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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

21,301–21,350 of 31,435, by identifier

(E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+)
Direction not assertedBalancedRhea 45724
(E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+)
Direction not assertedBalancedRhea 45728
D-ribulose 5-phosphate + L-tyrosine = (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O + H(+)
Direction not assertedBalancedRhea 45732
(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA
Left to rightBalancedRhea 45736
L-ectoine + 2-oxoglutarate + O2 = 5-hydroxyectoine + succinate + CO2
Direction not assertedBalancedRhea 45740
(6S)-5,6,7,8-tetrahydropteroate + NAD(+) = 7,8-dihydropteroate + NADH + H(+)
Direction not assertedBalancedRhea 45744
(3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA

Left to rightBalancedRhea 45748

(3E)-decenoyl-CoA = (2E)-decenoyl-CoA

Left to rightBalancedRhea 45752

N,N-dimethylglycine + (6S)-5,6,7,8-tetrahydrofolate + O2 = sarcosine + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2

Direction not assertedBalancedRhea 45756

dTDP-beta-L-daunosamine + epsilon-rhodomycinone = rhodomycin D + dTDP + H(+)

Direction not assertedBalancedRhea 45760

L-aspartate 4-semialdehyde + NAD(+) + H2O = L-aspartate + NADH + 2 H(+)

Direction not assertedBalancedRhea 45764

gamma-L-glutamyl-L-alaninol + H2O = L-alaninol + L-glutamate

Direction not assertedBalancedRhea 45768

[(1->4)-beta-D-mannosyl](n) + phosphate = [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate

Direction not assertedBalance undeterminableRhea 45772

(indol-3-yl)acetonitrile + 2 H2O = (indol-3-yl)acetate + NH4(+)

Direction not assertedBalancedRhea 45776

di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA

Direction not assertedBalancedRhea 45780

phenylpropanonitrile + 2 H2O = 3-phenylpropanoate + NH4(+)

Direction not assertedBalancedRhea 45784

1,2-dihexadecanoyl-sn-glycerol + (9Z)-hexadecenoyl-CoA = 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA

Direction not assertedBalancedRhea 45788

[ribosomal protein S23]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein S23]-trans-3-hydroxy-L-proline + succinate + CO2

Direction not assertedBalance undeterminableRhea 45792

(3R)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 45796

15-demethylaclacinomycin T + AH2 + O2 = 10-decarboxymethylaclacinomycin T + A + CO2 + H2O

Direction not assertedBalancedRhea 45800

hydroxylamine + L-glutamate + ATP = L-glutamine hydroxamate + ADP + phosphate

Direction not assertedBalancedRhea 45804

galactarate = (2S,3R)-dihydroxy-5-oxohexanedioate + H2O

Direction not assertedBalancedRhea 45808

a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O

ReversibleBalance undeterminableRhea 45812

(S)-lactate + A = pyruvate + AH2

Direction not assertedBalancedRhea 45816

mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate

Direction not assertedBalancedRhea 45820

L-serine + H(+) = ethanolamine + CO2

Direction not assertedBalancedRhea 45824

(3R)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 45828

(3R)-3-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)

Left to rightBalancedRhea 45832

1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate

Left to rightBalancedRhea 45836

(3R)-3-hydroxydecanoyl-CoA + NADP(+) = 3-oxodecanoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 45840

(3R)-hydroxyoctanoyl-CoA + NADP(+) = 3-oxooctanoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 45844

(3R)-3-hydroxydodecanoyl-CoA + NADP(+) = 3-oxododecanoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 45848

Co(II)-factor III + S-adenosyl-L-methionine + H(+) = Co(II)-factor IV + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 45852

3-hydroxytetradecanoyl-CoA + 2 malonyl-CoA + 2 H(+) = 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA

Direction not assertedBalancedRhea 45856

12-hydroxyoctadecanoyl-CoA + 2 malonyl-CoA + 2 H(+) = 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA

Direction not assertedBalancedRhea 45860

16-hydroxyhexadecanoyl-CoA + 2 malonyl-CoA + 2 H(+) = 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA

Direction not assertedBalancedRhea 45864

9-decenoyl-CoA + 2 malonyl-CoA + 2 H(+) = 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA

Direction not assertedBalancedRhea 45868

15-hydroxypentadecanoyl-CoA + 2 malonyl-CoA + 2 H(+) = 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA

Direction not assertedBalancedRhea 45872

2-methylhexadecanoyl-CoA + 2 malonyl-CoA + 2 H(+) = 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA

Direction not assertedBalancedRhea 45876

3-methylundecanoyl-CoA + 2 malonyl-CoA + 2 H(+) = 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA

Direction not assertedBalancedRhea 45880

12-methyloctadecanoyl-CoA + 2 malonyl-CoA + 2 H(+) = 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA

Direction not assertedBalancedRhea 45884

12-methyltridecanoyl-CoA + 2 malonyl-CoA + 2 H(+) = 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA

Direction not assertedBalancedRhea 45888

CDP-ethanolamine + an N-acylsphing-4-enine = an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)

Direction not assertedBalance undeterminableRhea 45892

CDP-ethanolamine + an N-acyl-sphingoid base = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H(+)

Direction not assertedBalance undeterminableRhea 45896

a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA

Left to rightBalance undeterminableRhea 45900

dTDP-beta-L-vancosamine + devancoaminyl-vancomycin = epivancomycin + dTDP + H(+)

Direction not assertedBalancedRhea 45904

chloroorienticin B + dTDP-beta-L-vancosamine = chloroeremomycin + dTDP + H(+)

Direction not assertedBalancedRhea 45908

a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)

Left to rightBalance undeterminableRhea 45912

12-hydroxyoctadecanoyl-CoA + 3 malonyl-CoA + 3 H(+) = 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA

Direction not assertedBalancedRhea 45916

16-hydroxyhexadecanoyl-CoA + 3 malonyl-CoA + 3 H(+) = 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA

Direction not assertedBalancedRhea 45920

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