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 63892

aspulvinone E + hnu = isoaspulvinone E

Direction not assertedBalance undeterminableRhea 63896

2 3-(4-hydroxyphenyl)pyruvate + 2 ATP + H2O = (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + 2 AMP + 2 diphosphate + H(+)

Direction not assertedBalancedRhea 63900

2 3-phenylpyruvate + 2 ATP + H2O = phenguignardate + 2 AMP + 2 diphosphate + H(+)

Direction not assertedBalancedRhea 63904

pravastatin(in) + ATP + H2O = pravastatin(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 63908

6-azauridine + ATP = 6-azauridine 5'-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 63912

5-fluorouridine + ATP = 5-fluorouridine 5'-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 63916

sphinga-4E,14Z-dienine + octadecanoyl-CoA = N-octadecanoyl-sphinga-4E,14Z-dienine + CoA + H(+)

Direction not assertedBalancedRhea 63920

N(4)-acetylcytidine + ATP = N(4)-acetylcytidine 5'-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 63924

an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O

Left to rightBalance undeterminableRhea 63928

abscisate(in) + ATP + H2O = abscisate(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 63932

protoporphyrinogen IX + 3 a ubiquinone = protoporphyrin IX + 3 a ubiquinol

Direction not assertedBalance undeterminableRhea 63936

N-(hexanoyl)sphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = N-hexanoyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O

Left to rightBalance undeterminableRhea 63940

sphinga-4E,14Z-dienine + a fatty acyl-CoA = an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)

Direction not assertedBalance undeterminableRhea 63944

sphinga-4E,14Z-dienine-1-phosphate + H2O = sphinga-4E,14Z-dienine + phosphate

Direction not assertedBalancedRhea 63948

a sphingoid 1-phosphate + H2O = a sphingoid base + phosphate

Direction not assertedBalance undeterminableRhea 63952

sphinga-4E,14Z-dienine + ATP = sphinga-4E,14Z-dienine-1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 63956

abscisate(out) + ATP + H2O = abscisate(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 63960

sphinga-4E,14Z-dienine-1-phosphate = (2E,12Z)-hexadecadienal + phosphoethanolamine

Direction not assertedBalancedRhea 63964

2 3-(4-hydroxyphenyl)pyruvate + 2 ATP = atromentin + 2 AMP + 2 diphosphate + H(+)

Direction not assertedBalancedRhea 63968

dihydropyriculol + A = pyriculol + AH2

Direction not assertedBalancedRhea 63972

dihydropyriculariol + A = pyriculariol + AH2

Direction not assertedBalancedRhea 63976

4-thiouridine + ATP = 4-thiouridine 5'-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 63980

5-hydroxyuridine + ATP = 5-hydroxyuridine 5'-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 63984

2-thiocytidine + ATP = 2-thiocytidine 5'-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 63988

5-fluorocytidine + ATP = 5-fluorocytidine 5'-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 63992

1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoate + H(+)

Left to rightBalancedRhea 63996

(4R)-hydroxysphinganine + octadecanoyl-CoA = N-octadecanoyl-(4R)-hydroxysphinganine + CoA + H(+)

Direction not assertedBalancedRhea 64000

(4R)-hydroxysphinganine + hexadecanoyl-CoA = N-hexadecanoyl-(4R)-hydroxysphinganine + CoA + H(+)

Left to rightBalancedRhea 64008

3 malonyl-CoA + acetyl-CoA + AH2 + 3 S-adenosyl-L-methionine = fumigermin + A + 3 S-adenosyl-L-homocysteine + 3 CO2 + 4 CoA + H2O

Direction not assertedBalancedRhea 64012

alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc + GDP + H(+)

Left to rightBalancedRhea 64016

L-seryl-[protein] + GTP = O-phospho-L-seryl-[protein] + GDP + H(+)

Left to rightBalance undeterminableRhea 64020

N(8),N'(8)-citryl-bis(spermidine) + 3,4-dihydroxybenzoyl-[aryl-carrier protein] = N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) + holo-[aryl-carrier protein] + H(+)

Direction not assertedBalance undeterminableRhea 64024

N(8)-citryl-spermidine + 3,4-dihydroxybenzoyl-[aryl-carrier protein] = N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + holo-[aryl-carrier protein] + H(+)

Direction not assertedBalance undeterminableRhea 64028

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