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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,401–2,450 of 18,558 reactions from Rhea

guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+)
Left to rightBalancedRhea 20077
N-methylhexanamide + H2O = hexanoate + methylamine
Direction not assertedBalancedRhea 20081
a flavonol 3-O-beta-D-glucoside + malonyl-CoA = a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA
Direction not assertedBalance undeterminableRhea 20085
L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H(+)
Direction not assertedBalancedRhea 20089
an anthocyanidin + UDP-alpha-D-glucose + H(+) = an anthocyanidin 3-O-beta-D-glucoside + UDP
Direction not assertedBalance undeterminableRhea 20093
D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O
Direction not assertedBalancedRhea 20097
a long-chain fatty acid + L-cysteinyl-[protein] + ATP = an S-(long-chain fatty acyl)-L-cysteinyl-[protein] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 20101

beta-D-fructose 6-phosphate + ADP = beta-D-fructose 1,6-bisphosphate + AMP + H(+)

Direction not assertedBalancedRhea 20105

alpha-D-ribose 1,5-bisphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP

Direction not assertedBalancedRhea 20109

beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate

Direction not assertedBalancedRhea 20113

L-rhamnulose + ATP = L-rhamnulose 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 20117

tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate

Direction not assertedBalancedRhea 20121

2 reduced [2Fe-2S]-[ferredoxin] + NADP(+) + H(+) = 2 oxidized [2Fe-2S]-[ferredoxin] + NADPH

Direction not assertedBalance undeterminableRhea 20125

AMP + H2O = D-ribose 5-phosphate + adenine

Direction not assertedBalancedRhea 20129

3-(indol-3-yl)lactate + NAD(+) = indole-3-pyruvate + NADH + H(+)

Direction not assertedBalancedRhea 20133

10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA

Direction not assertedBalancedRhea 20137

an S-alkyl-L-cysteine S-oxide = an S-alkyl sulfenate + 2-aminoprop-2-enoate

Direction not assertedBalance undeterminableRhea 20141

quinine + reduced [NADPH--hemoprotein reductase] + O2 = 3-hydroxyquinine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 20149

L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 20153

a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] = an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)

Direction not assertedBalance undeterminableRhea 20157

alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose = raffinose + myo-inositol

Direction not assertedBalancedRhea 20161

an N(5)-acyl-L-ornithine ester + H2O = an N(5)-acyl-L-ornithine + an alcohol + H(+)

Direction not assertedBalance undeterminableRhea 20165

pyridoxine + UDP-alpha-D-glucose = 5'-O-beta-D-glucosylpyridoxine + UDP + H(+)

Direction not assertedBalancedRhea 20177

alpha-D-mannose derivative + UDP-alpha-D-glucose = 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + UMP + H(+)

Direction not assertedBalance undeterminableRhea 20181

a CMP-N-acyl-beta-neuraminate + H2O = an N-acylneuraminate + CMP + H(+)

Direction not assertedBalance undeterminableRhea 20185

5,6-dihydrouracil + NAD(+) = uracil + NADH + H(+)

Direction not assertedBalancedRhea 20189

(R)-mevalonate + NADP(+) = (R)-mevaldate + NADPH + H(+)

Direction not assertedBalancedRhea 20193

[heparosan-N-sulfate](n) = [heparan-N-sulfate](n)

Direction not assertedBalance undeterminableRhea 20197

L-phenylalanine + ATP + H2O = D-phenylalanine + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 20201

methylazoxymethanol + UDP-alpha-D-glucose = cycasin + UDP + H(+)

Direction not assertedBalancedRhea 20205

xylitol + ATP = xylitol 5-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 20209

N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] = N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]

Direction not assertedBalance undeterminableRhea 20213

trimethylamine N-oxide + H(+) = dimethylamine + formaldehyde

Direction not assertedBalancedRhea 20217

(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate

Left to rightBalancedRhea 20221

(E)-caffeate + S-adenosyl-L-methionine = (E)-ferulate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 20225

2,3-dihydroxybenzoate + ATP + H(+) = 2,3-dihydroxybenzoyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 20229

a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + NADPH + H(+)

Right to leftBalance undeterminableRhea 20233

(1S,4S)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)

Direction not assertedBalancedRhea 20237

nicotinate + S-adenosyl-L-methionine = N-methylnicotinate + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 20241

streptomycin + ATP = 3''-O-adenylylstreptomycin + diphosphate

Direction not assertedBalancedRhea 20245

L-alanine = D-alanine

Direction not assertedBalancedRhea 20249

(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O

Direction not assertedBalancedRhea 20253

3-methyloxindole + NADP(+) = 3-methyleneoxindole + NADPH + H(+)

Direction not assertedBalancedRhea 20257

3,5,7-trioxododecanoyl-CoA = olivetol + CO2 + CoA

Direction not assertedBalancedRhea 20261

L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2

Direction not assertedBalancedRhea 20265

4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate

Direction not assertedBalancedRhea 20269

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

Direction not assertedBalancedRhea 20273

an N-hydroxyarylamine + acetyl-CoA = an N-acetoxyarylamine + CoA

Direction not assertedBalance undeterminableRhea 20277

(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate = (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 20281

beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine

Direction not assertedBalancedRhea 20285

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