Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,201–2,250 of 18,558 reactions from Rhea

a secondary alcohol + NADP(+) = a ketone + NADPH + H(+)
Right to leftBalance undeterminableRhea 19257
heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H(+)
Left to rightBalancedTransportRhea 19261
carnitine + NAD(+) = 3-dehydrocarnitine + NADH + H(+)
Direction not assertedBalancedRhea 19265
2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate
Direction not assertedBalancedRhea 19269
N-acetyl-D-mannosamine + phosphoenolpyruvate + H2O = N-acetylneuraminate + phosphate
Direction not assertedBalancedRhea 19273
tRNA(Pyl) + L-pyrrolysine + ATP = L-pyrrolysyl-tRNA(Pyl) + AMP + diphosphate
Direction not assertedBalancedRhea 19277
(7S)-marmesin + reduced [NADPH--hemoprotein reductase] + O2 = psoralen + acetone + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 19281

a di-trans,poly-cis-dolichol + a 1,2-diacyl-sn-glycero-3-phosphocholine = an acyl-di-trans,poly-cis-dolichol + a 1-acyl-sn-glycero-3-phosphocholine

Direction not assertedBalance undeterminableRhea 19285

sucrose 6(F)-phosphate + H2O = sucrose + phosphate

Direction not assertedBalancedRhea 19289

a monoacylglycerol + ATP = a monoacyl-sn-glycero-3-phosphate + ADP + H(+)

Left to rightBalance undeterminableRhea 19293

beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)

Left to rightBalancedRhea 19297

histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 19301

3-hydroxybenzoyl-CoA + 3 malonyl-CoA + 2 H(+) = 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA

Direction not assertedBalancedRhea 19305

2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate

Direction not assertedBalancedRhea 19309

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)

Left to rightBalance undeterminableRhea 19313

5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + hydrogencarbonate + ATP = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + phosphate + 2 H(+)

Direction not assertedBalancedRhea 19317

N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde

Direction not assertedBalancedRhea 19321

quinolin-4-ol + NADH + O2 + H(+) = quinoline-3,4-diol + NAD(+) + H2O

Direction not assertedBalancedRhea 19325

nuatigenin + UDP-alpha-D-glucose = nuatigenin 3-beta-D-glucopyranoside + UDP + H(+)

Direction not assertedBalancedRhea 19329

oxalyl-CoA + H(+) = formyl-CoA + CO2

Direction not assertedBalancedRhea 19333

2 hydroxylamine + 2 NAD(+) = hyponitrous acid + 2 NADH + 2 H(+)

Direction not assertedBalancedRhea 19337

octane + 2 reduced [rubredoxin] + O2 + 2 H(+) = 2 oxidized [rubredoxin] + octan-1-ol + H2O

Direction not assertedBalance undeterminableRhea 19341

(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate

Direction not assertedBalancedRhea 19345

(R)-4-dehydropantoate + NAD(+) + H2O = (R)-3,3-dimethylmalate + NADH + 2 H(+)

Direction not assertedBalancedRhea 19349

glycocholate + H2O = cholate + glycine

Direction not assertedBalancedRhea 19353

L-proline betaine + NADPH + O2 + H(+) = N-methyl-L-proline + formaldehyde + NADP(+) + H2O

Direction not assertedBalancedRhea 19357

isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate

Direction not assertedBalancedRhea 19361

D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 19365

L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 19369

L-saccharopine + NADP(+) + H2O = L-lysine + 2-oxoglutarate + NADPH + H(+)

Right to leftBalancedRhea 19373

reduced riboflavin + NADP(+) = riboflavin + NADPH + 2 H(+)

Right to leftBalancedRhea 19377

(S)-oxalosuccinate + H(+) = 2-oxoglutarate + CO2

Direction not assertedBalancedRhea 19381

vomilenine + UDP-alpha-D-glucose = raucaffricine + UDP + H(+)

Direction not assertedBalancedRhea 19385

(E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + ADP + phosphate

Direction not assertedBalancedRhea 19389

L-lysine + pyruvate = (S)-2-amino-6-oxohexanoate + L-alanine

Direction not assertedBalancedRhea 19393

(R)-4'-phosphopantothenate + L-cysteine + CTP = N-[(R)-4-phosphopantothenoyl]-L-cysteine + CMP + diphosphate + H(+)

Left to rightBalancedRhea 19397

methanol + NAD(+) = formaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 19401

citrate + acetyl-CoA = (3S)-citryl-CoA + acetate

Direction not assertedBalancedRhea 19405

cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H(+)

Left to rightBalancedRhea 19409

tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)

Left to rightBalancedRhea 19413

a di-trans,poly-cis-dolichyl diphosphate + [phosphate](n) = [phosphate](n+1) + a di-trans,poly-cis-dolichyl phosphate

Direction not assertedBalance undeterminableRhea 19417

(R)-2-hydroxypropyl-coenzyme M = (R)-1,2-epoxypropane + coenzyme M

Direction not assertedBalancedRhea 19421

imidazole-4-acetate + NADH + O2 + H(+) = 5-hydroxyimidazole-4-acetate + NAD(+) + H2O

Direction not assertedBalancedRhea 19425

[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+)

Left to rightBalance undeterminableRhea 19429

D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)

Left to rightBalancedRhea 19433

nicotinate + UDP-alpha-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP

Direction not assertedBalancedRhea 19437

benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H(+)

Direction not assertedBalancedRhea 19441

2,3-dihydroxyindole + O2 = anthranilate + CO2 + H(+)

Direction not assertedBalancedRhea 19445

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate

Direction not assertedBalancedRhea 19453

2-nitrophenol + 2 NADPH + O2 + 2 H(+) = catechol + nitrite + 2 NADP(+) + H2O

Direction not assertedBalancedRhea 19457

Page 45 of 372