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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Processes
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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

1,951–2,000 of 18,558 reactions from Rhea

N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + H2O = (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate
Direction not assertedBalance undeterminableRhea 18193
N-cyclohexylformamide = cyclohexyl isocyanide + H2O
Direction not assertedBalancedRhea 18197
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
Left to rightBalancedRhea 18201
(2E)-geranyl diphosphate = (2S,4R)-bornyl diphosphate
Direction not assertedBalancedRhea 18209
alpha-D-glucose 1-phosphate + CTP + H(+) = CDP-D-glucose + diphosphate
Direction not assertedBalancedRhea 18213
an alkane-alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate
Direction not assertedBalance undeterminableRhea 18217

a 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate

Direction not assertedBalance undeterminableRhea 18221

[N-(6-aminohexanoyl)](n) + H2O = [N-(6-aminohexanoyl)](n-1) + 6-aminohexanoate

Direction not assertedBalance undeterminableRhea 18225

glycolate + NAD(+) = glyoxylate + NADH + H(+)

Direction not assertedBalancedRhea 18229

2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H(+)

Direction not assertedBalancedRhea 18237

D-lysine = (2R,5S)-2,5-diaminohexanoate

Direction not assertedBalancedRhea 18241

3'-dephospho-CoA + ATP = ADP + CoA + H(+)

Left to rightBalancedRhea 18245

(S)-malate + NADP(+) = pyruvate + CO2 + NADPH

ReversibleBalancedRhea 18253

coproporphyrinogen III + O2 + 2 H(+) = protoporphyrinogen IX + 2 CO2 + 2 H2O

Left to rightBalancedRhea 18257

precorrin-5 + S-adenosyl-L-methionine + H2O = precorrin-6A + acetate + S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 18261

6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) = 6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 18265

ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + NADPH + H(+)

Direction not assertedBalancedRhea 18269

putrescine + O2 + H2O = 4-aminobutanal + H2O2 + NH4(+)

Left to rightBalancedRhea 18273

a thiol + S-adenosyl-L-methionine = a methyl thioether + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 18277

succinate + NAD(+) = fumarate + NADH + H(+)

Direction not assertedBalancedRhea 18281

an N-acyl-D-aspartate + H2O = D-aspartate + a carboxylate

Direction not assertedBalance undeterminableRhea 18285

(S,S)-tartrate = oxaloacetate + H2O

Direction not assertedBalancedRhea 18289

oxalate + ATP + CoA = oxalyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 18293

a phtalamide + H2O = phthalate + a primary amine

Direction not assertedBalance undeterminableRhea 18297

XMP + NH4(+) + ATP = GMP + AMP + diphosphate + 2 H(+)

Direction not assertedBalancedRhea 18301

N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA

Direction not assertedBalancedRhea 18305

an N-acyl-D-amino acid + H2O = a D-alpha-amino acid + a carboxylate

Direction not assertedBalance undeterminableRhea 18309

(R)-mandelonitrile = benzaldehyde + hydrogen cyanide

Direction not assertedBalancedRhea 18313

an L-alpha-amino acid = a D-alpha-amino acid

Direction not assertedBalance undeterminableRhea 18317

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate

Left to rightBalancedRhea 18321

(2E,6E)-farnesyl diphosphate = (+)-amorpha-4,11-diene + diphosphate

Direction not assertedBalancedRhea 18325

(1S,3R,5S)-sabinol + NAD(+) = (1S,5S)-sabinone + NADH + H(+)

Direction not assertedBalancedRhea 18329

oleandomycin + ATP = oleandomycin 2'-O-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 18333

D-ribose 5-phosphate + uracil = psi-UMP + H2O

Direction not assertedBalancedRhea 18337

D-xylono-1,4-lactone + H2O = D-xylonate + H(+)

Direction not assertedBalancedRhea 18341

a cis-3-alkyl-4-alkyloxetan-2-one = a cis-alkene + CO2

Direction not assertedBalance undeterminableRhea 18345

tRNA(Asx) + L-aspartate + ATP = L-aspartyl-tRNA(Asx) + AMP + diphosphate

Direction not assertedBalancedRhea 18349

2 K(+)(out) + 3 Na(+)(in) + ATP + H2O = 2 K(+)(in) + 3 Na(+)(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 18353

tropine + NADP(+) = tropinone + NADPH + H(+)

Direction not assertedBalancedRhea 18357

a di-trans,poly-cis-dolichyl D-xylosyl phosphate + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)

Direction not assertedBalance undeterminableRhea 18361

(R)-malate + NAD(+) = pyruvate + CO2 + NADH

Direction not assertedBalancedRhea 18365

sn-glycerol 3-phosphate + O2 = dihydroxyacetone phosphate + H2O2

Direction not assertedBalancedRhea 18369

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)

Left to rightBalance undeterminableRhea 18373

streptomycin + ATP = streptomycin 3''-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 18377

dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate

Direction not assertedBalancedRhea 18381

acetone + hydrogencarbonate + 2 ATP + 3 H2O = acetoacetate + 2 AMP + 4 phosphate + 4 H(+)

Direction not assertedBalancedRhea 18385

alpha-D-xylose 1-phosphate + UTP + H(+) = UDP-alpha-D-xylose + diphosphate

Direction not assertedBalancedRhea 18389

(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

Left to rightBalancedRhea 18393

tRNA(Glx) + L-glutamate + ATP = L-glutamyl-tRNA(Glx) + AMP + diphosphate

Left to rightBalancedRhea 18397

(E)-4-hydroxyphenylacetaldehyde oxime + reduced [NADPH--hemoprotein reductase] + O2 = (S)-4-hydroxymandelonitrile + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 18401

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