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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
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Interactions
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Chemistry

Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,451–2,500 of 18,558 reactions from Rhea

acetyl-CoA + H2O = acetate + CoA + H(+)
Left to rightBalancedRhea 20289
3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH + H(+)
Direction not assertedBalancedRhea 20293
an anilide + H2O = aniline + a carboxylate + H(+)
Direction not assertedBalance undeterminableRhea 20297
tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate
Direction not assertedBalancedRhea 20301
4-hydroxybenzaldehyde + NAD(+) + H2O = 4-hydroxybenzoate + NADH + 2 H(+)
Direction not assertedBalancedRhea 20305
2 H2O2 = O2 + 2 H2O
Direction not assertedBalancedRhea 20309
1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 20313

L-proline + NADP(+) = 1-pyrroline-2-carboxylate + NADPH + H(+)

Right to leftBalancedRhea 20317

L-proline + NAD(+) = 1-pyrroline-2-carboxylate + NADH + H(+)

Right to leftBalancedRhea 20321

N-hydroxy-4-acetylaminobiphenyl = N-acetoxy-4-aminobiphenyl

Direction not assertedBalancedRhea 20325

L-seryl-[low-density-lipoprotein receptor] + ATP = O-phospho-L-seryl-[low-density-lipoprotein receptor] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 20329

L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 20333

(R)-2-O-sulfolactate + H2O = (R)-lactate + sulfate + H(+)

Direction not assertedBalancedRhea 20337

sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + UDP + H(+)

Direction not assertedBalancedRhea 20341

[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)

Right to leftBalance undeterminableRhea 20345

toluene + NADH + O2 + H(+) = 2-hydroxytoluene + NAD(+) + H2O

Direction not assertedBalancedRhea 20349

trichloroethene + chloride + A + H(+) = tetrachloroethene + AH2

Direction not assertedBalancedRhea 20353

3-phenylpropanoate + NADH + O2 + H(+) = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)

Direction not assertedBalancedRhea 20357

4-hydroxy-3-(all-trans-hexaprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 3,4-dihydroxy-5-(all-trans-hexaprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 20361

phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 20365

betaine aldehyde + O2 + H2O = glycine betaine + H2O2 + H(+)

Direction not assertedBalancedRhea 20369

propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 20373

androsterone + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)

Right to leftBalancedRhea 20377

androsterone + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)

ReversibleBalancedRhea 20381

(2R,3R)-dihydroquercetin + NADH + O2 + H(+) = (2R,3R)-2,3-dihydrogossypetin + NAD(+) + H2O

Direction not assertedBalancedRhea 20385

(2R,3R)-dihydroquercetin + NADPH + O2 + H(+) = (2R,3R)-2,3-dihydrogossypetin + NADP(+) + H2O

Direction not assertedBalancedRhea 20389

S-acetylphosphopantotheine + holo-[citrate lyase ACP] = acetyl-[citrate lyase ACP] + (R)-4'-phosphopantetheine

Direction not assertedBalance undeterminableRhea 20393

O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)

Direction not assertedBalancedRhea 20397

a beta-lactam + H2O = a substituted beta-amino acid

Direction not assertedBalance undeterminableRhea 20401

N-acetyl-(2S,6S)-2,6-diaminopimelate + H2O = (2S,6S)-2,6-diaminopimelate + acetate

Direction not assertedBalancedRhea 20405

riboflavin + alpha-D-glucose 1-phosphate = FMN + D-glucose

Direction not assertedBalancedRhea 20409

glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine = glucuronoxylan 4-O-methyl-D-glucuronate + n S-adenosyl-L-homocysteine + n H(+)

Direction not assertedBalance undeterminableRhea 20413

coelenterazine + O2 = coelenteramide + hnu + CO2

Direction not assertedBalance undeterminableRhea 20417

alpha-maltose 6'-phosphate + H2O = D-glucose 6-phosphate + D-glucose

Direction not assertedBalancedRhea 20421

hydrogencarbonate + 2-oxoglutarate + ATP = (S)-oxalosuccinate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 20425

apigenin + S-adenosyl-L-methionine = acacetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 20429

xylitol + NAD(+) = D-xylulose + NADH + H(+)

Direction not assertedBalancedRhea 20433

5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH + H(+)

Direction not assertedBalancedRhea 20437

L-cysteine + O2 = 3-sulfino-L-alanine + H(+)

Left to rightBalancedRhea 20441

L-arogenate + oxaloacetate = prephenate + L-aspartate

Direction not assertedBalancedRhea 20445

5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)

Direction not assertedBalancedRhea 20449

scopoletin + UDP-alpha-D-glucose = scopolin + UDP + H(+)

Direction not assertedBalancedRhea 20453

D-arabinose + NAD(+) = D-arabinono-1,4-lactone + NADH + H(+)

Direction not assertedBalancedRhea 20457

an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + 3 S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalance undeterminableRhea 20461

[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP + H(+)

Left to rightBalance undeterminableRhea 20465

IMP + H2O = hypoxanthine + D-ribose 5-phosphate

Direction not assertedBalancedRhea 20469

(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)

Direction not assertedBalance undeterminableRhea 20473

coelenterazine h + 3'-phosphoadenylyl sulfate = luciferyl sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 20481

(S)-scoulerine + reduced [NADPH--hemoprotein reductase] + O2 = (S)-cheilanthifoline + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 20485

L-alanyl-tRNA(Ala) + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)

Direction not assertedBalance undeterminableRhea 20489

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