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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

2,051–2,100 of 18,558 reactions from Rhea

4-methoxybenzoate + AH2 + O2 = 4-hydroxybenzoate + formaldehyde + A + H2O
Direction not assertedBalancedRhea 18613
oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2
Direction not assertedBalancedRhea 18617
a (2S)-flavan-4-one + 2-oxoglutarate + O2 = a (2R,3R)-dihydroflavonol + succinate + CO2
Direction not assertedBalance undeterminableRhea 18621
D-galactose + NADP(+) = D-galactono-1,5-lactone + NADPH + H(+)
Direction not assertedBalancedRhea 18625
NAD(+) + ATP = ADP + NADP(+) + H(+)
Direction not assertedBalancedRhea 18629
hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)
Direction not assertedBalancedRhea 18633
H2 + NADP(+) = NADPH + H(+)

Direction not assertedBalancedRhea 18637

H2 + a menaquinone = a menaquinol

Direction not assertedBalance undeterminableRhea 18641

2 putrescine = sym-homospermidine + NH4(+)

Direction not assertedBalancedRhea 18645

D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O

Direction not assertedBalancedRhea 18649

barbiturate + H2O = 3-oxo-3-ureidopropanoate

Direction not assertedBalancedRhea 18653

(R)-glycerate + NADP(+) = 3-hydroxypyruvate + NADPH + H(+)

Direction not assertedBalancedRhea 18657

N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) + H2O = L-ornithine + pyruvate + NADPH + H(+)

Direction not assertedBalancedRhea 18661

[phosphate](n) + (2R)-3-phospho-glyceroyl phosphate = [phosphate](n+1) + (2R)-3-phosphoglycerate

Direction not assertedBalance undeterminableRhea 18665

adenosine + H2O = D-ribose + adenine

Direction not assertedBalancedRhea 18669

L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)

Left to rightBalance undeterminableRhea 18673

phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + phosphate

Direction not assertedBalancedRhea 18681

pentachlorophenol + NADPH + O2 + H(+) = 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + NADP(+) + H2O

Direction not assertedBalancedRhea 18685

a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 18689

a penicillin + H2O = 6-aminopenicillanate + a carboxylate

Direction not assertedBalance undeterminableRhea 18693

3-(4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO2

Direction not assertedBalancedRhea 18697

2 oxidized [azurin] + arsenite + H2O = 2 reduced [azurin] + arsenate + 3 H(+)

Direction not assertedBalance undeterminableRhea 18701

a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)

Direction not assertedBalance undeterminableRhea 18705

taurine + A + H2O = sulfoacetaldehyde + AH2 + NH4(+)

Direction not assertedBalancedRhea 18709

3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 18717

ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = ent-13-epi-manoyl oxide + diphosphate

Direction not assertedBalancedRhea 18721

3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = vanillin + acetyl-CoA

Direction not assertedBalancedRhea 18725

hydrogenselenide + ATP + H2O = selenophosphate + AMP + phosphate + 2 H(+)

Left to rightBalancedRhea 18737

10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA

Direction not assertedBalancedRhea 18741

2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)

Direction not assertedBalancedRhea 18745

[protein]-dithiol + NAD(+) = [protein]-disulfide + NADH + H(+)

Direction not assertedBalance undeterminableRhea 18749

[protein]-dithiol + NADP(+) = [protein]-disulfide + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 18753

7-deoxycylindrospermopsin + 2-oxoglutarate + O2 = cylindrospermopsin + succinate + CO2

Direction not assertedBalancedRhea 18757

a 1,2-diacyl-sn-glycerol + H2O = a monoacylglycerol + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 18761

an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol

ReversibleBalance undeterminableRhea 18765

5-methylsulfanyl-2,3-dioxopentyl phosphate = 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate

Direction not assertedBalancedRhea 18769

methyl-Co(III)-[methylamine-specific corrinoid protein] + coenzyme M = Co(I)-[methylamine-specific corrinoid protein] + methyl-coenzyme M + H(+)

Direction not assertedBalance undeterminableRhea 18773

an alkylmercury + H(+) = an alkane + Hg(2+)

Direction not assertedBalance undeterminableRhea 18777

malonyl-CoA + H(+) = acetyl-CoA + CO2

Left to rightBalancedRhea 18781

gibberellin A12 aldehyde + A + H2O = gibberellin A12 + AH2 + H(+)

Direction not assertedBalancedRhea 18785

D-glucosamine 6-phosphate = D-galactosamine 6-phosphate

Direction not assertedBalancedRhea 18789

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate

Direction not assertedBalancedRhea 18793

a 3'-hydroxy,5'-unsubstituted flavanone + reduced [NADPH--hemoprotein reductase] + O2 = a 3',5'-dihydroxyflavanone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 18797

(cis-prenyl)(n)-diphosphate + isopentenyl diphosphate = (cis-prenyl)(n+1)-diphosphate + diphosphate

Direction not assertedBalance undeterminableRhea 18801

[DsbA protein]-disulfide + [protein]-dithiol = [DsbA protein]-dithiol + [protein]-disulfide

Direction not assertedBalance undeterminableRhea 18805

oxomalonate + L-alanine = aminomalonate + pyruvate

Direction not assertedBalancedRhea 18809

(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate

Direction not assertedBalancedRhea 18813

malonate + acetyl-CoA = acetate + malonyl-CoA

Direction not assertedBalancedRhea 18817

choline + acetyl-CoA = acetylcholine + CoA

Direction not assertedBalancedRhea 18821

[(1->6)-alpha-D-glucosyl](n) + sucrose = [(1->6)-alpha-D-glucosyl](n+1) + D-fructose

Direction not assertedBalance undeterminableRhea 18825

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