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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

20,651–20,700 of 31,435, by identifier

N2 + 2 Fe(III)-[cytochrome c] + H2O = nitrous oxide + 2 Fe(II)-[cytochrome c] + 2 H(+)
Direction not assertedBalance undeterminableRhea 43108
(R)-mandelate + NAD(+) = phenylglyoxylate + NADH + H(+)
Direction not assertedBalancedRhea 43112
N-octanoylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = N-octanoyl-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O
Left to rightBalance undeterminableRhea 43116
xanthine + 2-oxoglutarate + O2 = urate + succinate + CO2
Direction not assertedBalancedRhea 43120
guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)
Direction not assertedBalancedRhea 43124
guanosine(10) in tRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine + H(+)
Left to rightBalancedRhea 43128

N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine = N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43132

guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)

Direction not assertedUnbalancedRhea 43136

guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 43140

adenosine(22) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43144

adenosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43148

adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43152

guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43156

adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine = N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43160

guanosine(15) in tRNA + 7-cyano-7-carbaguanine = 7-cyano-7-carbaguanosine(15) in tRNA + guanine

Direction not assertedBalancedRhea 43164

adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+)

Direction not assertedBalancedRhea 43168

guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 43172

cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2870) in 25S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43176

cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2278) in 25S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43180

uridine(2843) in 25S rRNA + S-adenosyl-L-methionine = N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43184

uridine(2634) in 25S rRNA + S-adenosyl-L-methionine = N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43188

cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43192

adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43196

cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1920) in 23S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43200

cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1409) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43204

5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 43208

adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43212

a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + (24S)-hydroxycholesterol = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine

Left to rightBalance undeterminableRhea 43216

guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 43220

(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine

Left to rightBalancedRhea 43224

L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 43228

isatin + H2O = isatinate + H(+)

Direction not assertedBalancedRhea 43232

1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate

Left to rightBalancedRhea 43236

1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate

Left to rightBalancedRhea 43240

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate

Left to rightBalancedRhea 43244

1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate

Left to rightBalancedRhea 43248

1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate

Left to rightBalancedRhea 43252

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate

Left to rightBalancedRhea 43256

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate

Left to rightBalancedRhea 43260

eicosanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA

Left to rightBalancedRhea 43264

a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 + UDP + H(+)

Left to rightBalance undeterminableRhea 43268

a ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GD2 + UDP + H(+)

Left to rightBalance undeterminableRhea 43272

a ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GalNAc-GD1a + UDP + H(+)

Left to rightBalance undeterminableRhea 43276

1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate

Left to rightBalancedRhea 43280

1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate

Left to rightBalancedRhea 43284

1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate

Left to rightBalancedRhea 43288

1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate

Left to rightBalancedRhea 43292

1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate

Left to rightBalancedRhea 43296

a neolactoside IV(3)-alpha-NeuGc-nLc4Cer + UDP-N-acetyl-alpha-D-galactosamine = a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer + UDP + H(+)

Left to rightBalance undeterminableRhea 43300

a beta-D-Gal-(1<->1')-ceramide + 3'-phosphoadenylyl sulfate = 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 43304

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