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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,501–2,550 of 18,558 reactions from Rhea

an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)
Direction not assertedBalance undeterminableRhea 20493
a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+)
Direction not assertedBalance undeterminableRhea 20497
an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid
Left to rightBalance undeterminableRhea 20505
viomycin + ATP = O-phosphoviomycin + ADP + H(+)
Direction not assertedBalancedRhea 20509
2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO2
Direction not assertedBalance undeterminableRhea 20513
UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine
Direction not assertedBalancedRhea 20517

(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+)

Direction not assertedBalancedRhea 20521

ethylamine + L-glutamate + ATP = N(5)-ethyl-L-glutamine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 20525

2-cis-(+)-abscisic aldehyde + O2 + H2O = 2-cis-(+)-abscisate + H2O2 + H(+)

Direction not assertedBalancedRhea 20529

pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate

Left to rightBalancedRhea 20533

holo-[ACP] + H2O = apo-[ACP] + (R)-4'-phosphopantetheine + H(+)

Direction not assertedBalance undeterminableRhea 20537

Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 + H(+) = Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 20541

L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O

Direction not assertedBalancedRhea 20545

2 thiosulfate + 2 Fe(III)-[cytochrome c] = tetrathionate + 2 Fe(II)-[cytochrome c] + 2 H(+)

Direction not assertedBalance undeterminableRhea 20549

(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA

Right to leftBalancedRhea 20553

urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)

Direction not assertedBalancedRhea 20557

3-hydroxypyruvate + H(+) = glycolaldehyde + CO2

Direction not assertedBalancedRhea 20561

(2E)-geranyl diphosphate + H2O = (1S,2S,4R)-endo-fenchol + diphosphate

Direction not assertedBalancedRhea 20565

L-arginine + H2O = urea + L-ornithine

Left to rightBalancedRhea 20569

calcidiol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = calcitriol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 20573

3-hydroxyaminophenol = aminohydroquinone

Direction not assertedBalancedRhea 20577

NH4(+) + NAD(+) + H2O = hydroxylamine + NADH + 2 H(+)

Direction not assertedBalancedRhea 20581

loganin + reduced [NADPH--hemoprotein reductase] + O2 = secologanin + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 20585

glutaryl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]

Direction not assertedBalance undeterminableRhea 20589

N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate

Direction not assertedBalancedRhea 20593

2 L-cysteine + NAD(+) = L-cystine + NADH + H(+)

Direction not assertedBalancedRhea 20597

cytosine + H2O + H(+) = uracil + NH4(+)

Direction not assertedBalancedRhea 20605

2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate

Direction not assertedBalancedRhea 20609

a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + 3'-phosphoadenylyl sulfate = an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 20613

L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 + H(+)

Direction not assertedBalancedRhea 20617

Zn(2+)(in) + ATP + H2O = Zn(2+)(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 20621

2 Fe(III)-[cytochrome c3] + H2 = 2 Fe(II)-[cytochrome c3] + 2 H(+)

Direction not assertedBalance undeterminableRhea 20625

O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate

Left to rightBalance undeterminableRhea 20629

a (3R)-hydroxyacyl-[ACP] + L-ornithine = a lyso-ornithine lipid + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 20633

D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol

Direction not assertedBalancedRhea 20637

L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)

Direction not assertedBalancedRhea 20641

23,24-dihydrocucurbitacin B + NADP(+) = cucurbitacin B + NADPH + H(+)

Direction not assertedBalancedRhea 20649

23,24-dihydrocucurbitacin B + NAD(+) = cucurbitacin B + NADH + H(+)

Direction not assertedBalancedRhea 20653

4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH4(+)

Direction not assertedBalancedRhea 20657

D-alanyl-D-alanine + H2O = 2 D-alanine

Direction not assertedBalancedRhea 20661

1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + NADPH + H(+)

Direction not assertedBalancedRhea 20665

4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH

Direction not assertedBalancedRhea 20669

4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH

Direction not assertedBalancedRhea 20673

alizarin + UDP-alpha-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + UDP + H(+)

Direction not assertedBalancedRhea 20677

cis-zeatin + UDP-alpha-D-glucose = O-beta-D-glucosyl-cis-zeatin + UDP + H(+)

Direction not assertedBalancedRhea 20681

galactitol + NAD(+) = keto-D-tagatose + NADH + H(+)

Direction not assertedBalancedRhea 20685

chlorogenate + H2O = L-quinate + (E)-caffeate + H(+)

Direction not assertedBalancedRhea 20689

2 superoxide + 2 H(+) = H2O2 + O2

Left to rightBalancedRhea 20696

lipid A disaccharide (E. coli) + ATP = lipid IVA (E. coli) + ADP + H(+)

Direction not assertedBalancedRhea 20700

a D-alpha-amino acid + acetyl-CoA = an N-acetyl-D-amino acid + CoA + H(+)

Direction not assertedBalance undeterminableRhea 20704

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