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2,301–2,350 of 12,877 reactions from Human-GEM
9-eicosenoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-11cis-docosenoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Fatty acid biosynthesis (unsaturated)Human-GEM MAR02353
3-oxo-11cis-docosenoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-11-cis-docosenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Fatty acid biosynthesis (unsaturated)Human-GEM MAR02354
3(S)-hydroxy-11-cis-docosenoyl-CoA[c] = H2O[c] + trans,cis-2,11-docosadienoyl-CoA[c]
Left to rightBalancedEC 4.2.1.134Fatty acid biosynthesis (unsaturated)Human-GEM MAR02355
H+[c] + NADPH[c] + trans,cis-2,11-docosadienoyl-CoA[c] = (11Z)-docosenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93
dGDP[m] + H2O[m] + oxidized thioredoxin[m] = GDP[m] + thioredoxin[m]
Left to rightBalancedEC 1.17.4.1MiscellaneousHuman-GEM MAR02357
H+[c] + NADPH[c] + O2[c] + oleoyl-CoA[c] = (6Z,9Z)-octadecadienoyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.19.-Fatty acid desaturation (even-chain)Human-GEM MAR02359
thioredoxin[c] = thioredoxin[m]
Left to rightBalancedTransportEC 3.4.19.9Transport reactionsHuman-GEM MAR02360
(6Z,9Z)-octadecadienoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-eicosadienoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Fatty acid biosynthesis (unsaturated)Human-GEM MAR02361
3-oxo-eicosadienoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-3-oxo-eicosadienoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Fatty acid biosynthesis (unsaturated)Human-GEM MAR02362
3(S)-hydroxy-3-oxo-eicosadienoyl-CoA[c] = H2O[c] + trans,cis-2,8,11-eicosatrienoyl-CoA[c]
Left to rightBalancedEC 4.2.1.134Fatty acid biosynthesis (unsaturated)Human-GEM MAR02363
H+[c] + NADPH[c] + trans,cis-2,8,11-eicosatrienoyl-CoA[c] = (8Z,11Z)-eicosadienoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Fatty acid biosynthesis (unsaturated)Human-GEM MAR02364
(8Z,11Z)-eicosadienoyl-CoA[c] + H+[c] + NADPH[c] + O2[c] = (5Z,8Z,11Z)-eicosatrienoyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.19.-Fatty acid desaturation (even-chain)Human-GEM MAR02365
H+[c] + linoleoyl-CoA[c] + NADPH[c] + O2[c] = gamma-linolenoyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.19.3Omega-6 fatty acid metabolismHuman-GEM MAR02368
gamma-linolenoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-dihomo-gamma-linolenoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Omega-6 fatty acid metabolismHuman-GEM MAR02371
3-oxo-dihomo-gamma-linolenoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-dihomo-gamma-linolenoyl-CoA[c] + NADP+[c]
Left to rightBalancedOmega-6 fatty acid metabolismHuman-GEM MAR02374
gamma-linolenoyl-CoA[r] + 4 H+[r] + 2 malonyl-CoA[r] + 2 NADPH[r] + 2 O2[r] = 4 CO2[r] + 2 CoA[r] + dihomo-gamma-linolenoyl-CoA[r] + 2 H2O[r] + 2 NADP+[r]
Left to rightBalancedEC 2.3.1.86MiscellaneousHuman-GEM MAR02375
3(S)-hydroxy-dihomo-gamma-linolenoyl-CoA[c] = H2O[c] + trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[c]
Left to rightBalancedOmega-6 fatty acid metabolismHuman-GEM MAR02376
oleoyl-CoA[c] = oleoyl-CoA[m]
ReversibleBalancedTransportEC 2.3.1.86Transport reactionsHuman-GEM MAR02377
H+[c] + NADPH[c] + trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[c] = dihomo-gamma-linolenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Omega-6 fatty acid metabolismHuman-GEM MAR02378
palmitoleoyl-CoA[c] = palmitoleoyl-CoA[m]
ReversibleBalancedTransportEC 2.3.1.86Transport reactionsHuman-GEM MAR02379
dihomo-gamma-linolenoyl-CoA[c] + H+[c] + NADPH[c] + O2[c] = arachidonyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.19.-Omega-6 fatty acid metabolismHuman-GEM MAR02380
3-oxooleoyl-CoA[m] + CoA[m] = acetyl-CoA[m] + palmitoleoyl-CoA[m]
Left to rightBalancedEC 2.3.1.86Fatty acid oxidationHuman-GEM MAR02381
GSH[c] = GSH[e]
Left to rightBalancedTransportEC 1.8.1.9Transport reactionsHuman-GEM MAR02382
arachidonyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-docosa-7,10,13,16-all-cis-tetraenoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Omega-6 fatty acid metabolismHuman-GEM MAR02383
ATP[c] + H2O[c] + Gm4-Pool[c] = ADP[c] + H+[c] + Pi[c] + Gm4-Pool[e]
Left to rightBalance undeterminableTransportEC 1.3.1.27Transport reactionsHuman-GEM MAR02385
ATP[c] + decanoic acid[c] + H2O[c] = ADP[c] + decanoic acid[e] + H+[c] + Pi[c]
Left to rightBalancedTransportEC 1.3.1.27Transport reactionsHuman-GEM MAR02386
3-oxo-docosa-7,10,13,16-all-cis-tetraenoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-docosa-7,10,13,16-all-cis-tetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Omega-6 fatty acid metabolismHuman-GEM MAR02387
chloride[e] + Na+[e] + taurine[e] = chloride[c] + Na+[c] + taurine[c]
Left to rightBalancedTransportEC 2.3.1.86Transport reactionsHuman-GEM MAR02388
3(S)-hydroxy-docosa-7,10,13,16-all-cis-tetraenoyl-CoA[c] = (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA[c] + H2O[c]
Left to rightBalancedEC 4.2.1.134Omega-6 fatty acid metabolismHuman-GEM MAR02389
(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA[c] + H+[c] + NADPH[c] = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedOmega-6 fatty acid metabolismHuman-GEM MAR02391
(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA[c] + H+[c] + NADPH[c] + O2[c] = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedOmega-6 fatty acid metabolismHuman-GEM MAR02393
(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-tetracosa-9,12,15,18-all-cis-tetraenoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Omega-6 fatty acid metabolismHuman-GEM MAR02395
10-HETE[e] + glutathionyl-leukotriene C4[c] + HCO3-[c] = 10-HETE[c] + glutathionyl-leukotriene C4[e] + HCO3-[e]
ReversibleBalance undeterminableTransportTransport reactionsHuman-GEM MAR02396
3-oxo-tetracosa-9,12,15,18-all-cis-tetraenoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-tetracosa-12,15,18,21-all-cis-tetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Omega-6 fatty acid metabolismHuman-GEM MAR02397
10-HETE[e] + HCO3-[c] + S-glutathionyl-2-4-dinitrobenzene[c] = 10-HETE[c] + HCO3-[e] + S-glutathionyl-2-4-dinitrobenzene[e]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR02398
3(S)-hydroxy-tetracosa-12,15,18,21-all-cis-tetraenoyl-CoA[c] = 2-trans-9,12,15,18-all-cis-tetracosapentaenoyl-CoA[c] + H2O[c]
Left to rightBalancedEC 4.2.1.134Omega-6 fatty acid metabolismHuman-GEM MAR02399
10-HETE[e] + HCO3-[c] + S-glutathionyl-ethacrynic acid[c] = 10-HETE[c] + HCO3-[e] + S-glutathionyl-ethacrynic acid[e]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR02400
2-trans-9,12,15,18-all-cis-tetracosapentaenoyl-CoA[c] + H+[c] + NADPH[c] = (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Omega-6 fatty acid metabolismHuman-GEM MAR02401
10-HETE[e] + GSH[c] + HCO3-[c] = 10-HETE[c] + GSH[e] + HCO3-[e]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR02402
(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA[c] + H+[c] + NADPH[c] + O2[c] = (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedOmega-6 fatty acid metabolismHuman-GEM MAR02403
10-HETE[e] = 10-HETE[c]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR02404
AKG[c] + citrate[m] = AKG[m] + citrate[c]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR02405
citrate[m] + oxalate[c] = citrate[c] + oxalate[m]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR02406
(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA[c] = (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA[x]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR02407
(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA[x] + FAD[x] = FADH2[x] + trans-2-all-cis-6,9,12,15,18-tetracosahexaenoyl-CoA[x]
Left to rightBalancedEC 1.3.3.6Omega-6 fatty acid metabolismHuman-GEM MAR02408
H2O[x] + trans-2-all-cis-6,9,12,15,18-tetracosahexaenoyl-CoA[x] = 3(S)-hydroxy-tetracosa-6,9,12,15,18-all-cis-pentaenoyl-CoA[x]
Left to rightBalancedEC 4.2.1.17Omega-6 fatty acid metabolismHuman-GEM MAR02409
3(S)-hydroxy-tetracosa-6,9,12,15,18-all-cis-pentaenoyl-CoA[x] + NAD+[x] = 3-oxo-all-cis-6,9,12,15,18-tetracosapentaenoyl-CoA[x] + H+[x] + NADH[x]
Left to rightBalancedEC 1.1.1.35, 1.1.1.211Omega-6 fatty acid metabolismHuman-GEM MAR02410
3-oxo-all-cis-6,9,12,15,18-tetracosapentaenoyl-CoA[x] + CoA[x] = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA[x] + acetyl-CoA[x]
Left to rightBalancedEC 2.3.1.16Omega-6 fatty acid metabolismHuman-GEM MAR02411
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA[c] = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA[x]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR02412
isocitrate[m] + succinate[c] = isocitrate[c] + succinate[m]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR02413