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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,301–2,350 of 18,558 reactions from Rhea

GTP + H2O = GDP + phosphate + H(+)
Left to rightBalancedRhea 19669
1,2,3-trihydroxybenzene + O2 = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)
Direction not assertedBalancedRhea 19673
9'-cis-neoxanthin + O2 = (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin
Direction not assertedBalancedRhea 19677
biotin + ATP + CoA = biotinyl-CoA + AMP + diphosphate
Direction not assertedBalancedRhea 19681
(E)-feruloyl-CoA + tyramine = N-[(E)-feruloyl]tyramine + CoA + H(+)
Direction not assertedBalancedRhea 19685
L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate
Direction not assertedBalancedRhea 19689
5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD(+) + H2O = 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + NADH + 2 H(+)

Direction not assertedBalancedRhea 19693

11-cis-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

Direction not assertedBalancedRhea 19697

a flavonol 3-O-glycoside + UDP-alpha-D-xylose = a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 19701

hexadecanal + NAD(+) + CoA = hexadecanoyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 19705

a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

Left to rightBalance undeterminableRhea 19709

(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 19713

L-phenylalanine + H(+) = 2-phenylethylamine + CO2

Direction not assertedBalancedRhea 19717

octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 19721

UDP-alpha-D-galacturonate + H(+) = UDP-beta-L-arabinopyranose + CO2

Direction not assertedBalancedRhea 19725

acetoacetate + H(+) = acetone + CO2

Direction not assertedBalancedRhea 19729

3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) = bacteriochlorophyllide a + NADH + H(+)

Direction not assertedBalancedRhea 19733

4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate

Direction not assertedBalancedRhea 19737

formyl-CoA + H2O = formate + CoA + H(+)

Direction not assertedBalancedRhea 19741

3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

Right to leftBalancedRhea 19745

[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-alpha-D-glucosyl](n+1) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 19749

diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)

Direction not assertedBalance undeterminableRhea 19753

(3R)-3-hydroxy-L-aspartate = oxaloacetate + NH4(+)

Direction not assertedBalancedRhea 19757

FMN-N(5)-oxide + NADH + H(+) = FMN + NAD(+) + H2O

Direction not assertedBalancedRhea 19761

glycerol = 3-hydroxypropanal + H2O

Direction not assertedBalancedRhea 19765

phaseollidin hydrate = phaseollidin + H2O

Direction not assertedBalancedRhea 19769

sn-glycerol 3-phosphate + NADP(+) = D-glyceraldehyde 3-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 19773

L-pipecolate + A = L-1-piperideine-6-carboxylate + AH2 + H(+)

Direction not assertedBalancedRhea 19777

3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate

Direction not assertedBalancedRhea 19781

dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O

Direction not assertedBalancedRhea 19785

4-(dimethylamino)azobenzene + NADP(+) + H2O = 4-(dimethylamino)phenylazoxybenzene + NADPH + H(+)

Direction not assertedBalancedRhea 19789

(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + glycine

Left to rightBalance undeterminableRhea 19793

1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate

Left to rightBalancedRhea 19797

(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate

Left to rightBalancedRhea 19801

a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate

Direction not assertedBalance undeterminableRhea 19805

(S)-ureidoglycolate + H2O + 2 H(+) = glyoxylate + 2 NH4(+) + CO2

Direction not assertedBalancedRhea 19809

a 2-oxocarboxylate + L-asparagine = 2-oxosuccinamate + an L-alpha-amino acid

Direction not assertedBalance undeterminableRhea 19813

(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+)

Right to leftBalancedRhea 19817

(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADH + H(+)

Direction not assertedBalancedRhea 19821

(2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate

Direction not assertedBalancedRhea 19825

a primary alcohol + O2 = an aldehyde + H2O2

Direction not assertedBalance undeterminableRhea 19829

(6R)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)

Direction not assertedBalancedRhea 19833

D-sorbitol 6-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)

Direction not assertedBalancedRhea 19837

N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 19841

nocardicin E + S-adenosyl-L-methionine = isonocardicin A + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalancedRhea 19845

NADP(+) + H2O = ADP-D-ribose 2'-phosphate + nicotinamide + H(+)

Left to rightBalancedRhea 19849

a 16alpha-hydroxysteroid + NADP(+) = a 16-oxosteroid + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 19857

a 16alpha-hydroxysteroid + NAD(+) = a 16-oxosteroid + NADH + H(+)

Direction not assertedBalance undeterminableRhea 19861

uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2

Left to rightBalancedRhea 19865

an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

Left to rightBalance undeterminableRhea 19869

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