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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,251–2,300 of 18,558 reactions from Rhea

3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)
Direction not assertedBalance undeterminableRhea 19461
2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)
Direction not assertedBalancedRhea 19465
2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)
Direction not assertedBalancedRhea 19469
4-hydroxybenzoate + NADH + O2 + H(+) = 3,4-dihydroxybenzoate + NAD(+) + H2O
Direction not assertedBalancedRhea 19473
4-hydroxybenzoate + NADPH + O2 + H(+) = 3,4-dihydroxybenzoate + NADP(+) + H2O
Direction not assertedBalancedRhea 19477
succinyl-CoA + acetyl-CoA = 3-oxoadipyl-CoA + CoA
Direction not assertedBalancedRhea 19481

sphing-4-enine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1)-sphing-4-enine + UDP + H(+)

Direction not assertedBalancedRhea 19485

dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide = 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)

Direction not assertedBalancedRhea 19489

D-cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose

Direction not assertedBalancedRhea 19493

L-aspartate + H(+) = beta-alanine + CO2

Direction not assertedBalancedRhea 19497

4-guanidinobutanoate + H2O = urea + 4-aminobutanoate

Left to rightBalancedRhea 19501

indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + UDP + H(+)

Direction not assertedBalancedRhea 19505

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = L-erythro-biopterin + 2 NADPH + 2 H(+)

Direction not assertedBalancedRhea 19509

carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)

Right to leftBalancedRhea 19513

N,N-dimethylformamide + H2O = dimethylamine + formate

Direction not assertedBalancedRhea 19517

acetyl-CoA + phosphate = acetyl phosphate + CoA

Direction not assertedBalancedRhea 19521

(2E,6E)-farnesyl diphosphate = (1S,8aR)-delta-cadinene + diphosphate

Direction not assertedBalancedRhea 19525

isovitexin + UDP-alpha-D-glucose = isovitexin 2''-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 19529

N(2)-succinyl-L-arginine + 2 H2O + 2 H(+) = N(2)-succinyl-L-ornithine + 2 NH4(+) + CO2

Direction not assertedBalancedRhea 19533

D-mannitol 1-phosphate + H2O = D-mannitol + phosphate

Direction not assertedBalancedRhea 19537

L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 19541

sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)

Left to rightBalancedRhea 19545

o-orsellinate depside + H2O = 2 orsellinate + H(+)

Direction not assertedBalancedRhea 19549

L-tryptophan + H2O = indole + pyruvate + NH4(+)

Direction not assertedBalancedRhea 19553

pregna-4,9(11)-diene-3,20-dione + AH2 + O2 = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O

Direction not assertedBalancedRhea 19557

androst-4-ene-3,17-dione + NADPH + O2 + H(+) = testololactone + NADP(+) + H2O

Direction not assertedBalancedRhea 19561

(2E)-geranyl diphosphate + H2O = sabinene hydrate + diphosphate

Direction not assertedBalancedRhea 19565

5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 19569

[phosphate](n) + ATP = [phosphate](n+1) + ADP

Direction not assertedBalance undeterminableRhea 19573

luteolin + UDP-alpha-D-glucose = luteolin 7-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 19577

N(6)-dimethylallyladenine + S-adenosyl-L-methionine = discadenine + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalancedRhea 19581

lithocholate + NAD(+) = 3-oxo-5beta-cholan-24-oate + NADH + H(+)

Direction not assertedBalancedRhea 19585

L-arginine + H2O = L-citrulline + NH4(+)

Direction not assertedBalancedRhea 19597

orcinol + NADH + O2 + H(+) = 2,3,5-trihydroxytoluene + NAD(+) + H2O

Direction not assertedBalancedRhea 19601

a chlorophyll + H2O = a chlorophyllide + phytol + H(+)

Direction not assertedBalance undeterminableRhea 19605

adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)

Direction not assertedUnbalancedRhea 19609

dimethyl sulfide + S-adenosyl-L-methionine = trimethylsulfonium + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 19613

a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 19617

a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)

Direction not assertedBalance undeterminableRhea 19621

L-threonine = acetaldehyde + glycine

Left to rightBalancedRhea 19625

D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH

Left to rightBalancedRhea 19629

(3S,5S)-3,5-diaminohexanoate + NAD(+) + H2O = (5S)-5-amino-3-oxohexanoate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 19633

D-nopaline + NADP(+) + H2O = L-arginine + 2-oxoglutarate + NADPH + H(+)

Direction not assertedBalancedRhea 19637

(E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 19641

a D-threo-aldose + NAD(+) = a D-threo-aldono-1,5-lactone + NADH + H(+)

Direction not assertedBalance undeterminableRhea 19645

tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate

Direction not assertedBalancedRhea 19649

CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NAD(+) + H2O = CDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H(+)

Direction not assertedBalancedRhea 19653

CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADP(+) + H2O = CDP-4-dehydro-6-deoxy-alpha-D-glucose + NADPH + H(+)

Direction not assertedBalancedRhea 19657

D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)

Direction not assertedBalancedRhea 19661

6-carboxyhexanoyl-CoA + NAD(+) = 6-carboxyhex-2-enoyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 19665

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