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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
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PathwaysReactions grouped under one name
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AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reach

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Organisms
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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,151–2,200 of 18,558 reactions from Rhea

pyruvate + acetyl-CoA + H2O = (3R)-citramalate + CoA + H(+)
Direction not assertedBalancedRhea 19045
(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)
Direction not assertedBalancedRhea 19049
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H(+)
Direction not assertedBalancedRhea 19053
a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O
Left to rightBalance undeterminableRhea 19057
nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)
Direction not assertedBalancedRhea 19061
(R)-S-lactoylglutathione = methylglyoxal + glutathione
Right to leftBalancedRhea 19069
L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 19073

N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] + H2O = 3-deoxyglucosone + L-lysyl-[protein] + phosphate

Direction not assertedBalance undeterminableRhea 19077

1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)

Direction not assertedBalance undeterminableRhea 19081

dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate

Direction not assertedBalancedRhea 19085

uroporphyrinogen III + S-adenosyl-L-methionine = precorrin-1 + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 19089

siroheme + 2 H(+) = 12,18-didecarboxysiroheme + 2 CO2

Direction not assertedBalancedRhea 19093

2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + NADH + H(+)

Direction not assertedBalancedRhea 19101

4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+)

Left to rightBalancedRhea 19105

1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)

Direction not assertedBalancedRhea 19109

(8Z,11Z,14Z)-heptadecatrienal + A + H2O = (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)

Direction not assertedBalancedRhea 19113

dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O

Left to rightBalancedRhea 19117

an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 19121

glyoxylate + L-serine = 3-hydroxypyruvate + glycine

Direction not assertedBalancedRhea 19125

thymidine + ATP = dTMP + ADP + H(+)

Left to rightBalancedRhea 19129

3,3',5-triiodo-L-thyronine + 2-oxoglutarate = 3,5,3'-triiodothyropyruvate + L-glutamate

Direction not assertedBalancedRhea 19133

17beta-estradiol + AH2 + O2 = 6beta-hydroxyestradiol-17beta + A + H2O

Direction not assertedBalancedRhea 19137

all-trans-retinol = 11-cis-retinol

ReversibleBalancedRhea 19141

D-glucose 6-sulfate + H2O = sulfate + D-glucose + H(+)

Direction not assertedBalancedRhea 19145

L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+)

Left to rightBalance undeterminableRhea 19149

UDP-alpha-D-apiose + apigenin 7-O-beta-D-glucoside = 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + UDP + H(+)

Direction not assertedBalancedRhea 19153

D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O

Direction not assertedBalancedRhea 19157

a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + UDP + H(+)

Direction not assertedBalance undeterminableRhea 19165

L-serine = pyruvate + NH4(+)

Direction not assertedBalancedRhea 19169

naphthalene + NADH + O2 + H(+) = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)

Direction not assertedBalancedRhea 19173

L-lysine = (3S)-3,6-diaminohexanoate

Direction not assertedBalancedRhea 19177

a very-long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 19181

propanoyl-CoA + glyoxylate + H2O = 2-hydroxyglutarate + CoA + H(+)

Direction not assertedBalancedRhea 19185

N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2

Left to rightBalance undeterminableRhea 19189

all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

Direction not assertedBalancedRhea 19193

adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)

Direction not assertedBalancedRhea 19197

2'-deoxyguanosine + ATP = dGMP + ADP + H(+)

Direction not assertedBalancedRhea 19201

dCTP + 2 H2O = dUMP + NH4(+) + diphosphate

Direction not assertedBalancedRhea 19205

codeine + NADP(+) = codeinone + NADPH + H(+)

Direction not assertedBalancedRhea 19209

an S-substituted L-cysteine + acetyl-CoA = an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)

Left to rightBalance undeterminableRhea 19213

1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)

Direction not assertedBalancedRhea 19217

2 formaldehyde + H2O = methanol + formate + H(+)

Direction not assertedBalancedRhea 19221

glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = glycin-2-yl radical-[formate C-acetyltransferase] + semiquinone [flavodoxin] + 5'-deoxyadenosine + L-methionine + H(+)

Direction not assertedBalance undeterminableRhea 19225

an aromatic aldehyde + AMP + diphosphate + NADP(+) = an aromatic carboxylate + ATP + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 19229

S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)

Left to rightBalance undeterminableRhea 19233

4-methylmuconolactone = 3-methylmuconolactone

Direction not assertedBalancedRhea 19237

ent-kaur-16-en-19-oate + reduced [NADPH--hemoprotein reductase] + O2 = ent-7alpha-hydroxykaur-16-en-19-oate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 19241

N-phenylhydroxylamine = 2-aminophenol

Direction not assertedBalancedRhea 19245

L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine

Direction not assertedBalancedRhea 19249

a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)

Left to rightBalance undeterminableRhea 19253

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