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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Materials
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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

151–200 of 18,558 reactions from Rhea

D-mannonate + NAD(+) = D-mannuronate + NADH + H(+)
Direction not assertedBalancedRhea 10632
D-mannonate + NADP(+) = D-mannuronate + NADPH + H(+)
Direction not assertedBalancedRhea 10636
2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)
Direction not assertedBalancedRhea 10644
2-hydroxycyclohexan-1-one + NADPH + O2 + H(+) = 6-hydroxyhexan-6-olide + NADP(+) + H2O
Direction not assertedBalancedRhea 10648
a long-chain fatty aldehyde + NAD(+) + H2O = a long-chain fatty acid + NADH + 2 H(+)
Left to rightBalance undeterminableRhea 10652
guanidinoacetate + S-adenosyl-L-methionine = creatine + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 10656
L-seryl-[protein] = D-seryl-[protein]

Direction not assertedBalance undeterminableRhea 10660

perillyl alcohol + NAD(+) = perillyl aldehyde + NADH + H(+)

Direction not assertedBalancedRhea 10664

L-lysyl-tRNA(Lys) + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)

Direction not assertedBalance undeterminableRhea 10668

cyclobutadithymidine in DNA = a thymidine dimer in DNA

Direction not assertedBalance undeterminableRhea 10672

(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O

Direction not assertedBalancedRhea 10676

L-proline = D-proline

Direction not assertedBalancedRhea 10680

O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Left to rightBalance undeterminableRhea 10684

streptomycin 6-phosphate + H2O = streptomycin + phosphate

Direction not assertedBalancedRhea 10688

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = pyrroloquinoline quinone + 2 H2O2 + 2 H2O + H(+)

Direction not assertedBalancedRhea 10692

holo-[mycocerosate synthase] + a long-chain fatty acid + ATP = a long-chain fatty acyl-[mycocerosate synthase] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 10696

limonene 1,2-epoxide + H2O = limonene-1,2-diol

Direction not assertedBalancedRhea 10700

tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate

Left to rightBalancedRhea 10704

alpha-D-glucose 1-phosphate + GTP + H(+) = GDP-D-glucose + diphosphate

Direction not assertedBalancedRhea 10708

L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O

Direction not assertedBalancedRhea 10712

D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate

Direction not assertedBalancedRhea 10716

2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione

Direction not assertedBalancedRhea 10720

GDP-6-deoxy-alpha-D-talose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH + H(+)

Direction not assertedBalancedRhea 10724

GDP-6-deoxy-alpha-D-talose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + NADH + H(+)

Direction not assertedBalancedRhea 10728

firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate

Direction not assertedBalance undeterminableRhea 10732

a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)

ReversibleBalance undeterminableRhea 10736

a secondary alcohol + NAD(+) = a ketone + NADH + H(+)

Direction not assertedBalance undeterminableRhea 10740

(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO2 + NADH

Direction not assertedBalancedRhea 10744

hydrogencarbonate + H(+) = CO2 + H2O

ReversibleBalancedRhea 10748

[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n D-aspartate + n ATP = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n phosphate + n H(+)

Direction not assertedBalance undeterminableRhea 10752

pyruvate + phosphate + ATP = phosphoenolpyruvate + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 10756

citrate = oxaloacetate + acetate

Direction not assertedBalancedRhea 10760

(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucocyanidin + succinate + CO2 + H2O + H(+)

Direction not assertedBalancedRhea 10764

(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucopelargonidin + succinate + CO2 + H2O + H(+)

Direction not assertedBalancedRhea 10768

6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O = D-glucose 6-phosphate + D-glucose

Direction not assertedBalancedRhea 10772

(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + NADPH + H(+)

Direction not assertedBalancedRhea 10776

(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + NADH + H(+)

Right to leftBalancedRhea 10780

N(6)-methyl-L-lysyl(36)-[histone H3] + 2-oxoglutarate + O2 = L-lysyl(36)-[histone H3] + formaldehyde + succinate + CO2

Direction not assertedBalance undeterminableRhea 10784

2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + H(+)

Direction not assertedBalancedRhea 10788

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2

Right to leftBalancedRhea 10792

albendazole + NADPH + O2 + H(+) = albendazole S-oxide + NADP(+) + H2O

Left to rightBalancedRhea 10796

XMP + diphosphate = xanthine + 5-phospho-alpha-D-ribose 1-diphosphate

Direction not assertedBalancedRhea 10800

(S)-allantoin = (R)-allantoin

Direction not assertedBalancedRhea 10804

(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-epoxypropylphosphonate + 2 H2O

Direction not assertedBalancedRhea 10808

N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H2O = N-succinyl-L-glutamate + NADH + 2 H(+)

Direction not assertedBalancedRhea 10812

methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside + H2O = methyl beta-D-galactoside + L-fucose

Direction not assertedBalancedRhea 10816

D-threo-isocitrate = D-erythro-isocitrate

Direction not assertedBalancedRhea 10820

(S)-malate + NADP(+) = oxaloacetate + NADPH + H(+)

Direction not assertedBalancedRhea 10824

anthranilate + ATP + CoA = anthraniloyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 10828

a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)

Direction not assertedBalance undeterminableRhea 10832

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